Structure of D-Mannose
CAS No.: 3458-28-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
D-Mannose, a carbohydrate, can participate in glycosylation of proteins and metabolism of the body.
Synonyms: Carubinose; NSC 26247; (+)-Mannose
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 3458-28-4 |
Formula : | C6H12O6 |
M.W : | 180.16 |
SMILES Code : | O=C[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O |
Synonyms : |
Carubinose; NSC 26247; (+)-Mannose
|
MDL No. : | MFCD00799233 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
In Vitro:
Concentration | Treated Time | Description | References |
RAW264.7 cells | 25 mM | Inhibited osteoclast proliferation and fusion | PMC9827691 | |
Rat bone marrow monocytes (rBMMs) | 25 mM | 4 days | Suppressed osteoclast proliferation and bone resorption capacity | PMC9827691 |
Human macrophages derived from peripheral blood monocytes | 11 mM | 24 h | Inhibited IL-1β production | PMC7733482 |
RAW 264.7 murine macrophage cell line | 11 mM | 24 h | Inhibited pro-inflammatory cytokine IL-1β production | PMC7733482 |
Rat kidney epithelial NRK-52E cells | 20 mM | 2 h | To investigate the inhibitory effect of D-Mannose on cisplatin-induced GSDME-dependent pyroptosis. Results showed that D-Mannose substantially suppressed cisplatin-induced pyroptotic morphology, GSDME cleavage, and LDH release. | PMC10709431 |
Human normal intestinal FHs 74 Int cells | 20 mM | 2 h | To investigate the inhibitory effect of D-Mannose on cisplatin-induced GSDME-dependent pyroptosis. Results showed that D-Mannose substantially suppressed cisplatin-induced pyroptotic morphology, GSDME cleavage, and LDH release. | PMC10709431 |
Human breast cancer MDA-MB-468 cells | 20 mM | 2 h | To investigate the inhibitory effect of D-Mannose on raptinal-induced GSDME-dependent pyroptosis. Results showed that in GSDME-overexpressing MDA-MB-468 cells, raptinal-induced pyroptosis was clearly inhibited by mannose. | PMC10709431 |
Human lung adenocarcinoma PC-9 cells | 20 mM | 2 h | To investigate the inhibitory effect of D-Mannose on raptinal-induced GSDME-dependent pyroptosis. Results showed that in GSDME-overexpressing PC-9 cells, raptinal-induced pyroptosis was clearly inhibited by mannose. | PMC10709431 |
Melanoma A375 cells | 20 mM | 2 h | To investigate the inhibitory effect of D-Mannose on CCCP/FeSO4-induced GSDME-dependent pyroptosis. Results showed that D-Mannose dramatically reversed CCCP/iron-induced pyroptosis, including pyroptotic morphology, GSDME cleavage, and lactate dehydrogenase (LDH) release. | PMC10709431 |
peritoneal macrophages | 20 mM | 12 h | To assess the effect of mannose on TNF-α production in macrophages. Results showed that mannose significantly suppressed LPS-induced TNF-α production, and this effect was achieved by reducing GAPDH binding to TNF-α mRNA. | PMC9887054 |
colon organoids | 10 mM | 24 h | To investigate the effect of mannose on inflammation-induced damage in colon organoids. Results showed that mannose significantly rescued the viability of organoids and reduced the expression of ERS markers. | PMC9887054 |
intestinal epithelial cells (IECs) | 10 mM | 24 h | To evaluate the effect of mannose on inflammation-induced endoplasmic reticulum stress (ERS). Results showed that mannose significantly reduced the expression of GRP78 and CHOP, indicating its ability to alleviate inflammation-induced ERS. | PMC9887054 |
Mouse bone marrow-derived macrophages (BMDMs) | 11 mM | 24 h | Inhibited LPS-induced Il1b gene expression and IL-1β secretion | PMC7733482 |
bone marrow-derived monocytes | 0 mM, 1 mM, 10 mM, 50 mM | 4 h | To assess the effect of D-mannose on macrophage phagocytic capability. It was found that as D-mannose concentration increased, the phagocytic capability of M1 and M2 macrophages significantly decreased. | PMC8673064 |
Lymphoma YAC-1 cells | 50 mM | 4 h | All tested sugars (including D-mannose) blocked NK cell-mediated cytotoxicity (CMC) against YAC-1 target cells | PMC349512 |
