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CAS No. : | 36791-04-5 | MDL No. : | |
Formula : | C8H12N4O5 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | IWUCXVSUMQZMFG-AFCXAGJDSA-N |
M.W : | 244.20 | Pubchem ID : | 37542 |
Synonyms : |
Ribasphere;NSC 163039;Ribavirin, Copegus, Rebetol, Virazole, ICN-1229;Tribavirin;RTCA;ICN-1229
|
Chemical Name : | 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide |
Num. heavy atoms : | 17 |
Num. arom. heavy atoms : | 5 |
Fraction Csp3 : | 0.62 |
Num. rotatable bonds : | 3 |
Num. H-bond acceptors : | 7.0 |
Num. H-bond donors : | 4.0 |
Molar Refractivity : | 51.06 |
TPSA : | 143.72 Ų |
GI absorption : | Low |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -9.1 cm/s |
Log Po/w (iLOGP) : | 0.35 |
Log Po/w (XLOGP3) : | -1.85 |
Log Po/w (WLOGP) : | -3.34 |
Log Po/w (MLOGP) : | -2.94 |
Log Po/w (SILICOS-IT) : | -2.9 |
Consensus Log Po/w : | -2.14 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 1.0 |
Egan : | 1.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -0.21 |
Solubility : | 151.0 mg/ml ; 0.619 mol/l |
Class : | Very soluble |
Log S (Ali) : | -0.65 |
Solubility : | 54.7 mg/ml ; 0.224 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | 1.76 |
Solubility : | 14000.0 mg/ml ; 57.3 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 3.89 |
Signal Word: | Danger | Class: | N/A |
Precautionary Statements: | P201-P202-P280-P312-P405-P501 | UN#: | N/A |
Hazard Statements: | H302-H341-H360 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With pyridine; at 20℃; for 22h; | Synthesis of 2? 3? 5?-O-triacetyl-(3-D-ribothranosyl)-1 ,2,4-triazole-3-carboxamide 8 A suspension of <strong>[36791-04-5]ribavirin</strong> 1 (568 mg, 2.33 mmol) in aceticanhydride (4 mE) and pyridine (1 mE) was stirred at roomtemperature for 22 hours. The mixture was concentratedunder reduced pressure and the residue was dried under highvacuum to afford the product in quantitative yield. |
100% | With pyridine; at 20℃; | A suspension of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (<strong>[36791-04-5]Ribavirin</strong>) (28.4 g, 116.4 mmol) (5) in acetic anhydride (200 mL) and pyridine (50 mL) was stirred at room temperature overnight. The resulting clear solution was concentrated in vacuo to yield a clear foam (43.1 g, quantitive). This foam was homogenous on TLC and used directly for the next step without purification. A small amount was purified by flash chromatography to yield an analytical sample; 1H NMR (300 MHz), DMSO-d6) delta 2.01, 2.08, 2.09 (3s, 9H, COCH3), 4.10 (m, 1H), 3.52 (m, 2H), 5.58 (t, 1H), 5.66 (in, 1H); 6.33 (d, 1H, J.=3.0 Hz, C1H), 7.73, 7.92, (2 s, 2H, CONH2), 8.86 (s, 1H, C5H triazole). Anal. (C10H18N4O8) C, H, N. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56.5% | With pyridine; iodine; triphenylphosphine; at 20℃; for 12h; | solution of PPh3 (17.48 g, 66.6 mmol) and I2 (15.61 g, 61.5 mmol) in pyridine (100 mL) was stirred at R.T. for 20 min and then compound 14-1 (10.0 g, 41.0 mmol) was added. The reaction mixture was stirred at R.T. for 12 hours, concentrated to dryness, and co-evaporated with toluene twice. The crude product was purified on a silica gel column (DCM/MeOH=20:1 to 7.5:1) to afford compound 14-2 (8.21 g, 56.5%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51.2% | With ammonium hydroxide; dihydrogen peroxide;platinum; In methanol; | (C) 1-(beta -D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (Method 3) A mixture of 3-cyano-1-(2,3,5 -tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazole (705 mg., 2.0 mmole), 28% aqueous ammonia (20 ml.) and 30% hydrogen peroxide (3.0 ml.) was stirred at 25 for 6 hrs. An additional 3.0 ml. portion of 30% hydrogen peroxide was then added and stirring at 25 was continued for 12 hrs. The excess hydrogen peroxide was destroyed by addition of platinum black, the solution was filtered, the filtrate was evaporated to dryness. The residue was dissolved in methanol and silic gel (5.0 g.) was added to the solution. The solvent was removed and the silica gel mixture was applied to