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Structure of KH7
CAS No.: 330676-02-3
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
KH7 is a specific inhibitor of soluble adenylyl cyclase (sAC), with an IC50 of 3-10 μM against recombinant sACt protein (human and others) in cells. KH7 is also an inhibitor of cAMP.
Synonyms: KH 7 free
4.5
*For Research Use Only !
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Batch number can be found on the product's label following the word 'Batch'.
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
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CAS No. : | 330676-02-3 |
Formula : | C17H15BrN4O2S |
M.W : | 419.30 |
SMILES Code : | OC(C=CC(Br)=C2)=C2/C=N/NC(C(C)SC1=NC(C=CC=C3)=C3N1)=O |
Synonyms : |
KH 7 free
|
MDL No. : | MFCD01230899 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H301 |
Precautionary Statements: | P301+P310 |
Class: | 6.1 |
UN#: | 2811 |
Packing Group: | Ⅲ |
In Vitro:
Concentration | Treated Time | Description | References |
Islet β-cells | 30 μmol/L | KH7 inhibited glucose-induced [cAMP]pm oscillations | PMC3292328 | |
PBMCs | 10 or 25 μM | 30 minutes | Inhibition of sAC activity, reduction in cAMP levels | PMC3072460 |
PBMCs | 25 μM | 30 minutes | Minimal effect on basal cAMP levels | PMC3072460 |
NHBE cells | 50 μM | To test the inhibitory effect of KH7 on sAC activity | PMC4291545 | |
HEK293T cells | 50 μM | 48 hours | To test the inhibitory effect of KH7 on sAC activity | PMC4291545 |
Primary mouse cholangiocytes | 100 μM | 3 hours | KH7 treatment also prevented NaGCDC-induced apoptosis in primary mouse cholangiocytes. | PMC5111777 |
H69 human cholangiocytes | 50-100 μM | 1 hour | KH7 dose-dependently inhibited BSIA in both control and AE2 knockdown cholangiocytes and at higher concentrations also prevented NaCDC-induced apoptosis altogether. | PMC5111777 |
MIN6 β-cells | 30 μmol/L | KH7 inhibited glucose-induced [cAMP]pm oscillations | PMC3292328 | |
HEK293 cells | 50 μM | KH7 inhibited the pH recovery rate in sAC-overexpressing HEK293 cells | PMC3888009 | |
Cardiac fibers | 5 μM | 30 minutes | KH7, a soluble adenylyl cyclase inhibitor, reduced ADP-stimulated respiratory rates | PMC5187875 |
Nonpigmented ciliary epithelial cells (NPE) | 50 μM | 2 minutes | KH7 significantly reduced the acetazolamide-induced increase in cAMP | PMC3888009 |
MLTC-1 cells | 6.25, 12.5, 50, 100 µM | 1 hour | KH7 dose-dependently inhibited LH-stimulated cAMP accumulation, with 100 µM concentration almost completely abolishing cAMP accumulation | PMC8125623 |
Ciona intestinalis sperm | 10 μM | 3 min | Investigate the effect of KH-7 on sperm motility and trajectory, results showed KH-7 significantly reduced swimming velocity and decreased the diameter of sperm trajectory. | PMC4159788 |
Human endometrial epithelial cell line (ISK) | 10 µM | 24 hours | KH-7, a selective inhibitor of soluble adenylyl cyclase (sAC), was used to investigate the effect of ENaC knockdown or Ca2+ chelation on CFTR upregulation. Results showed that KH-7 completely reversed the CFTR mRNA increase induced by low-degree ENaC knockdown or BAPTA-AM, suggesting the involvement of sAC-driven cAMP production in the regulation of CFTR. | PMC9469783 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Mice | SAC C2KO mice | Perfusion | 25 μM | To test the regulatory effect of KH7 on CBF | PMC4291545 | |
