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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
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CAS No. : | 380449-51-4 | MDL No. : | MFCD32710101 |
Formula : | C24H30Cl2FN3O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 498.42 | Pubchem ID : | - |
Synonyms : |
Melphalan flufenamide
|
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P201-P391-P202-P261-P264-P270-P272-P280-P301+P310+P330-P302+P352-P308+P313-P333+P313-P405-P501 | UN#: | 2811 |
Hazard Statements: | H300-H316-H317-H340-H350-H361 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
66% | In n-heptane; dichloromethane for 0.166667h; | 4.1 4.1: Preparation of melflufen ethanesulfonic acid salt (ethanesulfonic acid; ethyl (0176) (2S)-2-[[(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3- (0177) (4-fluorophenyl)propanoate) Melflufen freebase (120 mg, 0.24 mmol) was dissolved in DCM (1 mL) and ethansulfonic acid (26.4 mg, 0.24 mmol) in DCM (200 pL) was added. Heptane (500 pL) was added and the mixture was stirred for 10 minutes before being concentrated in vacuo to furnish a white solid. The white solid was triturated with heptane (1 mL) and dried in vacuo to give the title compound as a white solid. Yield 97 mg (66%). (0180) NMR reveals salt formation of 1 : 1 (mol). NMR (400 MHz, DMSO-d6) d 8.94 (d, J = 7.6 Hz, 1H), 8.12 - 7.95 (m, 2H), 7.35 - 7.21 (m, 2H), 7.19 - 7.04 (m, 4H), 6.77 - 6.64 (m, 2H), 4.61 - 4.51 (m, 1H), 4.07 (q, J = 7.1 Hz, 2H), 3.93 (s, 1H), 3.71 (s, 8H), 3.14 - 2.92 (m, 3H), 2.80 (dd, J = 14.3, 8.2 Hz, 1H), 2.38 (q, J = 7.4 Hz, 2H), 1.13 (t, J = 7.1 Hz, 3H), 1.06 (t, J = 7.4 Hz, 3H). |