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[ CAS No. 3575-09-5 ] {[proInfo.proName]}

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Chemical Structure| 3575-09-5
Chemical Structure| 3575-09-5
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CAS No. :3575-09-5 MDL No. :MFCD00623590
Formula : C4H4N2OS Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 128.15 Pubchem ID :-
Synonyms :

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Signal Word: Class:N/A
Precautionary Statements: UN#:N/A
Hazard Statements: Packing Group:N/A

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 3575-09-5 ]
  • Downstream synthetic route of [ 3575-09-5 ]

[ 3575-09-5 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 3575-09-5 ]
  • [ 1452-15-9 ]
YieldReaction ConditionsOperation in experiment
85% at 325℃; for 1 h; General procedure: Into a 1L open reactor was added 500g of carboxylic acid raw material (chemically pure) and stirring was turned on (600 r/min) from the reactorThe bottom is continuously fed with ammonia gas (chemical purity, water content of 5.1percent by weight, flow rate of 100 g/min) to the carboxylic acid feed. After the reaction was allowed to proceed for TC hours at the reaction temperature TA, ammonia gas flow was stopped. The contents of the reactor were sampled and subjected to nuclear magnetic proton and elemental analysis to characterize the amide intermediate. Specific reaction conditions and characterization results are shown in Table A-1, Table A-2, Table A-3, Table A-4, Table A-5 and Table A-6. These characterization results show that the amide intermediates obtained have an extremely high purity (above 99percent).In this embodiment, the ammonia gas can be directly replaced with waste ammonia gas (from Yangzi Petrochemical Plant, containing approximately50wtpercent of ammonia gas, the rest were toluene, oxygen, nitrogen, steam, carbon monoxide, and carbon dioxide, and the flow rate of this waste ammonia was 130g/min).
7.6 g With triethylamine; trifluoroacetic anhydride In tetrahydrofuran at 0 - 20℃; for 18 h; To a solution of thiazole-4-carboxamide (10. Og, 67.1 mmol) in THF (150 mL) were slowly added triethylamine ( 42.1 mL, 302 mmol) and TFAA (19 mL, 134 mmol) at 0 °C successively. After being slowly warmed to rt and stirred for 18 hrs, the reaction mixture was diluted with H20 (100 mL) and extracted in DCM (50 mL) for three times. The combined organic phase was concentrated in vacuo and the residue was purified by column chromatography (eluting with PE/EA=5/1, v:v) to give thiazole-4-carbonitrile (7.6 g) as yellow oil.
Reference: [1] Patent: CN104557357, 2018, B, . Location in patent: Paragraph 0150; 0151; 0152; 0162
[2] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 6, p. 628 - 633
[3] Helvetica Chimica Acta, 1957, vol. 40, p. 554,558
[4] Bulletin de la Societe Chimique de France, 1969, p. 4026 - 4031
[5] Journal of the Chemical Society, 1960, p. 916 - 925
[6] Patent: WO2018/83081, 2018, A1, . Location in patent: Page/Page column 42; 43
[7] Patent: WO2007/138343, 2007, A1, . Location in patent: Page/Page column 7; 8
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