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[ CAS No. 30489-47-5 ] {[proInfo.proName]}

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Product Details of [ 30489-47-5 ]

CAS No. :30489-47-5 MDL No. :MFCD11908295
Formula : C8H7BrN2O Boiling Point : -
Linear Structure Formula :- InChI Key :WJSGJIBYPNOLBH-UHFFFAOYSA-N
M.W : 227.06 Pubchem ID :39150028
Synonyms :

Safety of [ 30489-47-5 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:
Hazard Statements:H315-H319 Packing Group:
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Application In Synthesis of [ 30489-47-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 30489-47-5 ]

[ 30489-47-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 30384-96-4 ]
  • [ 30489-47-5 ]
YieldReaction ConditionsOperation in experiment
73% With methanol; sodium tetrahydroborate; water; In dichloromethane; at 20℃; for 2h; To solid NaBH4 (8 mg, 0.227 mmol) was added water (0.1 mL) and then <strong>[30384-96-4]6-bromoimidazo[1,2-a]pyridine-3-carbaldehyde</strong> (100 mg, 0.444 mmol), MeOH (0.7 mL) and DCM (0.7 mL) were added and the reaction mixture was stirred at rt for 2 h. The mixture was concentrated under reduced pressure and the material was triturated with ether and then concentrated under reduced pressure to provide the title compound (74 mg, 73%). 1H NMR (500 MHz, DMSO) delta 8.65 (d, J=1.1 Hz, 1H), 7.57 (d, J=9.1 Hz, 1H), 7.53 (s, 1H), 7.38 (dd, J=9.5, 1.9 Hz, 1H), 5.29 (bs, 1H), 4.80 (s, 2H); MS (ESI) [M+H]+ 227.0/229.0;
0.83 g With methanol; sodium tetrahydroborate; at 0℃; for 4.33333h; [1292j 6-Bromoimidazo[1,2-a]pyridine-3-carbonitrile can be prepared as shown in Scheme39: Stirring solution of 6-bromoimidazo[ 1 ,2-a]pyridine-3-carbaldehyde [see Bioorg. Med. Chem. Let. 15(17). 5837-3844; 2007; Int?l Pat. App. Pub. no, 2011/055320] (1.5g, 6.6 mmol) in MeOH (20 mL) was cooled to 0 C and NaBH4 (0.50 g, 13.2 mmol) was added in portions for a period of 20 mm. Cooling was removed after lh and allowed to stir for 3h. The reaction mixture was quenched with water and concentrated by rotary evaporator to dryness. Subsequently, the solid concentrate was diluted with water and collected on the Buchner funnel by suction filtration. The solid was suction dried to obtain (6-bromoimidazo[1,2-a]pyridin-3-yl)methanol as a pale yellow crystalline solid (0.83 g). ?H NMR (300 MHz, DMSO-d6) oe 8.63 (dd, J= 2.0, 0.9 Hz, 1H), 7.55 (dd, J 9.5, 0.9 Hz, 1H), 7.52 (s, 1H), 7.36 (dd, J 9.5, 2.0 Hz, 1H), 5.27 (t, J= 5.4 Hz, 1H), 4.79 (d, J= 5.3 Hz, 2H). See J. Med. Chem., 54(7), 2455-66 (2011).
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