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CAS No. : | 340771-31-5 | MDL No. : | MFCD08703578 |
Formula : | C9H8O2S | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LFIDRFMWWROMOU-UHFFFAOYSA-N |
M.W : | 180.22 | Pubchem ID : | 22042612 |
Synonyms : |
|
Num. heavy atoms : | 12 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.11 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 47.47 |
TPSA : | 42.52 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.4 cm/s |
Log Po/w (iLOGP) : | 1.7 |
Log Po/w (XLOGP3) : | 1.41 |
Log Po/w (WLOGP) : | 2.23 |
Log Po/w (MLOGP) : | 2.08 |
Log Po/w (SILICOS-IT) : | 1.74 |
Consensus Log Po/w : | 1.83 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.15 |
Solubility : | 1.28 mg/ml ; 0.00708 mol/l |
Class : | Soluble |
Log S (Ali) : | -1.91 |
Solubility : | 2.23 mg/ml ; 0.0124 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -2.79 |
Solubility : | 0.292 mg/ml ; 0.00162 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.91 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With tetrabutyl ammonium fluoride In tetrahydrofuran for 0.0833333 h; | To a solution of (4-methanesulfonyl-phenylethynyl)-thmethyl-silane (20.7 g , 82.0 mmol) in tetrahydrofuran (450 ml_) was added tetrabutylammonium fluoride hydrate (8.80 g, 27.3 mmol). An immediate color change from yellow to red was observed. After 5 minutes, the reaction was complete, and the solvent was removed in vacuo. Water was added, and the resulting mixture was then extracted three times with ethyl acetate. The combined organic layers were washed with water and brine, dried over magnesium sulfate, filtered, and concentrated. The residue was suspended in dichloromethane, and the insoluble material was filtered off. The filtrate was concentrated to give the crude product. Flash chromatography (RediSep.(R). Flash column, 230-400 mesh, 0-25percent ethyl acetate in hexane) afforded 1-ethynyl-4- methanesulfonyl-benzene (10.7 g, 72percent yield) as a yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.0833333h; | To a solution of (4-methanesulfonyl-phenylethynyl)-thmethyl-silane (20.7 g , 82.0 mmol) in tetrahydrofuran (450 ml_) was added tetrabutylammonium fluoride hydrate (8.80 g, 27.3 mmol). An immediate color change from yellow to red was observed. After 5 minutes, the reaction was complete, and the solvent was removed in vacuo. Water was added, and the resulting mixture was then extracted three times with ethyl acetate. The combined organic layers were washed with water and brine, dried over magnesium sulfate, filtered, and concentrated. The residue was suspended in dichloromethane, and the insoluble material was filtered off. The filtrate was concentrated to give the crude product. Flash chromatography (RediSep Flash column, 230-400 mesh, 0-25% ethyl acetate in hexane) afforded 1-ethynyl-4- methanesulfonyl-benzene (10.7 g, 72% yield) as a yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In tetrahydrofuran; methanol; at 20℃; for 2h; | General procedure: THF / methanol mixed solution (10 mL, 15.0 mL) of the compound of Reference Example 48 (584 mg) in was added potassium carbonate (843 mg), and stirred at room temperature for 2 hours. After completion of the reaction, and extracted with ethyl acetate by the addition of water. The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, vacuum filtered and concentrated, the resulting residue was purified by silica gel column chromatography (n- hexane / ethyl acetate) to give the title compound (324 mg) was obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In triethylamine; N,N-dimethyl-formamide; at 120℃; for 1h;Irradiation; | [4-(3-Bromo-5-cyclohexylmethoxy-phenylsulfanyl)-2-methyl-phenoxy] -acetic acid ethyl acetate (0.1 g; 0.203 mmol), 1 -Ethynyl-4-methanesulfonyl-benzene (0.109 g; 0.61 mmol), bis(triphenylphosphine)palladium (II) chloride (11.4 mg; 0.016 mmol) and copper iodide (2.3 mg; 0.06 mmol) were dissolved in a mixture of triethylamine (2 mL) and DMF (2 mL) under an atmosphere of nitrogen. The reaction mixture was reacted in a microwave oven at 120C for Ih. Water and dichloromethane was added to the reaction mixture and the phases were separated and washed with water. The organic phase was dried and evaporated to dryness. The crude product was purified by prep. HPLC (Metode A). Yield: 90 mg. HPLC- MS: m/z: 593.5 (M+H)+; Rt: 3.04 min. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In triethylamine; N,N-dimethyl-formamide; at 120℃; for 1h;Irradiation; | [4-(3-Bromo-5-cyclopentylmethoxy-phenylsulfanyl)-2-methyl-phenoxy]-acetic acid ethyl acetate (0.24 g; 0.50 mmol), 1 -Ethynyl-4-methanesulfonyl-benzene (0.271 g; 1.5 mmol), bis(triphenylphosphine)palladium (II) chloride (28.11 mg; 0.04 mmol) and copper iodide (5.7 mg; 0.03 mmol) were dissolved in a mixture of triethylamine (5 mL) and DMF (5 mL) under an atmosphere of nitrogen. The reaction mixture was reacted in a microwave oven at 120C for Ih. Water and dichloromethane was added to the reaction mixture and the phases were separated and washed with water. The organic phase was dried and evaporated to dryness. The crude product was purified by prep. HPLC (Metode A). Yield: 180 mg. HPLC-MS: m/z: 579.4 (M+H)+; Rt: 3.00 min. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
34% | With copper(l) iodide; triethylamine;bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 65℃; for 1h;Microwave irradiation; | Example 10; (4-{3-[3-(4-Methanesulfonyl-phenylethynyl)-5-(3-morpholin-4-yl-prop-1-ynyl)-phenyl]-prop-2- ynyloxy}-2-methyl-phenoxy)-acetic acidA mixture of 1-ethynyl-4-methanesulfonyl-benzene (346 mg, 1.92 mmol), (4-{3-[3- bromo-5-(3-morpholin-4-yl-prop-1-ynyl)-phenyl]-prop-2-ynyloxy}-2-methyl-phenoxy)-acetic acid methyl ester (123 mg, 0.24 mmol, example 6), Pd(PPh3)2CI2 (17 mg, 0.024 mmol), CuI (12 mg, 0.067 mmol) in dry DMF (2 ml) and triethylamine (2 ml) was heated in a microwave own for 1 hour at 65 0C in a sealed tube. The reaction mixture was filtered through Decalite and the filtrate was evaporated. The residue was purified on column chromatography using methylene chloride/THF mixtures to give (4-{3-[3-(4-methanesulfonyl-phenylethynyl)-5-(3- morpholin-4-yl-prop-1 -ynyl)-phenyl]-prop-2-ynyloxy}-2-methyl-phenoxy)-acetic acid methyl ester in 50 mg (34%) yield. 1H NMR (CDCI3): delta 2.29 (3H, s), 2.65 (4H, t), 3.08 (3H,s), 3.52 (2H, s), 3.77 (4H, t), 3.79 (3H, s), 4.62 (2H, s), 4.84 (2H, s), 6.65-7.00 (3H, m), 7.43-7.97 (7H, m). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79% | With triethylamine;bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; at 20 - 80℃; | A degassed mixture of i -ethynyl-4-methanesulfonyl-benzene (2.5 g, 13.87 mmol), bis(triphenylphosphine)palladium(ll) chloride (0.49 g, 0.69 mmol), copper(l) iodide (0.13 g, 0.69 mmol), triethylamine (28 ml_), and 2-bromo-4-fluorobenzaldehyde (3.38 g, 16 mmol) in dichloromethane (10 ml_) was stirred at 80 C for 3.5 hours, then at room temperature overnight. The reaction mixture was partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo. Flash chromatography (RediSep Flash column, 230-400 mesh, 15-35% ethyl acetate in hexane) gave 4-fluoro-2-(4-methanesulfonyl- phenylethynyl)-benzaldehyde (3.32 g, 79%). MS (ESI+) cald. for CI6HH FO3S [(M+H)+] 302, obsd. 302. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
