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Chemical Structure| 32980-71-5
Chemical Structure| 32980-71-5
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Product Details of [ 32980-71-5 ]

CAS No. :32980-71-5 MDL No. :MFCD02093495
Formula : C6Cl4N4 Boiling Point : -
Linear Structure Formula :- InChI Key :QNKFHUMDHRWWES-UHFFFAOYSA-N
M.W : 269.90 Pubchem ID :97007
Synonyms :

Safety of [ 32980-71-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 32980-71-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 32980-71-5 ]
  • Downstream synthetic route of [ 32980-71-5 ]

[ 32980-71-5 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 32980-71-5 ]
  • [ 58-32-2 ]
Reference: [1] Medicinal Chemistry Research, 1996, vol. 6, # 1, p. 61 - 67
[2] Patent: CN108069972, 2018, A,
  • 2
  • [ 110-89-4 ]
  • [ 32980-71-5 ]
  • [ 7139-02-8 ]
YieldReaction ConditionsOperation in experiment
95% With copper(l) iodide; caesium carbonate In nitrobenzene at 180℃; for 16 h; Inert atmosphere the entire chlorine pyrimido [5, 4 - d] pyrimidine (13.1 g, 48.9 mmol), piperidine, CuI (0.28 g, 1.5 mmol), Cs2 CO3 (16.0 g, 48.9 mmol) is put into the 250 in two mouth flask, add 100 ml nitrobenzene as the reaction solvent, under the protection of nitrogen, 180 °C lower reaction 16 h, oil pump by reducing pressure after the reaction of the nitrobenzene solvent, PE:DCM=6:1 to column chromatography, obtaining the solid 17.0 g, yield of 95.0percent, the selectivity 99percent
Reference: [1] Patent: CN106946887, 2017, A, . Location in patent: Paragraph 0035; 0036; 0037
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 20, p. 4905 - 4922
[3] Medicinal Chemistry Research, 1996, vol. 6, # 1, p. 61 - 67
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 16, p. 3906 - 3920
[5] Patent: CN108069972, 2018, A, . Location in patent: Paragraph 0005; 0017
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