a silica gel column. Elution with ethyl acetate-methanol (1:1) provided 1-(beta -D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (250 mg., 51.2%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With sodium methylate; diethylamine; In methanol; at 80℃; for 6h; | To the condensation product, 50 g of diethylamine, 10 g of sodium methoxide, and 300 ml of methanol were added and stirred at 80 C. for 6 hours. The reaction solvent was distilled under reduced pressure, 400 ml of methanol was added to the remaining solid, and heated to 65 C. until the solid dissolved. Cooled to room temperature, filtered and dried 73.8 g of the resulting solid in a yield of 95%. HPLC purity was 99.95%. |
With ammonia; In methanol; at 20℃; for 4h; | Synthesis of ribavirin (I); To the residue thus obtained, 1000 ml of methanol and 64 g of gaseous ammonia are added and the mixture left for 4 hours at 20C while stirring; there is precipitation of product in the course of the reaction. Distillation under reduced pressure (200 mmHg; internal T 40C) is carried out to about half volume and 200 ml of water are added; heating to 60-70C is carried out until dissolved and 400 ml of methanol are added. The mixture is cooled to 0-5C for 4 hours and the solid is filtered over a Buchner filter while washing with methanol; 300 g of moist raw Ribavirin are obtained and this is crystallised without desiccation. | |
107.52 g | With ammonia; In methanol; for 5h;Autoclave; | Add 191.05g to the autoclave(0.5 mol) of 1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester and 2000 ml Methanol, the reactor was kept at a pressure of 2 kg at room temperature, and the reaction was carried out for 5 hours.Then, excess ammonia gas is recovered, the solvent is removed under reduced pressure, and the residue is recrystallized from ethanol to obtain 107.52 g of ribavirin product. |
With ammonia; In methanol; at 20℃; for 4h; | To the residue obtained, 1000 ml of methanol and 64.12g ammonia gas and the mixture was placed at 20 C for 4 h with stirring; The precipitation of the product occurs during the process of reflection. It was distilled to about half volume under reduced pressure (200 mmHg; internal temperature 40 C) and added to 200 ml of water; heated to 60-70 C until dissolved and 400 ml of methanol was added. The mixture was cooled to 0-5 C for 4 hours and the solid was filtered using a Buchner funnel. At the same time, it was washed with methanol; 302.22 g of a wet crude ribavirin was obtained, which was crystallized without drying. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; water; | 1-beta-Ribofuranosyl-1,2,4-triazole-3-carboamide (5): Methyl-1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl)-1,2,4-triazole-3-carboxylate (62 g, 161 mmol) was placed in a steel bomb and treated with freshly prepared methanolic ammonia (350 ml, prepared by passing dry HCL gas into dry methanol at 0 C. until saturation) at 0 C. The steel bomb was closed and stirred at room temperature for 18 h. The steel bomb was then cooled to 0 C., opened and the content evaporated to dryness. The residue was treated with dry ethanol (100 ml) and evaporated to dryness. The residue obtained was triturated with acetone to give a solid, which was filtered and washed with acetone. The solid was dried overnight at room temperature and dissolved in a hot EtOH (600 ml) and water (10 ml) mixture. The volume of the EtOH solution was reduced to 150 ml by heating and stirring on a hot plate. The hot EtOH solution on cooling provided colorless crystals, which were filtered, washed with acetone and dried under vacuum. Further concentration of the filtrate gave additional material. The total yield was 35 g (89%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With trichlorophosphate; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; water; | A. Preparation of <strong>[36791-04-5]Ribavirin</strong> 5'-Monophosphate The manufacture and synthesis <strong>[36791-04-5]Ribavirin</strong> (ICN Pharmaceuticals, Costa Mesa Calif.) are described in U.S. Pat. No. 4,211,771, incorporated