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CAS No. : | 3160-59-6 | MDL No. : | MFCD00027064 |
Formula : | C14H19NO4 | Boiling Point : | 442.8°C at 760 mmHg |
Linear Structure Formula : | - | InChI Key : | N/A |
M.W : | 265.31 | Pubchem ID : | 2724772 |
Synonyms : |
|
TPSA :Topological Polar Surface Area | - | H-Bond Acceptor Count : | - |
XLogP3 : | - | H-Bond Donor Count : | - |
SP3 : | - | Rotatable Bond Count : | - |
Signal Word: | Warning | Class | N/A |
Precautionary Statements: | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
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Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | To a solution of 42.98 g (0.162 mol) of N-benzyloxycarbonyl-L-isoleucine in 150 mL of ethyl acetate was added 36.73 g (0.178mol) of N,N'-dicyclohexylcarbodiimide at 0 C. After the mixture was stirred for 1 h at 0 C, a solution of 16.22 g (0.081 mol) of 1,12-dodecamethylenediamine in 150 mL of chloroform was added, and this solution was stirred for 2 h at 0 C for a further 2 h at room temperature. The resulting mixture was stirred for 10 h at 40 C and then at 55 C overnight. After removing the formed dicyclohexylurea by hot filtration, the filtrate was cooled to room temperature and the gel formed was suction filtered and dried. The crude product was dissolved in 1.2 L of hot 1-propanol and cooled to room temperature. The gel formed was broken well using a mechanical stirrer and suction filtered. After repeating this purification with 1-propanol, 45.48 g (81%) of the dodecamethylenediamide of N-benzyloxycarbonyl-L-isoleucine was obtained. |
A223186[ 28862-89-7 ]
(2R,3R)-2-(((Benzyloxy)carbonyl)amino)-3-methylpentanoic acid
Reason: Optical isomers