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Chemical Structure| 310886-98-7 Chemical Structure| 310886-98-7

Structure of 310886-98-7

Chemical Structure| 310886-98-7

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Product Details of [ 310886-98-7 ]

CAS No. :310886-98-7
Formula : C10H8FNO2
M.W : 193.17
SMILES Code : O=C(C1=CN(C)C2=C1C=C(F)C=C2)O
MDL No. :MFCD15523396

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Application In Synthesis of [ 310886-98-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 310886-98-7 ]

[ 310886-98-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 23077-43-2 ]
  • [ 74-88-4 ]
  • [ 310886-98-7 ]
YieldReaction ConditionsOperation in experiment
97% With sodium hydride; General procedure: To a suspension of NaH (1 .1 - 2.0 eq.) in DMF or THF (0.35 - 0.44 M) at 0C was added a solution of the indole (1 .0 eq.) in DMF or THF followed by the halo-alkane (1 .3-20 eq.). The reaction mixture was stirred for several minutes at 0C before warming to room temperature (or heating to 50C or reflux, to facilitate the reaction if required). Upon completion the reaction was quenched by addition of NH4CI and the product extracted into EtOAc (3x) or partitioned between EtOAc and HCI (1 M), shaken, separated and extracted with EtOAc (2x), then washed with NH4CI. The combined extracts were washed with brine, dried over MgSO4 and concentrated in vacuo.
 

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