herein by reference. A dry 1 L ml 3-neck round bottom flask, equipped with a stir bar, gas inlet adapter, and thermometer, was charged with 50 g <strong>[36791-04-5]Ribavirin</strong> (0.204 moles), 500 ml trimethyl phosphate, and 0.367 ml de-ionized water (0.0204 moles). The mixture was cooled under nitrogen with an ice/water bath. When the temperature reached 10 C., 23.3 ml phosphorous oxychloride was added, the flask was removed from the ice bath, and the mixture was stirred under nitrogen. After 30 min., the flask was cooled in the ice/water bath. When the temperature reached 10 C., the mixture was poured into a 2 L beaker containing 1000 ml ice water. The pH was adjusted to pH=9.0 using 4 M LiOH and the mixture was stirred overnight. After final adjustment to pH 9, the white precipitate that has formed is filtered away using a 0.2 mm filter. The mixture was evaporated at 40 C. under reduced pressure to 1 L. The solution was added to 1 L hot ethanol dropwise. The white precipitate was collected on a 2 L glass fritted funnel, coarse grade, washing the solid with two 100 ml portions of ethanol, re-suspending the solid each time. The product was dried under vacuum overnight, yield: 89 g. The solid was dissolved in 200 ml de-ionized water, and 5 g activated carbon was added. The mixture was filtered through a 0.2 mm filter, washing the carbon with 50 ml de-ionized water. The filtered solution was added dropwise to 1200 ml hot ethanol The mixture was cooled to room temperature, and the precipitate was collected on the 2 L glass fritted funnel. The solid was washed with 2*100 ml ethanol in the funnel, and dried under vacuum. Yield: 66.6 g. The dried product was dissolved in 200 ml de-ionized water. Amberlite IR-120 H.C.P. resin (H+ form) was added until the pH of the mixture reached pH=2.18. The resin was filtered off using a 0.2 mm filter, and the final solution was lyophilized. Yield: 54.8 g (0.160 moles), 78.5%, <strong>[36791-04-5]Ribavirin</strong> 5'-monophosphate. Elemental analysis indicates the product contains 1 mole water/mol <strong>[36791-04-5]ribavirin</strong> 5'-monophosphate. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide 150 mg of the beta anomer from example 3 was treated with 5 ml 80% aqueous trifluoroacetic acid for 10 min. The solution was then evaporated and the product was crystallized from EtOH to give 111 mg of product with mp 165-167. Anal. Calc for C8 H12 N4 05: C, 39.35; H, 4.95; N, 22.94. Found: C, 39.59; H, 4.82; N, 22.82 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; | (A) 1-(beta -D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (Method 1) A solution of 1-(2,3,5-tri-O-benzoyl-beta -D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (16.0 g., 28.0 mmole) in methanol (300 ml., presaturated with anhydrous ammonia at 0) was kept in a sealed pressure flask at 25 for 3 days. The solvent was removed and the product was crystallized from ethanol to give 6.7 g. (98%) of material with M.P. 174-176. Recrystallization of the product from aqueous ethanol provided a second crystalline form of the nucleoside with M.P. 166-168. Analysis.--Calcd. for C8 H12 N4 O5 (percent): C, 39.34; H, 4.95; N, 22.94. Found (percent): C, 39.08, H, 5.10; N, 22.67. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99.71% | With ammonia; at 20℃; under 5250.53 Torr; for 20h;Autoclave; Green chemistry; | Into a 2L clean stainless steel high pressure autoclave equipped with thermometer, vacuum pressure gauge and mechanical stirrer, add 50 g ribavirin condensate (II). On the feed cover, vacuum to the limit. And then with a dual piston pump through the flowmeter pump 300 g of liquid ammonia into the autoclave. Turn off the feed valve and feed pump. Using warm water elevate temperature to 20 C. The reaction was maintained at this temperature and kept at a pressure of 0.7 MPa for 20 h. After the maintained temperature reaction is finished, the temperature slowly, through the special ammonia compressor will boil off the ammonia into the liquid ammonia, the ammonia in the reactor after all off, to stop vapor ammonia, to obtain white solid (I) 31.6g folds purely, yield 99.71% (of (II) in order to condensate), white RBV crude product (I) by detecting the purity of 99.8% ( unitary method HPLC chromatographic area), |
