There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
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* Storage: {[proInfo.prStorage]}
CAS No. : | 32175-00-1 | MDL No. : | MFCD06411231 |
Formula : | C8H13NO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | SWSXEZOUBBVKCO-UHFFFAOYSA-N |
M.W : | 139.19 | Pubchem ID : | 11423635 |
Synonyms : |
|
Num. heavy atoms : | 10 |
Num. arom. heavy atoms : | 0 |
Fraction Csp3 : | 0.88 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 40.71 |
TPSA : | 29.43 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.0 cm/s |
Log Po/w (iLOGP) : | 2.39 |
Log Po/w (XLOGP3) : | 3.03 |
Log Po/w (WLOGP) : | 1.9 |
Log Po/w (MLOGP) : | 1.46 |
Log Po/w (SILICOS-IT) : | 2.15 |
Consensus Log Po/w : | 2.19 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.55 |
Solubility : | 0.396 mg/ml ; 0.00285 mol/l |
Class : | Soluble |
Log S (Ali) : | -3.31 |
Solubility : | 0.0676 mg/ml ; 0.000486 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -1.44 |
Solubility : | 5.08 mg/ml ; 0.0365 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 2.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 2.58 |
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P233-P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P322-P330-P332+P313-P337+P313-P340-P361-P362-P363-P403-P403+P233-P405-P501 | UN#: | 2810 |
Hazard Statements: | H301-H311-H315-H319-H335 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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(i) K2CO3, acetone, (ii) /BRN= 2080824/; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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(i) K2CO3, acetone, (ii) /BRN= 2080824/; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide In acetone |
Yield | Reaction Conditions | Operation in experiment |
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In benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In diethyl ether Ambient temperature; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
31% | With pyridine 1.) 90 deg C, 2 h, 2.) RT, overnight; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: diethyl ether / Ambient temperature 2: NaNO2, HCO2H / 0.5 h / 0 - 5 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94.5% | In tert-butyl methyl ether; cyclohexanone; at 30℃; for 10h; | 2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethylbenzenesulfonamide (F) prepared in Example 5 (2.6 g, 1.37 mol )After being mixed with trans-p-methylcyclohexyl isocyanate (G) (2.1 g, 1.64 mol), it was dissolved in a mixture of cyclohexanone (45 ml) and methyl tert-butyl ether (30 ml), and heated to 30°C in a water bath. ,After stirring for 10 hours, the heating was stopped, and the mixture was naturally stirred and cooled to 10° C., poured into water, extracted with dichloromethane (90 ml), concentrated, dissolved in ethanol, and crystallized at 3° C.Dry to give 1-[4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl]-benzenesulfonyl]-3 -(trans-4-methylcyclohexyl)-urea (H) (3.74 g), yield 94.5percent, purity 99.82percent. |
86.3% | Example 4Preparation of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans;-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo- 1 H-pyrrole- 1 - carboxamide (I).In a reaction vessel containing (24.2 L) Acetone, 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide (1.0 Kg) and potassium carbonate (0.46 Kg) was added and refluxed at about 55 to 60 C for 1 hr. trans-4-Methyl- cyclohexyl isocyanate was obtained by method known in art from trans-4-methyl- cyclohexylamine. A solution of trans-4-methyl-cyclohexyl isocyanate (0.515 Kg) in toluene (5 L) was prepared and added to the above reaction mixture. This reaction mixture is refluxed for 12 lirs, then cooled. To this cooled reaction mass charge 27 L of water. The reaction mass was filtered and the pH was adjusted to 5.5 to 6.0 by adding acetic acid at about 20 to 250C. The solid obtained was filtered and washed with water. The 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(/7-?ro-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-lH-pyrrole-l- carboxamide (I) obtained is then dried at 90 to 1000C till constant weight. Yield of the product is 86.3percent. Example 5Purification of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(tr?ro-4-methyl cyclohexyl)amino] carbonyl] amino] sulfonyljphenyl] ethyl] -2-oxo- 1 H-pyrrole- 1 - carboxamide (I)In a reaction vessel containing 6.0 L methanol and 1.0 Kg crude Glimepiride, dry ammonia gas was purged at 20 to 25 C till all Glimepiride dissolves and a clear solution is obtained. This homogeneous mass was then charcoalised, filtered and finally neutralized with Glacial acetic acid to pH 5.5 to 6.0, till the entire product precipitates out. The pure Glimepiride was then filtered and dried at 65C to 700C till constant weight. Yield obtained was ~ 90percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With methyllithium; lithium bromide In diethyl ether at -78℃; for 1h; chemoselective reaction; | Chemoselective Addition of Lithium Carbenoids to Isocyanates; General Procedure 1 (GP1) General procedure: To a cooled (-78°C) solution of isocyanate (1.0 equiv) in dry Et2O (1 M concentration) was added the dihalomethane derivative (1.5 equiv). After 2 min, an ethereal solution of 1.5 M MeLi-LiBr (1.25equiv) was added dropwise over 5 min. The resulting solution was stirred for the appropriate time (see Table 1 and Scheme 2) at that temperature. Sat. aq NH4Cl was added (2 mL/mmol substrate) and the cooling bath was removed, the mixture was stirred till it reached r.t., and then it was extracted with additional Et2O (2 × 5 mL) and washed with water (5 mL) and brine (10 mL). The organic phase was dried (anhyd Na2SO4), filtered, and the solvent removed under reduced pressure to give pure samples of haloacetamides. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With zirconocene dichloride; lithium tri-t-butoxyaluminum hydride In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere; chemoselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 3h; | 12 Example 12 167 g (1.5 mol) of trans-4-methylcyclohexylamine (HTDA) and 500 ml of xylene were charged with a stirrer1.5L stainless steel reactor, filled with 248g (3.75mol) carbonyl fluoride after the closed system, at 50 ° C reaction 3h, the reaction is completedAfter the drop to room temperature, the reactor as a distillation tower kettle, direct distillation, adjust the tower temperature, to ensure that the system pressure for the IMpa, towerThe top temperature is _40 ° C, the top of the tower to produce carbonyl fluoride 139g, the recovery rate of 93.6%, and then the kettle heated to 140 ° (aboutThe pressure of the system is 0.5Mpa, the top temperature is 20 ° C, the top of the column is 26.6g of hydrogen fluoride and the recovery is 88.7%. Then in the oftenPressure, temperature 140 ° C reaction 3h removal of hydrogen fluoride, after the end of the reaction, the top of the refrigerant temperature of 20 ° C, the top of the extraction of hydrogen fluoride25.8g, the recovery rate was 86%. The solvent was recovered by distillation under reduced pressure. 480ml of solvent xylene was used to obtain 193.6g of crude product of trans-4-methylcyclohexylisocyanate (HTDI), purity of 95.0% and product yield of 89.5%. The recovered solvent is returned to the solvent tank. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Add 67 kg of acetonitrile to the 200 L reactor.Intermediate 3 refined product 8.47kg, potassium carbonate 4.00kg,Turn on the agitation and warm to 50-60 ° C.6.01 kg of trans-4-methylcyclohexyl isocyanate was added, and the reaction was continued for 6 hours.Sampling HPLC control, the reaction is complete, filtered, washed,The obtained glimepiride metal salt crude wet product is put into the next step to remove the insoluble matter. Step 5: remove insolubles, acidify, and refine Adding the above-mentioned glimepiride metal salt crude wet product and 10 times by weight of purified water to a 500 L reaction kettle,Stir at 70-75 ° C for 4 hours, heat filter, filter residue to waste treatment station,The filtrate enters the clean room 500L reactor and is cooled to 20-25 °C.Add 15percent hydrochloric acid to adjust pH=1-2, filter, wash,The obtained glimepiride crude wet product is reflowed by refluxing with 5 times by weight of acetone of glimepiride crude wet product.It is then cooled to room temperature, filtered and dried to obtain a finished glimepiride.HPLC purity >99.5percent,The molar yield was 80percent (based on the intermediate 3 refined product). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
46.5 g | Stage #1: 4-(β-acetylaminoethyl)phenylsulfonamide With potassium carbonate In acetone for 6h; Reflux; Stage #2: (1R,4R)-1-isocyanato-4-methylcyclohexane In acetone for 6h; Reflux; | 1.3; 2.3; 3.3 (3) Preparation of impurity J acetyl (chemical name: 4-((((4-transmethylcyclohexylamino)-carbonyl)-amino)-sulfonyl)-N-acetylphenethylamine) In the four-neck flask, add impurity J. benzenesulfonamide 34.98g, anhydrous potassium carbonate 25.96g, and acetone 650ml. Stir, lReaction at reflux for 6 hours. A solution of trans-p-methylcyclohexyl isocyanate in acetone (25.51g / 170ml) was added dropwise. Finish, continueReflux for 6 hours. Cool to room temperature, add 800 ml of purified water, stir for 5 minutes, and filter to remove insoluble materials. The filtrate is stirredAcetic acid was added dropwise to adjust the pH to neutral, and a large amount of solid was precipitated. Filter and wash the filter cake with purified water. The filter cake was dried under reduced pressure at 50 ° C to obtainImpurity J acetyl 46.50g. HPLC content: 99.7%; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
32.37% | In tetrahydrofuran at 90 - 100℃; for 16h; | 20.9 Step 9 A three-necked RBF was charged with a solution of Intermediate (8) (0.250g, 1.04mmol, 1.0eq) in tetrahydrofuran (25mL), and (1R,4R)-1-isocyanato-4-methyl cyclohexane (0.727g, 5.22mmol, 5eq). The reaction mixture was stirred at 90-100°C for 16h. After completion of reaction the mixture was transferred into water and extracted with dichloromethane. Organic layers were combined, washed with brine solution, dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain the crude material. The crude was purified by silica gel column chromatography (2.6% methanol in dichloromethane) to obtain 0.125g of methyl 2-(1-methyl-3-((1r,4r)-4-methylcyclohexyl)ureido)-5-oxo-5H-thieno[3,2-b]pyran-6-carboxylate (9); Yield: 32.37%; MS(ES): m/z 379.44 [M+H]; 1HNMR (DMSO-d6, 400MHZ): 7.996 (s, 1H), 7.775 (s, 1H), 7.102 (s, 1H), 3.696 (s, 3H), 3.449 (m, 1H), 3.201 (s, 3H), 1.881-1.502 (m, 4H), 1.496-1.392 (m, 5H), 0.912-0.882(d, J=8Hz, 3H). |
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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