Male DBA/1 J mice | Collagen-induced arthritis (CIA) mouse model | Intraperitoneal injection | 6 mg/kg | Three times a week for 6 weeks | To evaluate the inhibitory effect of KH7-33 mAb on arthritic symptoms. Results showed that KH7-33 mAb significantly ameliorated the arthritis index, squeaking index, and paw volume. | PMC6235220 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00035490 | Arrhythmia | Phase 3 | Completed | - | - |
NCT03127059 | Dysfunctional Breathing in Ast... More >>hma Less << | Not Applicable | Recruiting | November 2020 | Denmark ... More >> Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Silkeborg, Central Denmark Region, Denmark, 8600 Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Bispebjerg, Danish Capital Region, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Allergi og Lungeklinikken Helsingør Recruiting Helsingør, Danish Capital Region, Denmark, 3000 Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Hvidovre, Danish Capital Region, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Aalborg, Region North, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Naestved, Region Zealand, Denmark Contact: Karen H Andreasson, PT MSc +45 24 25 49 26 khad@regionsjaelland.dk Contact: Uffe Bødtger, MD PhD +45 56 51 45 92 ubt@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Roskilde, Region Zealand, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Less << |
NCT03616912 | Systemic Lupus Erythematosus | Phase 3 | Recruiting | February 16, 2021 | - |
NCT03518086 | Ulcerative Colitis | Phase 3 | Recruiting | December 29, 2021 | - |
NCT03524092 | Ulcerative Colitis | Phase 3 | Recruiting | March 22, 2022 | - |
NCT02100696 | Ulcerative Colitis | Phase 3 | Recruiting | December 26, 2020 | - |
NCT02136069 | Ulcerative Colitis | Phase 3 | Recruiting | March 30, 2023 | - |
NCT03383146 | Gastroparesis ... More >> Diabetes Mellitus Less << | Phase 3 | Recruiting | September 28, 2020 | - |
NCT01671007 | - | Active, not recruiting | January 14, 2020 | - | |
NCT02129699 | Lung Cancer Non-small Cell Sta... More >>ge IV Less << | Phase 3 | Active, not recruiting | September 2020 | - |
NCT02674308 | - | Recruiting | June 30, 2022 | - | |
NCT03094715 | Stroke, Acute ... More >> Cerebral Stroke Cerebrovascular Stroke Apoplexy; Brain Less << | Not Applicable | Not yet recruiting | September 30, 2022 | - |
NCT02850172 | Esophageal Cancer | Not Applicable | Recruiting | April 2019 | Taiwan ... More >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 10048 Contact: Yu-Juan Xu +886-2-23123456 ext 88438 yujuanxu@kimo.com Contact: Cheryl Chia-Hui Chen +886-2-33222390 cherylchen@ntu.edu.tw Less << |
NCT02495922 | Multiple Myeloma | Phase 3 | Active, not recruiting | March 2021 | - |
NCT02690831 | Manual Therapies ... More >> Respiratory Muscle Training Exercise Therapy Inspiratory Capacity Asthma Less << | Not Applicable | Completed | - | Spain ... More >> Centro Superior de Estudios Universitarios La Salle Madrid, Spain, 28023 Less << |