Fibrosarcoma MethA cells | 50 mM | 24 h | D-Mannose significantly blocked NC cell-mediated cytotoxicity (CMC) against MethA target cells | PMC349512 |
HaCaT cells | 5 mM | 24-48 h | D-Mannose inhibited AGEs generation and protected the physiological functions of keratinocytes under high glucose conditions. | PMC11748336 |
NHEK cells | 5 mM | 24-48 h | D-Mannose inhibited AGEs generation and protected the physiological functions of keratinocytes under high glucose conditions. | PMC11748336 |
Primary mouse chondrocytes | 25 mM | 24 and 48 h | To evaluate the protective effect of D-mannose on IL-1β-induced chondrocyte ferroptosis. Results showed that D-mannose significantly attenuated IL-1β-induced chondrocyte ferroptosis by inhibiting lipid peroxidation and upregulating the expression of GPX4 and SLC7A11. | PMC8560605 |
gdT cells | 50 mM | 72 h | To evaluate the impact of D-mannose on gdT cells, results showed that D-mannose treatment reduced the proliferation and glycolytic capabilities of gdT cells. | PMC8918796 |
Primary mouse hepatocytes (PMHs) | 5 mM | 24 h | To evaluate the effect of D-mannose on ethanol-induced lipid accumulation in hepatocytes. Results showed that D-mannose significantly reduced ethanol-induced elevation of intracellular TG and TC levels and confirmed reduced lipid droplet accumulation via BODIPY staining. | PMC9021718 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
C57BL/6 mice | Cisplatin-induced small intestine and kidney toxicity model | Oral gavage | 20% (w/v), 500 μL/day | Once daily for 5 days | To investigate the protective effect of D-Mannose on cisplatin-induced small intestine and kidney toxicity. Results showed that D-Mannose effectively protected the small intestine and kidney from cisplatin-induced damage by activating AMPK and suppressing GSDME cleavage. | PMC10709431 |
Mice | DSS-induced colitis model | Oral | 15% , dissolved in drinking water | Continuous administration for 8 days | To evaluate the effect of mannose on colitis development. Results showed that mannose significantly ameliorated DSS-induced colitis symptoms, including body weight loss, colon shortening, and histological damage. | PMC9887054 |
Mice (Balb/c) | LPS-induced endotoxemia model | Intraperitoneal injection | 2 g/kg | Hourly, up to six times | Reduced serum IL-1β levels and improved survival rate | PMC7733482 |
Mice | Experimental autoimmune encephalomyelitis (EAE) | Intraperitoneal injection | 450 mg/kg | Once daily from the day of induction until day 19 | To evaluate the effect of D-mannose on EAE symptoms. D-mannose treatment improved EAE symptoms, reduced MPO-mediated oxidative stress, and partially blocked macrophage/microglia phagocytosis. | PMC8673064 |
Rats | Tail-suspended rat model | Intragastric administration | 1.1 M | Once daily for 28 days | Prevented bone loss and urinary tract infections under weightlessness | PMC9827691 |
Balb/c mice | STZ-induced diabetic mice model | Topical application on skin | 3% (w/v) | Once daily for 13 days | D-Mannose significantly improved skin wound healing in diabetic mice, inhibited AGEs generation, and activated the AMPK/Nrf2/HO-1 signaling pathway. | PMC11748336 |
C57BL/6J mice | ACLT-induced osteoarthritis model | Oral drinking water | 20%, in drinking water | Administration started two weeks before surgery and continued until 4 and 8 weeks post-surgery | To evaluate the effect of D-mannose on ACLT-induced osteoarthritis progression. Results showed that D-mannose significantly alleviated cartilage degeneration, reduced OARSI scores, and inhibited HIF-2α-mediated chondrocyte ferroptosis. | PMC8560605 |
C57BL/6 mice | IMQ-induced psoriasis model | Oral | 20% (w/v), 200mL | Twice daily for one week | To evaluate the impact of D-mannose on IMQ-induced psoriasis, results showed that D-mannose treatment significantly alleviated skin inflammation. | PMC8918796 |