97% | With ammonia; In methanol; at 0℃; for 2.5h; | Intermediate of ribavirin in a 500 mL four-necked flask equipped with mechanical stirring, thermometer and distillation unit[1-(2,3,5-Tri-O-acetyl-beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester] 100.0 g with 100 mL of methanol Mix and stir to form a uniform slurry, and pass ammonia gas at low temperature (0 C) until the slurry becomes transparent.Continue to feed a sufficient amount of ammonia and then react at 0 C for 2.5 h.Stop the ammonia gas, let stand, precipitate the solid, filter out the solid, and obtain the product.Ribavirin. The yield of the aminolysis reaction was 97%.The total yield of the two-step reaction was 79.5%. |
92.6% | With methanol; ammonia; at 10 - 20℃; for 18h;Autoclave; | In a 250 mL autoclave, 38.5 g of ribavirin condensate and 100 mL of methanol were added.Ammonia gas is introduced into the atmosphere at 5 atmospheres, and the temperature is maintained at 10-20C. After the completion of ammonia injection, the reaction is maintained for 18.0 hours.Then concentrate under reduced pressure to remove the solvent.Add methanol to dissolve, filter while hot, and place the filtrate in the refrigerator freezer overnight. Crystals precipitated, filtered, dried,22.4 g of ribavirin white crystals were obtained with a yield of 91.8%.The purity was 99.8% (HPLC).Same as Example 1. As a result, 22.4 g of ribavirin white crystals were obtained with a yield of 92.6% and a purity of99.9% (HPLC). |
90.0% | In methanol; | (B) 1-(beta -D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (Method 2) A solution of 1-(2,3,5-tri-O-acetyl-beta -D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (10.0 g., 26.0 mmole) in methanol (70 ml.) saturated at 0 with anhydrous ammonia was kept in a sealed pressure flask at 25 for 18 hrs. The product was crystallized from ethanol to give 1-(beta -D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (5.70 g., 90.0%). |
With ammonia; In methanol; at 20℃; | General procedure: A mixture of 3a (0.5 g) and methanol saturated with ammonia (15 mL) was stirred at room temperature for 5-6 h. The progress of the reaction was monitored by TLC (silicagel as solid phase, methanol: chloroform 1:4 as mobile phase). When the reaction was complete, the solvent was removed by distillation under reduced pressure and the residual solid was recrystallized from dichloromethane to give 0.29 g (87.1%) of 4a asa white solid with purity of 99.1% (HPLC). The procedure for the preparation of 4b was similar to 4a. 4b was obtained as a white solid with purity of 99.2% (HPLC). The physical data for compounds 3 and 4 were shown in Table 3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; water; | 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (5) Methyl-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxylate (62 g, 161 mmol) (3) was placed in a steel bomb and treated with freshly prepared methanolic ammonia (350 mL, prepared by passing dry ammonia gas into dry methanol at 0 C. until saturation) at 0 C. The steel bomb was closed and stirred at room temperature for 18 h. The steel bomb was cooled to 0 C., opened and the content evaporated to dryness. The residue was treated with dry EtOH (100 mL) and evaporated to dryness. The residue obtained was triturated with acetone to give a solid, which was filtered and washed with acetone. The solid was dried overnight at room temperature and dissolved in hot EtOH (600 mL) and water (10 mL) mixture. The volume of the EtOH solution was reduced to 150 mL by heating and stirring on a hot plate. The hot EtOH solution on cooling provided colorless crystals, which was filtered, washed with acetone and dried under vacuum. Further concentration of the filtrate gave additional material. Total yield: 35 g (89%); mp 177-179 C.; [alpha]20D-35.3 (c, 10, H2O); 1H NMR (Me2SO-d6): delta3.46 (m, 1H, C5'H), 3.60 (m, 1H, C5'H), 3.94 (m, 1H), C4'H), 4.12 (m, 1H) 4.34 (m, 1H), 4.95 (t, 1H, C5'OH), 5.22 (d, 1H), 5.60 (d, 1H), 5.80 (d, 1H, J=3.9 Hz, C1'H), 7.64 (bs, 1H, NH2), 7.84 (bs, 1H, NH2), 8.87 (s, 1H, C5H). 