NCT00615940 | Metastatic Breast Cancer | Phase 2 | Completed | - | United States, New York ... More >> Montefiore Medical Center Weiler Division Department New York, New York, United States, 10461 United States, Ohio Universitys Hospital Case Medical Center Cleveland, Ohio, United States, 44106 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 Belgium AZ Klina, Oncology Department Brasschaat, Belgium, 2930 Institut Jules Bordet Oncologie Médicale Bruxelles, Belgium, 1000 CHU de Liège, Domaine Universitaire de Sart-Tilman, Oncology Department Liège, Belgium, 4000 Brazil Irmandade de Misericórdia da Santa Casa de Porto Alegre Porto Alegre, Brazil, 9005 Instituto Nacional do Câncer - INCA Rio de Janeiro, Brazil, 20560 Instituto Brasileiro de Controle do Câncer - IBCC São Paulo, Brazil, 03102 Germany Gemeinschaftspraxis Dr. Brudler, Dr. Heinrich, Dr. Bangerter Augsburg, Germany, 86150 Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Uniklinik Köln Cologne, Germany Universitätsklinikum Essen, Innere Klinik und Poliklinik (Tumorforschung) Essen, Germany, 45147 Uniklinik Frankfurt, Zentrum der Frauenheilkunde und Geburtshilfe Frankfurt/Main, Germany, 60590 Universitätsklinikum der Martin-Luther-Universität Halle-Wittenberg, Poliklinik Gynäkologie Halle/Saale, Germany, 06120 Department of Obstetrics and Gynecology, Technical University Munich, Germany, 81675 Bethesda KH Mönchengladbach, Germany, 41061 Israel Davidof Center, Rabin Medical Center, Department of Oncology Petah Tikva, Israel, 49100 Kaplan Medical Center, Department of Oncolocy Rehovot, Israel, 76100 Sheba Medical Center, Department of Oncology Tel Hashomer, Israel, 52621 Assaf Harofeh medical center, Department of Oncology Zerifin, Israel, 70300 Less << |
NCT02596893 | Crohn Disease | Phase 3 | Terminated(Study terminated by... More >> Sponsor following a recommendation from external DMC based on lack of emerging benefit; there were no new emergent safety findings) Less << | - | - |
NCT01667601 | Schizophrenia | Phase 2 Phase 3 | Completed | - | China, Jilin ... More >> Jilin Medical College Jilin, Jilin, China, 0432 Hong Kong KH/LKS Specialty OPD Shatin/Mongkok, NT/Kln, Hong Kong TM Psy Centre Tuen Mun, NT, Hong Kong Taiwan Taipei Medical University Taipei, Xinyi, Taiwan Less << |
NCT02283437 | Schizophrenia Spectrum Disorde... More >>rs Family Caregivers Less << | Not Applicable | Active, not recruiting | December 31, 2018 | Hong Kong ... More >> KH; LKS Specialty OPD Shatin And Mongkok, NT/Kln, Hong Kong Li Ka Shing Specialty OPD Sha Tin, NT, Hong Kong Less << |
NCT01891227 | Breast Cancer | Phase 2 | Completed | - | Austria ... More >> Hämatologie und Onkologie/Interne E, LKH Feldkirch Feldkirch, Austria, A-6807 Universitätsklinik f. Frauenheilkunde und Geburtshilfe, Klin. Abt. f. Gynäkologie Graz, Austria, 8036 Universitätsklinik f. Innere Medizin, Klin.Abt. f. Onkologie Graz, Austria, 8036 Univ.-Klinik f. Frauenheilkunde; Klinische Abt. f. Gynäkologie u. Geburtshilfe Innsbruck, Austria, A-6020 KH Barmh. Schwestern Linz, Innere Medizin I Hämatologie/Onkologie Linz, Austria, A-4010 Kepler Universitätsklinikum, Med Campus III, Klinik f. Interne 3 - Schwerpunkt Hämatologie u. Onkologie Linz, Austria, A-4021 Universitätsklinik für Innere Medizin III Salzburg, Austria, A-5020 Landeskrankenhaus Steyr, Interne Medizin II Steyr, Austria, A-4400 Less << |
NCT01523639 | Colorectal Cancer ... More >> Steatohepatitis Less << | Phase 2 | Terminated(Prematurely due to ... More >>slow recruitment (07/08/2013). Newly defined study end=LPLV=05/11/2013. ABCSG guaranteed completed treatment period for ethical reasons.) Less << | May 2014 | Austria ... More >> Medical University Graz, Oncology Graz, Styria, Austria, 8036 Medical University Innsbruck, Internal Medicine Innsbruck, Tyrol, Austria, 6020 Hospital St. Vinzenz Zams, Tyrol, Austria, 6511 Hospital BHS Ried Ried, Upper Austria, Austria, 4910 KH BHB Vienna Vienna, Austria, 1021 Med. Univ. Vienna, General Hospital Vienna Vienna, Austria, 1090 KH St. Josef KH Vienna, Austria, 1130 Less << |
