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[ CAS No. 331003-75-9 ] {[proInfo.proName]}

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Chemical Structure| 331003-75-9
Chemical Structure| 331003-75-9
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Product Details of [ 331003-75-9 ]

CAS No. :331003-75-9 MDL No. :N/A
Formula : C12H11NO4S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 265.29 Pubchem ID :-
Synonyms :

Safety of [ 331003-75-9 ]

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Application In Synthesis of [ 331003-75-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 331003-75-9 ]

[ 331003-75-9 ] Synthesis Path-Downstream   1~22

  • 1
  • [ 29310-88-1 ]
  • [ 331003-75-9 ]
  • 5-(3-ethoxy-4-hydroxybenzylidene)-3-(2-oxo-2-(2-oxo-2H-chromen3yl) ethyl) thiazolidine-2,4-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With potassium carbonate; In N,N-dimethyl-formamide;Microwave irradiation; General procedure: A mixture of 5- benzylidene thiazolidine-2,4-dione derivative(2 mM), brominated coumarin (3 mM), potassiumcarbonate (0.5 g) and DMF (5 mL) in a 100 mL round bottomflask was heated in a modified microwave oven (420 W)for appropriate time and reaction was monitored by TLC.After cooling, the reaction mixture was poured into waterand the crude product was filtered out and recrystallizedfrom acetone [38].
  • 2
  • [ 121-32-4 ]
  • [ 2295-31-0 ]
  • [ 331003-75-9 ]
YieldReaction ConditionsOperation in experiment
90% With piperidine; acetic acid; In toluene; at 80.0℃;Dean-Stark; Thiazolidine-2,4-dione 1g (0.008538 mol), 3-Ethoxy-4-hydroxy-benzaldehyde 1.419g, Piperidine 0.422ml, Acetic acid (0.182 ml) and toluene (20 ml) in a dean-stark apparatus at 80 C, After reacting for 12 hours or longer, it was recrystallized to obtain pure 5- (3-Ethoxy-4-hydroxy-benzylidene) -thiazolidine-2,4-dione. Yield: 90%.
69% With piperidine; In ethanol;Reflux; General procedure: Equimolar mixture of substituted benzaldehyde (20 mM)and 2,4-thiazolidinedione (20 mM) with catalytic amount ofpiperidine (1.4 g, 16 mM) and ethanol (150 mL) was refluxedcontinuously for 30-35 hours. The reaction mixturewas poured into water and filtered. On cooling, the productwas precipitated out from ethanol [36]. This step was used tosynthesize a total of ten intermediates (FP1I-FP10I).
With piperidine; acetic acid; In toluene; at 80.0℃; for 18h;Dean-Stark; General procedure: 2,4-Thiazolidinedione 1.0 g (8.54 mmol) and 4-hydroxybenzaldehyde 1.0 g (1.0 equiv; 8.54 mmol) were dissolved in a 100-mL round flask containing 20 mL toluene. Piperidine 0.40 mL (0.5 equiv; 4.27 mmol) and 0.25 mLacetic acid (0.5 equiv; 4.27 mmol) were added slowly tothe reaction mixture and refluxed at 80 C for over 18 hwith dean-stark trap. The resulting solution was concentrated under reduced pressure to remove the solvent. The residual layer was washed with methanol and dried to afford compounds (a-e) as yellow solid. Synthesis ofcompounds a is shown in Scheme 1.
  • 3
  • [ 644-36-0 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(o-tolyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1. 4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl2-(o-tolyl)acetate (39)Compound 39 was obtained by recrystallization fromethanol as a light yellow solid. 1H NMR (DMSO-d6,300 MHz) delta 12.63 (s, 1H), d 7.78 (s, 1H), d 7.33 (m, 2H), d7.24 (s, 1H), d 7.22 (m, 4H), d 4.08 (q, J = 6.96 Hz, 2H), d3.97 (s, 2H), d 2.33 (s, 3H), d 1.27 (t, J = 6.96 Hz, 3H).
  • 4
  • [ 621-36-3 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(m-tolyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 5
  • [ 622-47-9 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(p-tolyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 6
  • [ 2444-36-2 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(2-chlorophenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 7
  • [ 1878-65-5 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(3-chlorophenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 8
  • [ 1878-66-6 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(4-chlorophenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 9
  • [ 6575-24-2 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(2,6-dichlorophenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 10
  • [ 18698-97-0 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(2-bromophenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 11
  • [ 1878-67-7 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(3-bromophenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 12
  • [ 331003-75-9 ]
  • [ 1878-68-8 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(4-bromophenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 13
  • [ 331003-75-9 ]
  • [ 451-82-1 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(2-fluorophenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 14
  • [ 331003-75-9 ]
  • [ 331-25-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(3-fluorophenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 15
  • [ 331003-75-9 ]
  • [ 405-50-5 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(4-fluorophenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 16
  • [ 93-25-4 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(2-methoxyphenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 17
  • [ 1798-09-0 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(3-methoxyphenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 18
  • [ 104-01-8 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(4-methoxyphenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 19
  • [ 93-40-3 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(3,4-dimethoxyphenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 20
  • [ 331003-75-9 ]
  • [ 951-82-6 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(3,4,5-trimethoxyphenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 21
  • [ 4919-33-9 ]
  • [ 331003-75-9 ]
  • 4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 2-(4-ethoxyphenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: o-Tolylacetic acid (0.59 g; 1.0 equiv; 3.77 mmol) and47.0 mg 4-DMAP (10 mol %; 0.38 mmol) were added to a100-mL round flask containing 1 g compound c (3.77 mmol) and stirred in an ice bath for 5 min after the addition of 20 mL methylene chloride. Afterward, 0.80 g DCC (1.0 equiv; 3.77 mmol) was added into the mixture and allowed to react for 3 h at room temperature, until the starting materials (TLC analysis) began to disappear. The resulting DHU was filtered under reduced pressure. The filtrate was extracted using 0.5 M HCl and a saturated solution of NaHCO3 in order. The solvent was removed under reduced pressure after dehydration using anhydrousMgSO4. The purified solid was obtained by recrystallization from ethanol as a light yellow solid. Synthesis of compounds 39-57 is shown in Scheme 1.
  • 22
  • [ 4441-63-8 ]
  • [ 331003-75-9 ]
  • ((Z)-4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl-4-cyclohexylbutanoate) [ No CAS ]
YieldReaction ConditionsOperation in experiment
93.5% With dmap; dicyclohexyl-carbodiimide In dichloromethane for 18h;
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