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[ CAS No. 347174-05-4 ] {[proInfo.proName]}

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Chemical Structure| 347174-05-4
Chemical Structure| 347174-05-4
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Product Details of [ 347174-05-4 ]

CAS No. :347174-05-4 MDL No. :MFCD08072959
Formula : C15H22N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :UJHBVMHOBZBWMX-UHFFFAOYSA-N
M.W : 262.34 Pubchem ID :4068248
Synonyms :
Fer-1

Safety of [ 347174-05-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 347174-05-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 347174-05-4 ]
  • Downstream synthetic route of [ 347174-05-4 ]

[ 347174-05-4 ] Synthesis Path-Upstream   1~7

  • 1
  • [ 87815-77-8 ]
  • [ 347174-05-4 ]
YieldReaction ConditionsOperation in experiment
100% With hydrogen In methanol for 72 h; The nitro derivative from above (24.28 g, 83 mmol) was hydrogenated (1 atm H2) over 20percent Pd(OH)2 on carbon (200 mg) in MeOH (150 mL) for 3 days. The catalyst was removed by filtration and volatiles removed under reduced pressure to give the title diamine (21.72 g, 100percent yield) as a dark purple solid.
85% With 10% palladium hydroxide on charcoal; hydrogen In methanol at 20℃; for 17 h; General procedure B (hydrogenolysis) [0274] The ethyl 4-(substituted-amino)-3-nitrobenzoates (130 mg, 0.445 mmol) were dissolved in MeOH (10 mL) and hydrogenated (H2 gas) over 10percent Pd(OH)2 on charcoal (90 mg) for 17 hours at room temperature. The solution was filtered through a pad of celite, and volatiles were removed under vacuum. The residue was purified by flash-column chromatography on silica gel to provide the desired Ferrostatin-1 derivatives. General procedure C (reductive amination reaction) (Abdel-Magid et al., 1996)
Reference: [1] Patent: US2003/236251, 2003, A1, . Location in patent: Page 20
[2] Synthesis, 2003, # 11, p. 1683 - 1692
[3] Journal of the American Chemical Society, 2014, vol. 136, # 12, p. 4551 - 4556
[4] Patent: WO2015/84749, 2015, A1, . Location in patent: Paragraph 0274; 0280
[5] Patent: WO2005/121132, 2005, A1, . Location in patent: Page/Page column 40
[6] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 1859 - 1863
[7] Patent: WO2005/12288, 2005, A1, . Location in patent: Page/Page column 87; 127
[8] Patent: US2011/152260, 2011, A1, . Location in patent: Page/Page column 16
[9] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 22, p. 5315 - 5320
  • 2
  • [ 16588-16-2 ]
  • [ 347174-05-4 ]
Reference: [1] Synthesis, 2003, # 11, p. 1683 - 1692
[2] Journal of the American Chemical Society, 2014, vol. 136, # 12, p. 4551 - 4556
[3] Patent: WO2015/84749, 2015, A1,
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 22, p. 5315 - 5320
[5] Patent: WO2005/121132, 2005, A1,
  • 3
  • [ 453-71-4 ]
  • [ 347174-05-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 1859 - 1863
[2] Patent: US2011/152260, 2011, A1,
  • 4
  • [ 367-80-6 ]
  • [ 347174-05-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 1859 - 1863
[2] Patent: US2011/152260, 2011, A1,
  • 5
  • [ 108-91-8 ]
  • [ 347174-05-4 ]
Reference: [1] Journal of the American Chemical Society, 2014, vol. 136, # 12, p. 4551 - 4556
[2] Patent: WO2015/84749, 2015, A1,
[3] Patent: WO2005/121132, 2005, A1,
  • 6
  • [ 100-52-7 ]
  • [ 87815-77-8 ]
  • [ 347174-05-4 ]
Reference: [1] Organic Process Research and Development, 2012, vol. 16, # 1, p. 96 - 101
  • 7
  • [ 96-99-1 ]
  • [ 347174-05-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 22, p. 5315 - 5320
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