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Chemical Structure| 353512-04-6 Chemical Structure| 353512-04-6

Structure of JAK2-IN-6
CAS No.: 353512-04-6

Chemical Structure| 353512-04-6

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JAK2-IN-6 is an effective selective JAK2 inhibitor, with an IC50 of 22.86 μg/mL. It lacks activity against JAK1 and JAK3 but exhibits anti-proliferative effects against cancer cells.

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Product Details of JAK2-IN-6

CAS No. :353512-04-6
Formula : C14H10ClN3OS2
M.W : 335.83
SMILES Code : O=C(C1=C(N)N=C(NC2=CC=CC=C2)S1)C3=CC=C(Cl)S3
MDL No. :MFCD03234340

Safety of JAK2-IN-6

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of JAK2-IN-6

epigenetics
RTK
JAK-STAT

Isoform Comparison

Biological Activity

Description
JAK2-IN-6, a multiple-substituted aminothiazole derivative, is a potent and selective inhibitor of JAK2, exhibiting an IC50 of 22.86 μg/mL. JAK2-IN-6 does not exhibit activity against JAK1 and JAK3. It demonstrates an anti-proliferative effect against cancer cells [1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.98mL

0.60mL

0.30mL

14.89mL

2.98mL

1.49mL

29.78mL

5.96mL

2.98mL

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