21% | With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In toluene; at 100℃; for 18h;Inert atmosphere; | General procedure: RuAAC. A mixture of azide 2-6 (0.02 M) and alkyne 1 (11.5 equiv.) in toluene with [Cp*RuCl(cod)] (5 mol%) was heated (100 C) with stirring overnight (18 hours). The reaction mixture was evaporated in vacuo then purified by flash chromatography (gradient 1:1 ethyl acetate: nhexanes to 100 % ethyl acetate). A solid was obtained, with yields calculated following sample drying under high vacuum. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56% | With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In toluene; at 100℃; for 18h;Inert atmosphere; | General procedure: RuAAC. A mixture of azide 2-6 (0.02 M) and alkyne 1 (11.5 equiv.) in toluene with [Cp*RuCl(cod)] (5 mol%) was heated (100 C) with stirring overnight (18 hours). The reaction mixture was evaporated in vacuo then purified by flash chromatography (gradient 1:1 ethyl acetate: nhexanes to 100 % ethyl acetate). A solid was obtained, with yields calculated following sample drying under high vacuum. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In toluene; at 100℃; for 18h;Inert atmosphere; | General procedure: RuAAC. A mixture of azide 2-6 (0.02 M) and alkyne 1 (11.5 equiv.) in toluene with [Cp*RuCl(cod)] (5 mol%) was heated (100 C) with stirring overnight (18 hours). The reaction mixture was evaporated in vacuo then purified by flash chromatography (gradient 1:1 ethyl acetate: nhexanes to 100 % ethyl acetate). A solid was obtained, with yields calculated following sample drying under high vacuum. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
43% | With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In toluene; at 100℃; for 18h;Inert atmosphere; | General procedure: RuAAC. A mixture of azide 2-6 (0.02 M) and alkyne 1 (11.5 equiv.) in toluene with [Cp*RuCl(cod)] (5 mol%) was heated (100 C) with stirring overnight (18 hours). The reaction mixture was evaporated in vacuo then purified by flash chromatography (gradient 1:1 ethyl acetate: nhexanes to 100 % ethyl acetate). A solid was obtained, with yields calculated following sample drying under high vacuum. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
27% | With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In toluene; at 100℃; for 18h;Inert atmosphere; | General procedure: RuAAC. A mixture of azide 2-6 (0.02 M) and alkyne 1 (11.5 equiv.) in toluene with [Cp*RuCl(cod)] (5 mol%) was heated (100 C) with stirring overnight (18 hours). The reaction mixture was evaporated in vacuo then purified by flash chromatography (gradient 1:1 ethyl acetate: nhexanes to 100 % ethyl acetate). A solid was obtained, with yields calculated following sample drying under high vacuum. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
at 95 - 100℃; for 4h;Inert atmosphere; | General procedure: A mixture of amino pyridine 1 (1.0 mmol), 10%Pd/C (0.010 mmol), CuI (0.010 mmol), PPh3 (0.022 mmol) and Cs2CO3 (3 mmol) in PEG-400 (3 mL) was stirred for 15 min at room temperature under a nitrogen atmosphere. To this was added an appropriate iodoarene 2 (1.0 mmol) and the mixture was stirred further for 10 min. The mixture was then stirred at 95 - 100 C for 2.5 h under ultrasound irradiation using a laboratory ultrasonic bath Sonorex Super RK 510H model producing irradiation of 35 kHz. After cooling the mixture to room temperature an appropriate terminal alkyne 3 (1.2 mmol) was added to it. The mixture was then stirred again at 95-100 C for 4h under ultrasound irradiation. After completion of the reaction (indicated by TLC), the mixture was diluted with cold water (30 mL) and extracted with CH2Cl2 (3 x 10 mL). The organic layers were collected, combined, washed with cold water (2 x 15 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was then purified by column chromatography on silica gel using EtOAc / n-hexane as a solvent system. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In 1,4-dioxane; at 110℃; | General procedure: Ketone 2a (50.2 mg, 0.25 mmol, 1.0 equiv.) andp-toluensulfonyl hydrazide (56.1 mg, 0.30 mmol, 1.2 equiv.) were dissolved in MeOH (4 mL). A drop ofHCl was added to the mixture, which was then refluxed for 3 h. Then, the mixture was cooled to rt andthe solvent was evaporated in vacuo. To this mixture, the terminal alkyne 3a (60.3 mg, 0.50 mmol, 2.0equiv.) and K2CO3 (69.4 mg, 0.50 mmol, 2.0 equiv.) were added and the mixture was dissolved indioxane (4 mL). The system was heated at 110 C for 12 h. The crude reaction was cooled down to rt, thesolvent was eliminated in vacuo and a NaHCO3 sat. aq. sol. and AcOEt were added. The layers wereseparated. The aqueous phase was extracted three times with AcOEt. The combined organic layers werewashed with NaHCO3 sat. aq. sol., brine, dried over Na2SO4 and filtered. Solvent was removed underreduced pressure. Finally product was purified by flash column chromatography on silica gel(Petrolether:AcOEt 2:8). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In 1,4-dioxane; at 110℃; | General procedure: Ketone 2a (50.2 mg, 0.25 mmol, 1.0 equiv.) andp-toluensulfonyl hydrazide (56.1 mg, 0.30 mmol, 1.2 equiv.) were dissolved in MeOH (4 mL). A drop ofHCl was added to the mixture, which was then refluxed for 3 h. Then, the mixture was cooled to rt andthe solvent was evaporated in vacuo. To this mixture, the terminal alkyne 3a (60.3 mg, 0.50 mmol, 2.0equiv.) and K2CO3 (69.4 mg, 0.50 mmol, 2.0 equiv.) were added and the mixture was dissolved indioxane (4 mL). The system was heated at 110 C for 12 h. The crude reaction was cooled down to rt, thesolvent was eliminated in vacuo and a NaHCO3 sat. aq. sol. and AcOEt were added. The layers wereseparated. The aqueous phase was extracted three times with AcOEt. The combined organic layers werewashed with NaHCO3 sat. aq. sol., brine, dried over Na2SO4 and filtered. Solvent was removed underreduced pressure. Finally product was purified by flash column chromatography on silica gel(Petrolether:AcOEt 2:8). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In 1,4-dioxane; at 110℃; | General procedure: Ketone 2a (50.2 mg, 0.25 mmol, 1.0 equiv.) andp-toluensulfonyl hydrazide (56.1 mg, 0.30 mmol, 1.2 equiv.) were dissolved in MeOH (4 mL). A drop ofHCl was added to the mixture, which was then refluxed for 3 h. Then, the mixture was cooled to rt andthe solvent was evaporated in vacuo. To this mixture, the terminal alkyne 3a (60.3 mg, 0.50 mmol, 2.0equiv.) and K2CO3 (69.4 mg, 0.50 mmol, 2.0 equiv.) were added and the mixture was dissolved indioxane (4 mL). The system was heated at 110 C for 12 h. The crude reaction was cooled down to rt, thesolvent was eliminated in vacuo and a NaHCO3 sat. aq. sol. and AcOEt were added. The layers wereseparated. The aqueous phase was extracted three times with AcOEt. The combined organic layers werewashed with NaHCO3 sat. aq. sol., brine, dried over Na2SO4 and filtered. Solvent was removed underreduced pressure. Finally product was purified by flash column chromatography on silica gel(Petrolether:AcOEt 2:8). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In 1,4-dioxane; at 110℃; | General procedure: Ketone 2a (50.2 mg, 0.25 mmol, 1.0 equiv.) andp-toluensulfonyl hydrazide (56.1 mg, 0.30 mmol, 1.2 equiv.) were dissolved in MeOH (4 mL). A drop ofHCl was added to the mixture, which was then refluxed for 3 h. Then, the mixture was cooled to rt andthe solvent was evaporated in vacuo. To this mixture, the terminal alkyne 3a (60.3 mg, 0.50 mmol, 2.0equiv.) and K2CO3 (69.4 mg, 0.50 mmol, 2.0 equiv.) were added and the mixture was dissolved indioxane (4 mL). The system was heated at 110 C for 12 h. The crude reaction was cooled down to rt, thesolvent was eliminated in vacuo and a NaHCO3 sat. aq. sol. and AcOEt were added. The layers wereseparated. The aqueous phase was extracted three times with AcOEt. The combined organic layers werewashed with NaHCO3 sat. aq. sol., brine, dried over Na2SO4 and filtered. Solvent was removed underreduced pressure. Finally product was purified by flash column chromatography on silica gel(Petrolether:AcOEt 2:8). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | General procedure: To a stirred solution of the proper methyl 2-haloarylcarboxylate (3a or 9a) (0.5mmol) in anhydrous DMF (2mL), K2CO3 (2.5mmol), the appropriate alkyne (0.6mmol, 1.2 equiv) and (PPh3)2PdCl2 (2mol%) were added under nitrogen. The reaction was stirred at rt for 10min, then CuI (1mol%) was added. The reaction mixture was stirred at 60C until no more starting product was detected by TLC analysis. The reaction mixture was diluted with water (50mL) and extracted with EtOAc (3×15mL). The organic layers were united, dried over Na2SO4 and the solvent was evaporated under reduced pressure. The crude material was purified by flash column chromatography over silica gel. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
66% | General procedure: Under a nitrogen atmosphere, methyl 2-bromo-5-methoxybenzoate 3b (0.408mmol) was dissolved in 0.5mL of anhydrous TEA and 1.5mL of anhydrous CH3CN. To the stirred mixture the appropriate alkyne (0.489mmol, 1.2 eq.), bis(acetonitrile)dichloropalladium(II) (14mol%) and tri-tert-butylphosphine (20mol %) were added. The reaction was stirred at rt for 15min, then CuI (5mol%) was added. The stirred reaction was heated at 70C until no more starting product was detected by TLC analysis, then filtered on a thin Celite pad. The pad was washed with CH2Cl2, and then the united organic layers were evaporated under reduced pressure. The crude material was purified by flash chromatography over silica gel to yield the desired products. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With trimethylsilylazide; water; silver carbonate; In dimethyl sulfoxide; at 80℃; | General procedure: To a solution of substrate (5 mmol), TMSN3 (0.98 ml, 7.5 mmol) and H2O (0.18 mL, 10 mmol) inDMSO (5 mL) at 80 oC was added Ag2CO3 (138 mg, 0.5 mmol). Then the mixture was stirred until (1-2 h)the complete consumption of substrate as indicated by TLC. The resulting mixture was concentrated andtaken up by dichloromethane (3 × 30 mL). The organic layer was washed with brine (3 × 40 mL), driedover MgSO4 and concentrated. The resulting crude materials were purified by flash columnchromatography (silica gel; hexane) to afford vinyl azides. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; [Cu(2,9-di-i-propyl-4,7-diphenyl-1,10-phenanthroline)(xantphos)]PF6; diethylamine; In acetonitrile; for 12h;Schlenk technique; Inert atmosphere; Microwave irradiation; | Add the photosensitizer PS5 (0.005 mmol, 6.0 mg), 4-methylsulfophenylacetylene (0.2 mmol, 32 mg), and Hans ester (0.24 mmol, 60.8 mg) to a dry Schlenk reaction tube, and replace with nitrogen three times. Add a solution of butyraldehyde (1.0 mmol, 72.1 mg) and diethylamine (1.0 mmol, 73.1 mg) in acetonitrile (4 mL) under nitrogen protection, and place the reaction tube under a 15W blue LED for 12 hours and stir. After the reaction, 100-200 mesh silica gel was added to the obtained reaction solution, and the solvent was distilled off under reduced pressure. The obtained crude product was separated by silica gel column chromatography, and petroleum ether / ethyl acetate = 5/1 was used as washing. The solvent was removed for elution, TLC followed the elution process, collected the eluate containing the target product, and combined the eluents to evaporate the solvent to obtain the pure product. This material was a colorless liquid with a yield of 13% and E / Z of the product = 10/1. |
Tags: 340771-31-5 synthesis path| 340771-31-5 SDS| 340771-31-5 COA| 340771-31-5 purity| 340771-31-5 application| 340771-31-5 NMR| 340771-31-5 COA| 340771-31-5 structure
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P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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