13C NMR (Me2SO-d6) delta61.8, 70.2, 74.4, 86.0, 91.6, 144.9, 157.4, 160.6. Anal. (C8H12N4O5) C, H, N. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With pyridine; at 20℃; for 23.5h; | Synthesis of 3,5-O-(1 , 1 ,3,3-tetraisopropyl-1 ,3-disi- loxanyl)-<strong>[36791-04-5]ribavirin</strong> 2 <strong>[36791-04-5]Ribavirin</strong> 1 (203.4 mg, 0.83 mmol) was mixed with pyridine (3.0 mE) at room temperature, and then 1 ,3-dichloro-1, 1,3,3-tetraisopropyldisiloxane (0.33 mE, 1.00 mmol) was added. The resulting mixture was stirred at room temperature for 23.5 hours. Water was added to quench the reaction and extracted with EtOAc (3x20 mE). The combined organic 25 solution was washed with brine (50 mE), dried over sodium sulfate, concentrated. The residue was purified by flash column chromatography on silica gel using MeOH/DCM (0-5%) to afford the product (369 mg, 91%). ?H-NMR (CDC13) 88.36 (s, 1H, C5H), 6.90 (bs, 1H, NH2), 5.90 (s, 1H, 30 C1H), 5.58 (bs, 1H, NH2), 4.66-4.61 (m, 1H), 4.45 (d, 1H), 4.17-3.97 (m, 3H), 2.93 (s, 1H), 1.00-0.98 (m, 28H). LC-Ms:487.3 MH.20 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87.0% | 84.0 mg (0.34 mmol) of lyophilized solid (Intermediate 5) were dissolved in 5.0 ml of distilled water. Thereafter 82.7 mg of <strong>[36791-04-5]ribavirin</strong>e (0.34 mmol) were added under slow stirring. The mixture was kept overnight at 4 C under slow stirring. After addition of 40.0 mg of sodium borohydride the reaction mixture was kept at room temperature under stirring during 1 hour. The mixture was then passed on a Dowex 50 (H+) column to convert the excess of sodium borohydride into boric acid. The elute was lyophilized. The lyophilized was then dissolved in a small aliquot of methanol and the filtrate was brought to dryness. This operation was repeated at least three times. The dried powder was then dissolved with a small aliquot of water and then lyophilized to yield the <n="41"/>final Compound 10. 140.62 mg of Compound 10 (M. W. 475.4) were collected (Yield: 87.0 %).The collected Compound was positive to resorcinol-HCI and TBA reactions. The FT-IR spectrum (A) of Compound10, drawn in Figure 4, compared to that (B) of the starting intermediate <strong>[36791-04-5]ribavirin</strong>e, shows the following references: a) amide I band: 1640 cm"1; b) amide II band: 1550 cm"1; c) primary amino groups: 600-800 cm"1, 1590-650 cm"1, 3330-3380 cm"1; secondary amino groups: 700-800 cm" 1J 1615 cm"1; 3300 cm"1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89.0% | 94.26 mg (0.34 mmol) of lyophilized solid (Intermediate 6) were dissolved in 5.0 ml of distilled water. Thereafter 82.7 mg of <strong>[36791-04-5]ribavirin</strong>e (0.34 mmol) were added under slow stirring. The mixture was kept overnight at 4 C under slow stirring. After addition of 40.0 mg of sodium borohydride the reaction mixture was kept during 1 hour under stirring and at room temperature. The mixture was then passed on a column Dowex 50 (H+) resin to convert the excess of sodium borohydride into boric acid. The elute was lyophilized. The lyophilized was then recovered with a small aliquot of methanol and the elute was brought again to <n="36"/>dryness. This operation was repeated at least three times. The dried solid was finally dissolved with a small aliquot of water and then lyophilized to yield a solid (Compound 2). 94.02 mg of solid Compound 2 (M. W. 505.4) were collected (Yield: 89.0 %). The collected Compound 2 was positive both to resorcinol-HCI andTBA reactions. |
Tags: 36791-04-5 synthesis path| 36791-04-5 SDS| 36791-04-5 COA| 36791-04-5 purity| 36791-04-5 application| 36791-04-5 NMR| 36791-04-5 COA| 36791-04-5 structure
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P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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