Alternatived Products of [ 37676-90-7 ]
Product Details of [ 37676-90-7 ]
CAS No. : | 37676-90-7 |
MDL No. : | MFCD18806719 |
Formula : |
C7H10O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
126.15
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Pubchem ID : | - |
Synonyms : |
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Application In Synthesis of [ 37676-90-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 37676-90-7 ]
- 1
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[ 37676-90-7 ]
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[ 37676-95-2 ]
Yield | Reaction Conditions | Operation in experiment |
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With tetrachloromethane; bromine |
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- 2
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[ 408314-33-0 ]
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[ 37676-90-7 ]
Yield | Reaction Conditions | Operation in experiment |
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With potassium hydroxide; toluene |
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- 3
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[ 408314-33-0 ]
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[ 37676-90-7 ]
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1-hydroxy-3,3-dimethyl-cyclobutanecarboxylic acid methyl ester
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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With potassium hydroxide; toluene Behandeln des Reaktionsprodukts mit Diazomethan in Aether; |
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- 4
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[ 19251-73-1 ]
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[ 37676-90-7 ]
Yield | Reaction Conditions | Operation in experiment |
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(i) TsOMe, (ii) aq. KOH; Multistep reaction; |
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- 5
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[ 64-17-5 ]
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[ 37676-90-7 ]
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[ 37676-92-9 ]
- 6
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[ 37676-90-7 ]
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[ 503-53-7 ]
Yield | Reaction Conditions | Operation in experiment |
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With hydrogenchloride |
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- 7
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[ 37676-90-7 ]
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[ 75017-17-3 ]
Yield | Reaction Conditions | Operation in experiment |
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With lithium aluminium tetrahydride; hydrogen Multistep reaction; |
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- 8
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[ 20104-44-3 ]
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[ 37676-90-7 ]
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide; methyl iodide 1.) 80 deg C, 4 h, 2.) 80 deg C, 16 h; Yield given. Multistep reaction. Yields of byproduct given; |
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- 9
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[ 20104-44-3 ]
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[ 37676-90-7 ]
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[ 75017-16-2 ]
Yield | Reaction Conditions | Operation in experiment |
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Yield given. Multistep reaction. Yields of byproduct given; |
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Yield | Reaction Conditions | Operation in experiment |
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Rk. m. sd. wss. HCl (15 Stdn.) -> 4-Carboxy-2.2-dimethyl-butanal; |
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Yield | Reaction Conditions | Operation in experiment |
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Beh. v. 1-Methoxycarbonyl-2-trimethylamino-3.3-dimethyl-cyclobutantosylat m. wss. KOH Lsg.; |
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(yield)81percent; |
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- 12
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[ 37676-90-7 ]
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[ 76207-24-4 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: 1.) H2, 2.) LiAlH4
2: pyridine / 0 °C |
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- 13
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[ 37676-90-7 ]
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[ 75017-23-1 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: 1.) H2, 2.) LiAlH4
2: pyridine / 0 °C
3: LiCl / hexamethylphosphoric acid triamide / Ambient temperature |
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- 14
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[ 37676-90-7 ]
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[ 71385-29-0 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 4 steps
4: aq. HCl |
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- 15
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[ 37676-90-7 ]
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[ 93305-26-1 ]
- 16
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[ 37676-90-7 ]
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3,3-Dimethyl-2-(propylamino)-cyclobutancarbonsaeure-aethylester
[ No CAS ]
- 17
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[ 37676-90-7 ]
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[ 92329-72-1 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
2: (i), (ii) /BRN= 605303/, Py |
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- 18
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tert-butyl 2-(N-pyrrolidino)-3,3-dimethylcyclobutane-1-carboxylate
[ No CAS ]
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[ 37676-90-7 ]
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[ 1373621-73-8 ]
Yield | Reaction Conditions | Operation in experiment |
1: 69%
2: 6% |
Stage #1: tert-butyl 2-(N-pyrrolidino)-3,3-dimethylcyclobutane-1-carboxylate With methyl p-toluene sulfonate In acetonitrile at 20℃;
Stage #2: With potassium hydroxide In water; acetonitrile Reflux;
Stage #3: With hydrogenchloride In water; acetonitrile Cooling; |
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1: 49%
2: 45% |
Stage #1: tert-butyl 2-(N-pyrrolidino)-3,3-dimethylcyclobutane-1-carboxylate With methyl iodide In acetonitrile at 20℃; for 14h;
Stage #2: With potassium <i>tert</i>-butylate In diethyl ether for 4h; Reflux;
Stage #3: With hydrogenchloride In diethyl ether; water Cooling; |
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Reference:
[1]Location in patent: scheme or table
Charnay-Pouget, Florence; Frank, Michael; Baltaze, Jean-Pierre; Pereira, Elisabeth; Aitken, David J.
[ARKIVOC, 2012, vol. 2012, # 5, p. 80 - 93]
[2]Location in patent: experimental part
Charnay-Pouget, Florence; Frank, Michael; Baltaze, Jean-Pierre; Pereira, Elisabeth; Aitken, David J.
[ARKIVOC, 2012, vol. 2012, # 5, p. 80 - 93]
- 19
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[ 37676-90-7 ]
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tert-butyl cis-2-[(S)-N-α-methylbenzyl-N-benzylamino]-3,3-dimethylcyclobutane-1-carboxylate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1.1: sulfuric acid / dichloromethane / -78 - -25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C
2.2: 20 °C / Cooling |
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- 20
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[ 37676-90-7 ]
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tert-butyl trans-2-[(S)-N-α-methylbenzyl-N-benzylamino]-3,3-dimethylcyclobutane-1-carboxylate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1.1: sulfuric acid / dichloromethane / -78 - -25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C
2.2: 20 °C / Cooling |
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- 21
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[ 37676-90-7 ]
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trans-2-amino-3,3-dimethylcyclobutane-1-carboxylic acid
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1.1: sulfuric acid / dichloromethane / -78 - -25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C
2.2: 20 °C / Cooling
3.1: 20 % Pd(OH)2/C; hydrogen; acetic acid / 20 h / 60 °C / 2280.15 Torr
3.2: 24 h / 20 °C
3.3: Dowex 50X8 20-50 mesh |
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- 22
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[ 37676-90-7 ]
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tert-butyl-2-(N,N-dibenzylamino)-3,3-dimethylcyclobutane-1-carboxylate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1.1: sulfuric acid / dichloromethane / -78 - -25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C
2.2: 20 °C |
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- 23
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[ 37676-90-7 ]
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tert-butyl (+/-)-cis-2-(N,N-dibenzylamino)-3,3-dimethylcyclobutane-1-carboxylate
[ No CAS ]
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tert-butyl (+/-)-trans-2-(N,N-dibenzylamino)-3,3-dimethylcyclobutane-1-carboxylate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1.1: sulfuric acid / dichloromethane / -78 - -25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C
2.2: 20 °C |
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- 24
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[ 37676-90-7 ]
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tert-butyl (+/-)-trans-2-(N,N-dibenzylamino)-3,3-dimethylcyclobutane-1-carboxylate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1.1: sulfuric acid / dichloromethane / -78 - -25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C
2.2: 20 °C
3.1: sodium hexamethyldisilazane; <i>tert</i>-butyl alcohol / tetrahydrofuran / 120 h |
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- 25
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[ 37676-90-7 ]
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[ 115-11-7 ]
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[ 1373621-73-8 ]
Yield | Reaction Conditions | Operation in experiment |
97% |
With sulfuric acid In dichloromethane at -78 - -25℃; |
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