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[ CAS No. 321848-65-1 ] {[proInfo.proName]}

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Chemical Structure| 321848-65-1
Chemical Structure| 321848-65-1
Structure of 321848-65-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 321848-65-1 ]

CAS No. :321848-65-1 MDL No. :MFCD08234770
Formula : C12H14BrNO Boiling Point : -
Linear Structure Formula :- InChI Key :HVCLJUVMOVVZBS-NSHDSACASA-N
M.W : 268.15 Pubchem ID :57377187
Synonyms :

Safety of [ 321848-65-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 321848-65-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 321848-65-1 ]

[ 321848-65-1 ] Synthesis Path-Downstream   1~14

  • 1
  • [ 4392-24-9 ]
  • [ 321848-65-1 ]
  • [ 716368-91-1 ]
YieldReaction ConditionsOperation in experiment
73% Stage #1: (4R)-2-(2-bromophenyl)-4-isopropyl-4,5-dihydro-1,3-oxazole With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; for 1h; Stage #2: With selenium In tetrahydrofuran; pentane at -78 - 0℃; for 1h; Stage #3: Cinnamyl bromide In tetrahydrofuran; pentane at 0℃; for 1h;
  • 2
  • [ 716368-88-6 ]
  • [ 321848-65-1 ]
YieldReaction ConditionsOperation in experiment
85% Stage #1: 2-bromo-<i>N</i>-(1-hydroxymethyl-2-methyl-propyl)-benzamide With Vilsmeier reagent In pyridine at 20℃; for 2h; Stage #2: With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 3h; Stage #3: With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran Heating; Further stages.;
With thionyl chloride In dichloromethane
  • 3
  • [ 4276-09-9 ]
  • [ 321848-65-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 2: SOCl2 / CH2Cl2
  • 4
  • [ 7154-66-7 ]
  • [ 321848-65-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 2: SOCl2 / CH2Cl2
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 12 h / 0 - 20 °C 2: thionyl chloride / dichloromethane / 4 h / 0 - 64 °C 3: water; sodium hydroxide / methanol / 4 h / Reflux
  • 5
  • [ 321848-65-1 ]
  • [ 104713-12-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: t-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C 1.2: Se / tetrahydrofuran; pentane / 1 h / -78 - 0 °C 1.3: 73 percent / tetrahydrofuran; pentane / 1 h / 0 °C 2.1: 4 Angstroem molecular sieves; TBHP / vanadyl acetylacetonate / CH2Cl2; decane / -50 °C 2.2: Bu3P / CH2Cl2; decane / 0.17 h / -10 °C
  • 6
  • [ 321848-65-1 ]
  • [ 104713-12-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: t-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C 1.2: Se / tetrahydrofuran; pentane / 1 h / -78 - 0 °C 1.3: 73 percent / tetrahydrofuran; pentane / 1 h / 0 °C 2.1: 4 Angstroem molecular sieves; TBHP / vanadyl acetylacetonate / CH2Cl2; decane / -50 °C 2.2: Bu3P / CH2Cl2; decane / 0.17 h / -10 °C
  • 7
  • [ 4276-09-9 ]
  • [ 7154-66-7 ]
  • [ 321848-65-1 ]
YieldReaction ConditionsOperation in experiment
Stage #1: (R)-2-amino-3-methylbutanol; 2-bromobenzoic acid chloride With triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere; Schlenk technique; Stage #2: With methanesulfonyl chloride In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere; Schlenk technique;
  • 8
  • [ 7681-65-4 ]
  • [ 1271-47-2 ]
  • [ 321848-65-1 ]
  • C24H23BrCuFeNO [ No CAS ]
YieldReaction ConditionsOperation in experiment
8% With bis-triphenylphosphine-palladium(II) chloride; triethylamine In tetrahydrofuran at 50℃; for 24h; Inert atmosphere; Schlenk technique;
  • 9
  • ferrocenylethynylcopper [ No CAS ]
  • [ 321848-65-1 ]
  • C24H23BrCuFeNO [ No CAS ]
YieldReaction ConditionsOperation in experiment
56.2% Stage #1: (4R)-2-(2-bromophenyl)-4-isopropyl-4,5-dihydro-1,3-oxazole With bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran for 0.0833333h; Inert atmosphere; Schlenk technique; Stage #2: ferrocenylethynylcopper In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; Schlenk technique;
  • 10
  • mercury dichloride [ No CAS ]
  • [ 321848-65-1 ]
  • C12H14ClHgNO [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% Stage #1: (4R)-2-(2-bromophenyl)-4-isopropyl-4,5-dihydro-1,3-oxazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h; Stage #2: mercury dichloride at -78 - 20℃; for 2h;
  • 11
  • [ 87-62-7 ]
  • [ 321848-65-1 ]
  • [ 1340476-89-2 ]
YieldReaction ConditionsOperation in experiment
62% With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene for 48h; Inert atmosphere; Reflux; 1.2 (2) Preparation of chiral bidentate ligand The chiral o-bromobenzene-oxazoline (0.8 g, 3 mmol) was dissolved in 50 mL of toluene under nitrogen.2,6-Dimethylaniline (436.2 mg, 3.6 mmol), Pd(OAc) 2 (34 mg, 0.15 mmol), rac-BINAP (93 mg, 0.15 mmol),Sodium tert-butoxide (470.4 mg, 4.2 mmol), heated to reflux for 48 h, cooled and filtered.With NaHCO3 solution (2 × 200mL)Wash with water (2 x 100 mL),concentrate,Column chromatographyThe product was purified (573.7 mg, 62.0%).
  • 12
  • [ 88-65-3 ]
  • [ 321848-65-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: thionyl chloride / 12 h / Reflux 2: triethylamine / dichloromethane / 12 h / 0 - 20 °C 3: thionyl chloride / dichloromethane / 4 h / 0 - 64 °C 4: water; sodium hydroxide / methanol / 4 h / Reflux
  • 13
  • (S)-2-bromo-N-(1-hydroxy-3-methylbut-2-yl)benzamide [ No CAS ]
  • [ 321848-65-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: thionyl chloride / dichloromethane / 4 h / 0 - 64 °C 2: water; sodium hydroxide / methanol / 4 h / Reflux
  • 14
  • C12H15BrClNO [ No CAS ]
  • [ 321848-65-1 ]
YieldReaction ConditionsOperation in experiment
72.5% With water; sodium hydroxide In methanol for 4h; Reflux;
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