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CAS No. :	347174-05-4
Formula :	C₁₅H₂₂N₂O₂
M.W :	262.34
SMILES Code :	O=C(OCC)C1=CC=C(NC2CCCCC2)C(N)=C1
Synonyms :	Fer-1
MDL No. :	MFCD08072959
InChI Key :	UJHBVMHOBZBWMX-UHFFFAOYSA-N
Pubchem ID :	4068248

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

mouse primary microglial cells (mPMs)	10 μM	1 h	Inhibited HIV-1 Tat-mediated microglial ferroptosis, reduced lipid peroxidation and the release of proinflammatory cytokines.	PMC10106521
H9C2 cells	2 μM		reduced DOX-induced cell death by approximately 50%	PMC10400469
H9C2 cells	2 μM		fully rescued erastin-induced cell death	PMC10400469
FHs74Int cells	5 μM	120 h	Fer-1 significantly reduced IR-induced cell death and lipid peroxidation levels in the presence of AA	PMC10466894
FHs74Int cells	5 μM	72 h	Fer-1 significantly reduced IR-induced lipid peroxidation levels in the presence of AA	PMC10466894
primary cultured adult mouse cardiomyocytes (PAMCs)	2 μM	48 h	To explore whether E-Exe preconditioning of PAMCs could resist DIC injury-induced ferroptosis, results showed that Fer-1 significantly alleviated DIC injury	PMC10878110
HTR-8/SVneo cells	5 μM	36 h	Blocking ferroptosis significantly reversed the shFTL-induced decrease in cell viability and improved the changes in most ferroptotic marker concentrations/activities.	PMC9706170
L02 cells	5 μM	1 h	Fer-1 pretreatment significantly increased the protein expression of GPX4 and Ferritin, restored the decreased GSH levels and elevated MDA content caused by EC treatment, and alleviated the cytotoxicity induced by EC.	PMC9142717
RD cells	100 μM	36 h	Inhibited lipid peroxidation and cell death induced by CV-A6 infection	PMC8764547
HUVECs	1 μM	24 h	Inhibited ZnONPs-induced cell death and lipid peroxidation	PMC8726675
EA.hy926 cells	1 μM	24 h	Inhibited ZnONPs-induced cell death and lipid peroxidation	PMC8726675
LLC-MK2 cells	40 μM	2-5 days	Inhibited lipid peroxidation induced by CoV-229E infection	PMC8764547
NRK49F cells	5 μM	1 h	Restored GPX4 protein expression	PMC9894909
HK-2 cells	5 μM	1 h	Restored GPX4 protein expression	PMC9894909
ZR-75-1	10 µM	1 h	Fer-1 significantly attenuated IR-induced cell death in ER-positive ZR-75-1 cells	PMC8888677
oligodendrocytes (OLs)	100 nM		Protected oligodendrocytes from cystine deprivation-induced death	PMC3985476
HT-1080 fibrosarcoma cells	1 μM	7.5 h	Inhibited erastin-induced lipid peroxidation and cell death	PMC3985476
human monocyte-derived macrophages	10 µM	4 days	inhibited Mtb-induced macrophage necrosis and lipid peroxidation	PMC6400546
VSC4.1 cell line	1 μM	12 h	To evaluate the protective effect of Ferrostatin-1 on RSL3-induced cell death, it was found that Ferrostatin-1 significantly increased cell viability	PMC11103787
HT22 cell line	1 μM	12 h	To evaluate the protective effect of Ferrostatin-1 on RSL3-induced cell death, it was found that Ferrostatin-1 significantly increased cell viability	PMC11103787
Huc-MSCs	1 μM	24 h	To evaluate the effect of Ferrostatin-1 on RSL3-induced intracellular GSH levels, it was found that Ferrostatin-1 significantly increased GSH levels	PMC11103787
NRK49F cells	1 μM	1 h	Used to inhibit cell death induced by CMPF. The results showed that pretreatment with Ferrostatin-1 significantly reduced ROS production induced by CMPF	PMC9894909
HK-2 cells	1 μM	1 h	Used to inhibit cell death induced by CMPF. The results showed that pretreatment with Ferrostatin-1 significantly reduced ROS production induced by CMPF	PMC9894909
MCF-7	10 µM	1 h	Fer-1 significantly attenuated IR-induced cell death in ER-positive MCF-7 and ZR-75-1, but not in ER-negative MDA-MB-231 cells	PMC8888677
BMSCs	10 μM	12 h	To evaluate the inhibitory effect of Ferrostatin-1 on bacteria-induced ferroptosis in BMSCs. Results showed that Fer-1 significantly reduced the mortality rate of BMSCs and decreased the accumulation of lipid peroxides and ferrous ions.	PMC11497072
LO2 cells	10 μM	24 h	Inhibited ferroptosis and alleviated CM-IH-induced lipid accumulation and ferroptosis phenotype	PMC11538716
HepG2 cells	10 μM	24 h	Inhibited ferroptosis and alleviated CM-IH-induced lipid accumulation and ferroptosis phenotype	PMC11538716
murine bone marrow-derived macrophages (BMDMs)	10 µM	4 days	inhibited Mtb-induced macrophage necrosis and lipid peroxidation	PMC6400546
A549 cells	2 μM	2 hours	To investigate the effect of iFSP1 on PAM-induced ferroptosis, results showed that iFSP1 enhanced PAM-induced ferroptosis.	PMC8901787
H1299 cells	2 μM	2 hours	To investigate the effect of iFSP1 on PAM-induced ferroptosis, results showed that iFSP1 enhanced PAM-induced ferroptosis.	PMC8901787