C57BL/6 mice | Chronic-binge ethanol feeding ALD mouse model | Drinking-water supplementation | 1%, 2%, 3% (w/v) | 11 days | To evaluate the effect of D-mannose on hepatic steatosis in ALD mice. Results showed that D-mannose significantly alleviated ethanol-induced hepatic steatosis, reduced serum ALT and AST levels, decreased hepatic TG and TC contents, and confirmed reduced hepatic lipid deposition via H&E and Oil Red O staining. | PMC9021718 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02180906 | - | Completed | - | Denmark ... More >> Copenhagen University Hospital, Rigshospitalet Copenhagen, Denmark, 2100 Less << | |
NCT03267407 | - | Active, not recruiting | March 31, 2018 | Vietnam ... More >> National Hospital for Tropical Diseases Hanoi, Vietnam, 100000 Less << | |
NCT00717730 | Diarrhea Pneu... More >>monia Less << | Phase 2 | Completed | - | India ... More >> Society for Essential Health Action and Training New Delhi, Delhi, India Less << |
NCT01833312 | Acute Ischemic Stroke | Phase 3 | Recruiting | December 2020 | Germany ... More >> Department of Neurology, University Hospital Erlangen Recruiting Erlangen, Germany, 91054 Contact: Dimitre Staykov, PD Dr. +4991318533001 dimitre.staykov@uk-erlangen.de Less << |
NCT02998879 | Alpha-Mannosidosis | Phase 2 | Recruiting | February 2020 | Austria ... More >> Recruiting Wien, Austria Denmark Recruiting Copenhagen, Denmark France Recruiting Lyon, France Germany Not yet recruiting Hamburg, Germany Recruiting Mainz, Germany Italy Not yet recruiting Trieste, Italy Less << |
NCT02865434 | Arthritis, Rheumatoid | Phase 1 Phase 2 | Active, not recruiting | December 2018 | United States, Ohio ... More >> Kettering Medical Center Kettering, Ohio, United States, 45429 Less << |
NCT02997462 | - | Active, not recruiting | December 2019 | United States, Michigan ... More >> University of Michigan Health System Ann Arbor, Michigan, United States, 48109 Less << | |
NCT03236272 | - | Recruiting | December 31, 2020 | China ... More >> Emergency Department, Xinqiao Hospital, Third Military Medical University Recruiting Chongqing, China Contact: HU MINGDONG, MD Less << | |
NCT02478840 | Alpha-Mannosidosis | Phase 3 | Completed | - | Denmark ... More >> Center for Metabolic Diseases, Department of Clinical Genetics, Juliane Marie Centre, Copenhagen University Hospital, Blegdamsvej 9 Copenhagen, Denmark, DK-2100 Less << |
NCT00674271 | - | Unknown | May 2018 | Denmark ... More >> Medical Department M, Aarhus University Hospital Aarhus C, Denmark, 8000 Less << | |
NCT03436134 | Kidney Transplantation ... More >> Antibody Mediated Rejection Less << | Not Applicable | Not yet recruiting | March 1, 2021 | France ... More >> Grenoble Alpes University Hospital Not yet recruiting La Tronche, France, 38700 Contact: Lionel Rosating, PHD 0476767022 ext 0033 lrostaing@chu-grenoble.fr Contact: Paolo Malvezzi, MD 0476767022 ext 0033 Pmalvezzi@chu-grenoble.fr Principal Investigator: lionel Rostaing, PHD Sub-Investigator: Paolo Malvezzi, MD Less << |
NCT02332616 | Osteoarthrosis | Phase 3 | Completed | - | Denmark ... More >> Bispebjerg Hospital Copenhagen NV, Denmark, 2400 Less << |
NCT01349738 | - | Unknown | May 2013 | United States, California ... More >> Scripps Green Hospital La Jolla, California, United States, 92037 Less << | |
NCT02402803 | - | Recruiting | October 2019 | United States, California ... More >> Cedars Sinai Medical Center Recruiting Los Angeles, California, United States, 90048 Contact: Ying Mou, PhD 310-248-7669 ying.mou@cshs.org Contact: Sophie Yoo, MS 424-315-4306 Jihye.Yoo@cshs.org Principal Investigator: C. Noel Bairey Merz, MD Less << | |
NCT00984516 | Cicatrix Woun... More >>d-healing Less << | Phase 2 | Completed | - | United Kingdom ... More >> Renovo Manchester, United Kingdom, M13 9XX Less << |
NCT03332940 | Nonalcoholic Steatohepatitis ... More >> NASH - Nonalcoholic Steatohepatitis Less << | Phase 1 | Active, not recruiting | December 2018 | United States, Ohio ... More >> Kettering Medical Center Kettering, Ohio, United States, 45429 Less << |
NCT01906229 | - | Terminated(Slow enrollment and... More >> therefore not possible to reach the estimated enrollment) Less << | - | Denmark ... More >> Intensive Care Unit, 4131, Rigshospitalet Copenhagen Ø, Denmark, 2100 Less << | |
