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[ CAS No. 3768-18-1 ]

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Chemical Structure| 3768-18-1
Chemical Structure| 3768-18-1
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Product Details of [ 3768-18-1 ]

CAS No. :3768-18-1 MDL No. :MFCD00006540
Formula : C11H15N3O6 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :285.25 g/mol Pubchem ID :107461
Synonyms :

Safety of [ 3768-18-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 3768-18-1 ]

  • Upstream synthesis route of [ 3768-18-1 ]
  • Downstream synthetic route of [ 3768-18-1 ]

[ 3768-18-1 ] Synthesis Path-Upstream   1~8

  • 1
  • [ 3768-18-1 ]
  • [ 14631-20-0 ]
  • [ 120885-66-7 ]
  • [ 126430-20-4 ]
Reference: [1] Journal of Organic Chemistry, 1992, vol. 57, # 12, p. 3473 - 3478
  • 2
  • [ 108-24-7 ]
  • [ 65-46-3 ]
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YieldReaction ConditionsOperation in experiment
96% for 3 h; Reflux In a 500 mL three-necked flask was added 50.0 g of Compound 3 powder and 250 mL of acetonitrile and 25 mL of acetic anhydride, stirred and refluxed for 3 h, cooled to room temperature and filtered with suction. The solid was washed with acetonitrile twice and the filter cake was dried to give 56.3 g of compound 4 with a yield of 96.0 percent.
95% for 0.0111111 h; Microwave radiation To a solution of cytidine (1.22 g, 5.00 mmol) in DMF(40 mL) is added acetic anhydride (0.94 mL, 10.00 mmol). The solution is treated with microwave radiation (Panasonic, 1000 Watts) at full power for 40 seconds. The solution is concentrated in vacuo and the residue is co-evaporated with methanol (2.x.20 mL) to give 4-N-acetyl-cytidine (1.43 g, 95.0percent) as a white powder. MS (FAB):m/z 286 (MH+).
87% for 24 h; Cytidine (100.Og, 0.41 mol) was dissolved in DMF (500 ml), acetic anhydride (42.5 ml, 45.9 g, 0.45 mol) was added and the whole was left for 24 h. Solvent was evaporated, the residue boiled with methanol (40 ml) and cooled. Crystals were filtered and dried to furnish Λ^-acetylcytidine (102 g, 87.0percent).
Reference: [1] Tetrahedron Letters, 1997, vol. 38, # 41, p. 7253 - 7254
[2] Patent: CN107033205, 2017, A, . Location in patent: Paragraph 0033; 0034; 0035; 0036
[3] Patent: US6822089, 2004, B1, . Location in patent: Page column 13
[4] Nucleosides and Nucleotides, 1997, vol. 16, # 4, p. 469 - 474
[5] Patent: WO2010/108140, 2010, A1, . Location in patent: Page/Page column 138
[6] Journal of Organic Chemistry, 2002, vol. 67, # 26, p. 9331 - 9339
[7] Journal of the American Chemical Society, 1983, vol. 105, # 12, p. 4059 - 4065
[8] Phosphorus, Sulfur and Silicon and Related Elements, 2002, vol. 177, # 6-7, p. 1783 - 1786
[9] Tetrahedron Letters, 1998, vol. 39, # 14, p. 1897 - 1900
  • 3
  • [ 65-46-3 ]
  • [ 3768-18-1 ]
Reference: [1] Tetrahedron Letters, 1991, vol. 32, # 24, p. 2817 - 2820
[2] Bioscience, Biotechnology and Biochemistry, 2000, vol. 64, # 2, p. 363 - 368
[3] Tetrahedron Letters, 1989, vol. 30, # 1, p. 71 - 74
[4] Patent: US5808039, 1998, A,
  • 4
  • [ 5040-18-6 ]
  • [ 3768-18-1 ]
Reference: [1] Bioscience, Biotechnology and Biochemistry, 2000, vol. 64, # 2, p. 363 - 368
  • 5
  • [ 64-19-7 ]
  • [ 65-46-3 ]
  • [ 3768-18-1 ]
Reference: [1] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 7, p. 2061 - 2064
  • 6
  • [ 70740-24-8 ]
  • [ 65-46-3 ]
  • [ 3768-18-1 ]
Reference: [1] Tetrahedron Letters, 2006, vol. 47, # 25, p. 4201 - 4203
  • 7
  • [ 75-36-5 ]
  • [ 51432-41-8 ]
  • [ 3768-18-1 ]
Reference: [1] Tetrahedron Letters, 1989, vol. 30, # 1, p. 71 - 74
  • 8
  • [ 3768-18-1 ]
  • [ 121058-88-6 ]
Reference: [1] Tetrahedron Letters, 1995, vol. 36, # 49, p. 8929 - 8932
[2] Tetrahedron Letters, 1989, vol. 30, # 1, p. 71 - 74
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