NCT00688259 | - | Completed | - | - | |
NCT00688259 | Schizophrenia ... More >> Schizoaffective Disorder Less << | Not Applicable | Completed | - | United States, California ... More >> VA Greater Los Angeles Healthcare System, West Los Angeles, CA West Los Angeles, California, United States, 90073 Less << |
NCT02514161 | Manual Therapies ... More >> Respiratory Muscle Training Exercise Therapy Inspiratory Capacity Less << | Not Applicable | Completed | - | Spain ... More >> Centro Superior de Estudios Universitarios La Salle Madrid, Spain, 28023 Less << |
NCT00975533 | Type 2 Diabetes Mellitus | Phase 3 | Unknown | October 2011 | China, Hong Kong ... More >> Prince of Wales Hospital Not yet recruiting Shatin, Hong Kong, China Principal Investigator: Simon KH Wong, MBChB Sub-Investigator: Alice PS Kong, MBChB Sub-Investigator: Ronald CW Ma, MBChB Sub-Investigator: Juliana CN Chan, MBBS Sub-Investigator: Enders KW Ng, MBChB Sub-Investigator: Vannessa WS Ng, MBChB Sub-Investigator: Francis CC Chow, MBBS Sub-Investigator: Wing Yee So, MBChB Sub-Investigator: Winnie CW Chu, MBChB Less << |
NCT02118584 | Ulcerative Colitis | Phase 3 | Recruiting | April 8, 2025 | - |
NCT00365937 | Melanoma | Phase 1 Phase 2 | Terminated(New regulatories of... More >> the peptides by the pharmaceutical company (the seller)) Less << | August 2009 | Belgium ... More >> Cliniques Universitaires Saint-Luc Brussels, Belgium, 1200 Less << |
NCT01014026 | Uterine Cervical Neoplasms ... More >> Uterine Cervical Dysplasia Less << | Phase 3 | Completed | - | France ... More >> IRSA 37 La Riche, France, 37521 IRSA 72 Le Mans, France, 72000 Service d'Orthogénie, CHRU Tours Tours, France, 37000 Service de Gynécologie, CHRU Tours Tours, France, 37000 Association Paul Metadier Tours, France Less << |
NCT03108352 | Branch Retinal Vein Occlusion ... More >> Macular Edema Less << | Phase 3 | Recruiting | December 2020 | China ... More >> Beijing Friendship Hospital, Capital Medical University Recruiting Beijing, China Contact: Yanling WANG Peking University People's Hospital Recruiting Beijing, China Contact: Xiaoxin LI Beijing Tongren Hospital, Capital Medical University Recruiting Peking, China Contact: wenbin WEI Zhongshan Hospital Recruiting Shanghai, China Contact: Fei YUAN Tianjin Medical University Eye Hospital Recruiting Tianjing, China Contact: Xiaorong LI The Eys Hosptial of Wenzhou Medical University Recruiting Wenzhou, China Contact: Xiaoling LIU The Frist Affiliated Hospital of Xi'an Jiaotong University Recruiting Xi'an, China Contact: Li QIN Less << |
NCT01588301 | Cervical Cancer ... More >> Human Papillomavirus Infection Less << | Early Phase 1 | Completed | - | - |
NCT00741637 | Cholera Vibri... More >>o Infections Diarrhea Less << | Phase 2 | Completed | - | Thailand ... More >> Department of Preventive and Social Medicine Siriraj Hospital Bangkok, Thailand, 10700 Less << |
NCT02255084 | Cancer Cervix | Not Applicable | Completed | - | France ... More >> UH Tours Tours, Indre et Loire, France, 37000 Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.38mL 0.48mL 0.24mL |
11.92mL 2.38mL 1.19mL |
23.85mL 4.77mL 2.38mL |
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Dissolving Methods |
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
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