mice	DOX-induced cardiomyopathy model	subcutaneous injection	1 mg/kg	daily for 7 days	significantly rescued DOX-induced cardiac dysfunction, fibrosis, and oxidative stress	PMC10400469
C57BL/6J mice	radiation-induced intestinal injury model	intraperitoneal injection	5 mg/kg	once daily for 14 days	Fer-1 significantly improved the survival rate of mice and alleviated radiation-induced intestinal fibrosis	PMC10466894
Mice	Bone cancer pain model	Intraperitoneal injection	10 mg/kg	Once daily for 20 consecutive days	FER-1 alleviated mechanical allodynia and thermal hyperalgesia in a mouse model of bone cancer pain and reduced spontaneous pain behavior. Furthermore, FER-1 inhibited the pain-associated activation of ERK1/2 and COX-2 expression and prevented the loss of GABAergic interneurons.	PMC10141498
mice	Doxorubicin-induced cardiotoxicity (DIC) model	intraperitoneal injection	1 mg/kg	once daily for 2 weeks	To explore the influence of ferroptosis induced by DIC injury on E-Exe preconditioning, results showed that Fer-1 significantly alleviated DIC injury	PMC10878110
Rats	FTL knockdown pregnant rat model	Intraperitoneal injection	2 μM/kg	Every two days until GD17.5	Blocking ferroptosis significantly reversed the shFTL-induced PE-like phenotypes, including improvements in glomerular morphological damage, 24-hour proteinuria, and blood pressure.	PMC9706170
Balb/c mice	EC-induced liver injury model	Intraperitoneal injection	1 mg/kg	21 consecutive days	Fer-1 pretreatment significantly increased and liver index in mice, decreased serum AST and ALT levels, alleviated EC-induced liver inflammation and oxidative stress, and restored the protein expression of GPX4 and Ferritin.	PMC9142717
Mice	Pulmonary ZnONPs exposure model	Intraperitoneal injection	10 mg/kg	Single dose, lasted for 3 days	Significantly reversed ZnONPs-induced vascular injury	PMC8726675
Mice	Acute osteomyelitis model	Intraperitoneal injection	10 mg/kg	Once daily for 3 days	To evaluate the inhibitory effect of Ferrostatin-1 on bacteria-induced ferroptosis in BMSCs in vivo. Results showed that Fer-1 significantly reduced the levels of lipid peroxides in BMSCs.	PMC11497072
C57BL/6 mice	NAFLD model induced by high-fat diet and chronic intermittent hypoxia	Intraperitoneal injection	1 mg/kg	Once daily for four weeks	Inhibited ferroptosis and alleviated HFD and CIH-induced liver function injury and lipid accumulation	PMC11538716
C57BL/6 mice	Mtb H37Rv infection model	Intraperitoneal injection	3 mg/kg	Once daily from day 15 to day 28 post-infection	Reduced pulmonary necrosis and bacterial load	PMC6400546

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CAS No.: 347174-05-4

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CAS No.: 347174-05-4

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed