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Chemical Structure| 364762-86-7 Chemical Structure| 364762-86-7

Structure of TD-198946
CAS No.: 364762-86-7

Chemical Structure| 364762-86-7

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TD-198946, a thienoindazole derivative, is a potent chondrogenic agent.

Synonyms: TD-198946

4.5 *For Research Use Only !

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Product Details of TD-198946

CAS No. :364762-86-7
Formula : C27H22N4O3S
M.W : 482.55
SMILES Code : CN1N=CC2=C1C1=C(OC3=CC=C(OCC4=CC=C5C=CC=CC5=N4)C=C3)SC(C(N)=O)=C1CC2
Synonyms :
TD-198946
MDL No. :MFCD28044311
InChI Key :QGAMAWMLTUNPAB-UHFFFAOYSA-N
Pubchem ID :9826550

Safety of TD-198946

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.07mL

0.41mL

0.21mL

10.36mL

2.07mL

1.04mL

20.72mL

4.14mL

2.07mL

References

[1]Yano F, et al. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013 May;72(5):748-53.

[2]Yano F, et al. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis. 2014 Nov;73(11):2062-4.

[3]Yano F, et al. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials. 2013 Jul;34(22):5581-7.

[4]Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, Saito T, Hirata M, Chikuda H, Takato T, Kawaguchi H, Chung UI. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013 May;72(5):748-53

[5]Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung UI. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials. 2013 Jul;34(22):5581-7

[6]Kushioka J, Kaito T, Chijimatsu R, Okada R, Ishiguro H, Bal Z, Kodama J, Yano F, Saito T, Chung UI, Tanaka S, Yoshikawa H. The small compound, TD-198946, protects against intervertebral degeneration by enhancing glycosaminoglycan synthesis in nucleus pulposus cells. Sci Rep. 2020 Aug 25;10(1):14190

[7]Kobayashi M, Chijimatsu R, Hart DA, Hamamoto S, Jacob G, Yano F, Saito T, Shimomura K, Ando W, Chung UI, Tanaka S, Yoshikawa H, Nakamura N. Evidence that TD-198946 enhances the chondrogenic potential of human synovium-derived stem cells through the NOTCH3 signaling pathway. J Tissue Eng Regen Med. 2021 Feb;15(2):103-115

 

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