Alternatived Products of [ 333357-96-3 ]
Product Details of [ 333357-96-3 ]
CAS No. : | 333357-96-3 |
MDL No. : | MFCD00976439 |
Formula : |
C17H17NO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
267.32
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 333357-96-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 333357-96-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 333357-96-3 ]
- 1
-
[ 110-72-5 ]
-
[ 333357-96-3 ]
-
[ 2499959-54-3 ]
Yield | Reaction Conditions | Operation in experiment |
60% |
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 8h; |
3.2.3. General Procedure for the Synthesis of 1-30
General procedure: The intermediates B (0.374 mmol, 1 equiv.) were dissolved in 5 mL DMF in a vial.2-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (HATU) (156.4 mg,0.411 mmol, 1.1 equiv.) were added to the reaction mixture. A series of corresponding amines orothers ((4-fluorophenyl)hydrazine, 2-bromophenol and 2-bromobenzenethiol) (0.374 mmol, 1 equiv.)and DIPEA (193.3 mg, 1.496 mmol, 4 equiv.) were made in a separate vial. This solution was added tothe reaction mixture drop wise and the reaction mixture was stirred overnight at room temperature.Upon completion of the reaction as detected by TLC, water (10 mL) was added and the productwas extracted with EtOAc (3 x 10 mL). The combined organic layers were dried using MgSO4,then concentrated under vacuum, and the residues were purified by flash chromatography usingPE:EtOAc = 2:1 as an eluent to give the target compounds 1-30. |
Reference:
[1]Jiang, Cheng-Shi; Ge, Yong-Xi; Cheng, Zhi-Qiang; Wang, Yin-Yin; Tao, Hong-Rui; Zhu, Kongkai; Zhang, Hua
[Molecules, 2019, vol. 24, # 14]