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Chemical Structure| 301692-76-2 Chemical Structure| 301692-76-2

Structure of Polmacoxib
CAS No.: 301692-76-2

Chemical Structure| 301692-76-2

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Polmacoxib is a dual inhibitor that inhibits COX-2 (IC50 ~ 0.1 μg/ml) and carbonic anhydrase with oral activity. This drug has shown the ability to inhibit colorectal adenoma and tumor growth in mouse models, exhibiting anti-inflammatory and anti-tumor potential, suitable for cancer and inflammatory disease research.

Synonyms: CG100649

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Product Details of Polmacoxib

CAS No. :301692-76-2
Formula : C18H16FNO4S
M.W : 361.39
SMILES Code : O=S(C1=CC=C(C(OC2(C)C)=C(C3=CC=CC(F)=C3)C2=O)C=C1)(N)=O
Synonyms :
CG100649
MDL No. :MFCD22570958
InChI Key :IJWPAFMIFNSIGD-UHFFFAOYSA-N
Pubchem ID :9841854

Safety of Polmacoxib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Isoform Comparison

Biological Activity

Description
Polmacoxib (CG100649) is a pioneering orally active nonsteroidal anti-inflammatory drug (NSAID) with the unique capability of dual inhibition, targeting COX-2 with an IC50 approximately 0.1 μg/ml and carbonic anhydrase[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.84mL

2.77mL

1.38mL

27.67mL

5.53mL

2.77mL

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