NCT00688389 | - | Recruiting | December 31, 2020 | Taiwan ... More >> Kaoshing Medical University Chung-Ho Memorial Hospital Recruiting Kaohsiung, Taiwan Contact: Jih-Jin Tsai, MD 886-7-312-1101 ext 5677 jijits@cc.kmu.edu.tw Less << | |
NCT00957736 | - | Terminated(study closed premat... More >>urely upon PI's departure from VICC) Less << | - | United States, Tennessee ... More >> Vanderbilt-Ingram Cancer Center - Cool Springs Nashville, Tennessee, United States, 37064 Vanderbilt-Ingram Cancer Center at Franklin Nashville, Tennessee, United States, 37064 Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232-6838 Less << | |
NCT03157167 | Kaposi Sarcoma ... More >> HIV Infections Less << | Phase 1 | Recruiting | March 2019 | United States, California ... More >> Zuckerberg San Francisco General Hospital Recruiting San Francisco, California, United States, 94143 Contact: Toby A Maurer, MD maurert@derm.ucsf.edu Principal Investigator: Toby A Maurer, MD Less << |
NCT00006134 | - | Completed | - | United States, Alabama ... More >> University of Alabama Comprehensive Cancer Center Birmingham, Alabama, United States, 35294 United States, Texas University of Texas Medical Branch Galveston, Texas, United States, 77555-0209 University of Texas Health Science Center - Houston Houston, Texas, United States, 77225 Less << | |
NCT00001702 | - | Completed | - | United States, Alabama ... More >> University of Alabama Birmingham, Alabama, United States United States, Maryland National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << | |
NCT01359384 | - | Unknown | May 2012 | Germany ... More >> Children's Hospital, Goethe-University Not yet recruiting Frankfurt a. Main, Hessen, Germany, 60590 Contact: Martin Rosewich, MD Martin.Rosewich@kgu.de Less << | |
NCT00001701 | - | Completed | - | United States, Alabama ... More >> University of Alabama Birmingham, Alabama, United States Less << | |
NCT03597152 | Recurrent Urinary Tract Infect... More >>ion Less << | Not Applicable | Not yet recruiting | December 31, 2020 | - |
NCT01889693 | - | Completed | - | Korea, Republic of ... More >> Korea University Guro Hospital Seoul, Korea, Republic of, 152-703 Less << | |
NCT01275066 | - | Completed | - | - | |
NCT01680575 | - | Recruiting | May 2018 | Korea, Republic of ... More >> Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center Recruiting Seoul, Korea, Republic of, 138-736 Contact: Jeong-Yeol Park, M.D., Ph.D. Less << | |
NCT01275066 | MPS IV A | Phase 3 | Completed | - | - |
NCT00197847 | - | Unknown | - | Denmark ... More >> Department of Intensive Care Copenhagen, Copenhagen Couty, Denmark, DK-2730 Less << | |
NCT01893489 | Atherosclerosis ... More >> Carotid Atherosclerosis Noninvasive Imaging of Atherosclerosis Less << | Phase 1 | Completed | - | Korea, Republic of ... More >> Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul, Korea, Republic of, 110-744 Korea University Guro Hospital Seoul, Korea, Republic of, 152-703 Less << |
NCT02894931 | Dietary Habits ... More >> Serum; Disease Macrophage Atherogenicity Atherosclerosis Less << | Not Applicable | Unknown | August 2018 | Israel ... More >> Rambam Health care center Recruiting Haifa, Israel, 320000 Contact: Niroz Abu-Saleh, PhD 972504278858 asniroz@gmail.com Less << |
NCT03641690 | - | Completed | - | - | |
NCT02931513 | - | Recruiting | June 2021 | Denmark ... More >> Department of Hepatology and Gastroenterology, Aarhus University Hospital, Denmark Recruiting Aarhus C, Region Midtjylland, Denmark, 8000 Contact: Lars Bossen, PhD-student +45 2280 0676 larsbossen@clin.au.dk Less << | |
NCT02924701 | - | Recruiting | June 2021 | Denmark ... More >> Department of Hepatology and Gastroenterology, Aarhus University Hospital, Denmark Recruiting Aarhus C, Region Midtjylland, Denmark, 8000 Contact: Lars Bossen, PhD-student +45 2280 0676 larsbossen@clin.au.dk Less << | |
NCT02635321 | - | Completed | - | Denmark ... More >> Copenhagen Neuromuscular Center Copenhagen, Denmark, 2100 Less << | |
