Home Cart 0 Sign in  

[ CAS No. 374706-07-7 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 374706-07-7
Chemical Structure| 374706-07-7
Structure of 374706-07-7 * Storage: {[proInfo.prStorage]}

Quality Control of [ 374706-07-7 ]

Related Doc. of [ 374706-07-7 ]

SDS
Alternatived Products of [ 374706-07-7 ]
Alternatived Products of [ 374706-07-7 ]

Product Details of [ 374706-07-7 ]

CAS No. :374706-07-7 MDL No. :MFCD01548979
Formula : C10H10O2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :162.19 g/mol Pubchem ID :45086222
Synonyms :

Safety of [ 374706-07-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 374706-07-7 ]

  • Upstream synthesis route of [ 374706-07-7 ]
  • Downstream synthetic route of [ 374706-07-7 ]

[ 374706-07-7 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 97674-02-7 ]
  • [ 189035-22-1 ]
  • [ 374706-07-7 ]
YieldReaction ConditionsOperation in experiment
73.7% With bis-triphenylphosphine-palladium(II) chloride In toluene at 90℃; for 16 h; The title compound was prepared according to procedures reported in the literature and known by persons skill in the art, using 6-bromo-2,3-dihydro-1-benzofuran (1 g, 5.03 mmol) as starting material. In a preferred method, 6-bromo-2,3-dihydro-1-benzofuran (1 g, 5.03 mmol) in toluene (10 mL) was degassed for 30 min. To this solution, 1-ethoxyvinyl tributyltin (2.012 g, 5.53 mmol) and bis(triphenylphosphine)palladium dichloride (0.35 g, 0.50 mmol) were added at rt and stirred for 16 hours at 90 °C. The reaction mixture was cooled to rt and filtered through celite. After evaporation of the solvent, 6 N HCl solution in water (10 mL) was added and the mixture was stirred for 1 hour at rt. It was concentrated and neutralized with sat. NaHCO3. The desired product was extracted with DCM (50 mL), dried over Na2SO4 and concentrated. The crude product was purified by flash chromatography to give the title compound. Yield: 73.7percent (0.6 g, pale yellow solid). 1H NMR (400 MHz, DMSO-d6): δ 7.48 (d, J = 7.64 Hz, 1H), 7.37-7.35 (d, J = 7.68 Hz, 1H), 7.26 (s, 1H), 4.58 (t, J = 8.76 Hz, 2H), 3.24 (t, J = 8.76 Hz, 2H), 2.53 (s, 3H). LCMS: (Method A) 163.2 (M+H), Rt. 3.01 min, 97.60percent (Max).
Reference: [1] Patent: WO2017/144635, 2017, A1, . Location in patent: Page/Page column 32; 33
  • 2
  • [ 108-24-7 ]
  • [ 374706-07-7 ]
Reference: [1] Patent: WO2006/137796, 2006, A1, . Location in patent: Page/Page column 86
  • 3
  • [ 189035-22-1 ]
  • [ 374706-07-7 ]
Reference: [1] Patent: WO2006/137796, 2006, A1,
Historical Records

Related Functional Groups of
[ 374706-07-7 ]

Ketones

Chemical Structure| 170730-06-0

[ 170730-06-0 ]

1-(2,3-Dihydro-7-benzofuranyl)ethanone

Similarity: 0.98

Chemical Structure| 90843-31-5

[ 90843-31-5 ]

5-Acetyl-2,3-dihydrobenzo[b]furan

Similarity: 0.98

Chemical Structure| 1048917-42-5

[ 1048917-42-5 ]

1-(5-Methyl-2-propoxyphenyl)ethanone

Similarity: 0.95

Chemical Structure| 2142-67-8

[ 2142-67-8 ]

1-(2-Ethoxyphenyl)ethanone

Similarity: 0.95

Chemical Structure| 19278-82-1

[ 19278-82-1 ]

5-Hydroxybenzofuran-3(2H)-one

Similarity: 0.94

Related Parent Nucleus of
[ 374706-07-7 ]

Benzofurans

Chemical Structure| 170730-06-0

[ 170730-06-0 ]

1-(2,3-Dihydro-7-benzofuranyl)ethanone

Similarity: 0.98

Chemical Structure| 90843-31-5

[ 90843-31-5 ]

5-Acetyl-2,3-dihydrobenzo[b]furan

Similarity: 0.98

Chemical Structure| 55745-96-5

[ 55745-96-5 ]

2,3-Dihydrobenzofuran-6-carbaldehyde

Similarity: 0.95

Chemical Structure| 99385-88-3

[ 99385-88-3 ]

5-Hydroxy-2,3-dihydrobenzofuran-6-carbaldehyde

Similarity: 0.95

Chemical Structure| 19278-82-1

[ 19278-82-1 ]

5-Hydroxybenzofuran-3(2H)-one

Similarity: 0.94