NCT03077711 | Urinary Tract Infections, Recu... More >>rrent Less << | Phase 4 | Active, not recruiting | June 2019 | United States, Illinois ... More >> NorthShore Univeristy HealthSystem Skokie, Illinois, United States, 60076 Less << |
NCT00001648 | - | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << | |
NCT01919931 | - | Completed | - | Belgium ... More >> Universitair Ziekenhuis Leuven Leuven, Flemish Brabant, Belgium, 3000 Less << | |
NCT00648102 | Breast Cancer ... More >> Colorectal Cancer Pancreatic Cancer Bladder Cancer Ovarian Cancer Less << | Phase 1 | Completed | - | United States, Michigan ... More >> Henry Ford Health System Detroit, Michigan, United States, 48202 United States, North Carolina Duke University Durham, North Carolina, United States, 27710 Carolina BioOncology Institute Huntersville, North Carolina, United States, 28078 Less << |
NCT00388999 | Multiple Myeloma | Phase 1 | Completed | - | United States, Arkansas ... More >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205 Less << |
NCT00709462 | Breast Cancer ... More >> Colorectal Cancer Pancreatic Cancer Bladder Cancer Ovarian Cancer Less << | Phase 1 | Completed | - | United States, Michigan ... More >> Henry Ford Health System Detroit, Michigan, United States, 48202 United States, North Carolina Duke University Durham, North Carolina, United States, 27710 Carolina BioOncology Institute Cancer Huntersville, North Carolina, United States, 28078 Less << |
NCT02702765 | Wilsons Disease | Not Applicable | Recruiting | February 2020 | Denmark ... More >> Department of Hepatology and Gastroenterology, Aarhus University Hospital Recruiting Aarhus, Denmark, 8000 Contact: Jessica Björklund, Research-year student 004560748993 jebjoe@rm.dk Less << |
NCT00415311 | Liver Transplantation | Phase 1 | Terminated(Sponsor decision to... More >> terminate the study) Less << | - | United States, California ... More >> University of California San Francisco San Francisco, California, United States, 94143 United States, Nebraska Nebraska Medical Center Omaha, Nebraska, United States, 68198-7400 United States, New York Mount Sinai School of Medicine New York, New York, United States, 10029 United States, Tennessee Vanderbilt University Nashville, Tennessee, United States, 372321 Less << |
NCT00520325 | Cancer Hemato... More >>logic Diseases Fever Neutropenia Less << | Phase 1 | Withdrawn(Sponsor decision to ... More >>terminate the study) Less << | - | - |
NCT00664352 | Wound | Phase 1 Phase 2 | Completed | - | United Kingdom ... More >> 09Clinical Trials Unit, Renovo Limited Manchester, United Kingdom, M13 9XX Less << |
NCT03457038 | Septic Shock | Not Applicable | Recruiting | January 2019 | France ... More >> University Hospital Toulouse Recruiting Toulouse, France, 31059 Contact: Eric Oswald, MD 5 67 69 04 17 ext 33 oswald.e@chu-toulouse.fr Contact: Isabelle Olivier, PhD 5 61 77 70 51 ext 33 olivier.i@chu-toulouse.fr Less << |
NCT00000886 | HIV Infections | Phase 1 | Completed | - | United States, New York ... More >> Univ. of Rochester AVEG Rochester, New York, United States United States, Tennessee Vanderbilt Univ. Hosp. AVEG Nashville, Tennessee, United States, 37232 United States, Washington UW - Seattle AVEG Seattle, Washington, United States, 98144 Less << |
NCT00984854 | Cicatrix Re-e... More >>pithelialisation Less << | Phase 1 | Completed | - | United Kingdom ... More >> Renovo Manchester, United Kingdom, M13 9XX Less << |
NCT00854412 | Obesity Weigh... More >>t Loss Less << | Not Applicable | Completed | - | - |
NCT00678028 | - | Completed | - | Israel ... More >> Ha'Emek Medical Center Afula, Israel, 18101 Less << | |
NCT00886496 | Fever, Sweats, and Hot Flashes... More >> Infection Leukemia Lymphoma Myelodysplastic Syndromes Neutropenia Unspecified Childhood Solid Tumor, Protocol Specific Less << | Phase 1 | Withdrawn(No participants enro... More >>lled. IND withdrawn.) Less << | - | United States, California ... More >> Children's Hospital of Orange County Orange, California, United States, 92868 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010-2970 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Less << |
NCT03753451 | Periodontal Diseases | Not Applicable | Completed | - | Brazil ... More >> INCOR- Heart Institute Sao Paulo, São Paulo, Brazil, 05403900 INCOR - Heart Institute São Paulo, Brazil, 05403-900 Less << |
NCT03395288 | Urinary Tract Infections | PHASE2|PHASE3 | TERMINATED | 2020-04-25 | Washington University School o... More >>f Medicine, Saint Louis, Missouri, 63110, United States Less << |
NCT01014494 | Tendon Injuries | Not Applicable | Unknown | December 2011 | United Kingdom ... More >> Mr P Gillespie Recruiting Addenbrooke's Hospital, Cambridge, Cambridge, United Kingdom, CB2 0QQ Contact: Patrick Gillespie 01223 274632 Patrick.gillespie@addenbrookes.nhs.uk University Hospital of South Manchester NHS Foundation Trust Recruiting Manchester, Greater Manchester, United Kingdom, M23 9LT Contact: Miss V C Lees +44 (0) 161 291 6648 Principal Investigator: Vivien C Lees Mr F Schreuder Recruiting The Lister Hospital, Stevenage, Hertfordshire, United Kingdom Contact: Mr Schreuder 01438 781162 Fred.schreuder@nhs.net Mr R Dunn Recruiting Salisbury District Hospital, Salisbury, United Kingdom, SP2 8BJ Contact: Roderick Dunn 01722 336262 ext 3555 sue.dubber@salisbury.nhs.uk Mr D Warwick Recruiting Southampton General Hospital, Southampton, United Kingdom, SO16 6YD Contact: David Warwick 023 8079 5212 davidjwarwick@btinternet.com Contact: Elaine Hayward 02380 794 989 elaine.hayward@suht.swest.nhs.uk Royal London Hospital, Barts and The London Hospital Recruiting London, United Kingdom, E1 1BB Contact: Kamal El-Ali 07986 693062 Kamal.El-Ali@bartsandthelondon.nhs.uk Principal Investigator: Raj Ragoowansi Sub-Investigator: Kamal El Ali Royal Free Hospital Recruiting London, United Kingdom, NW3 2QG Contact: Donald Dewar 020 7794 0500 ext 31302 Principal Investigator: Donald Dewar Chelsea & Westminster Hospital Recruiting London, United Kingdom, SW10 9NH Contact: Mr Chakrabarty 020 8237 2777 ext 55490 khchakrabarty@yahoo.com Contact: Beryl De Souza bds@dr.com Principal Investigator: Kaushik Chakrabarty Sub-Investigator: Beryl De Souza Abertawe Bro Morgannwg University Nhs Trust Recruiting Swansea, United Kingdom, SA12 7BR Contact: Mr D Boyce +44 (0) 1792 703722 Principal Investigator: Mr D Boyce Less << |
NCT01808755 | - | Completed | - | - | |
NCT02823132 | - | Completed | - | France ... More >> Centre Hospitalier Universitaire Dijon, France, 21079 Less << | |
NCT03497598 | Urinary Tract Infections | Phase 4 | Recruiting | June 2021 | Switzerland ... More >> Kantonsspital Aarau Recruiting Aarau, Switzerland, 5001 Contact: Gloria Ryu, Dr. med Less << |
NCT01808755 | Recurrent Urinary Tract Infect... More >>ion Less << | Phase 3 | Completed | - | Italy ... More >> Urology Department Fondazione IRCCS Policlinico San Matteo Pavia, Italy, 27100 Less << |
NCT02397291 | IUGR Pregnanc... More >>y Less << | Not Applicable | Suspended | June 2020 | United States, Colorado ... More >> University of Colorado Denver Anschutz Medical Campus Aurora, Colorado, United States, 80045 Less << |
NCT02490046 | Multiple Sclerosis ... More >> Recurrent Urinary Tract Infections Less << | Phase 1 | Unknown | November 2015 | United Kingdom ... More >> The National Hospital for Neurology and Neurosurgery Recruiting London, United Kingdom, WC1N 3BG Contact: Jalesh Panicker, MD, FRCP 020 344 84713 j.panicker@ucl.ac.uk Contact: Véronique Phé, MD 020 344 84713 Veronique.Phe@uclh.nhs.uk Sub-Investigator: Mahreen Pakzad, FRCS Principal Investigator: Jalesh Panicker, MD, FRCP Sub-Investigator: Véronique Phé, MD Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
5.55mL 1.11mL 0.56mL |
27.75mL 5.55mL 2.78mL |
55.51mL 11.10mL 5.55mL |
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Dissolving Methods |
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
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