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Chemical Structure| 3895-92-9 Chemical Structure| 3895-92-9

Structure of Chelerythrine Chloride
CAS No.: 3895-92-9

Chemical Structure| 3895-92-9

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Chelerythrine chloride acts as a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Additionally, it inhibits the binding of the Bcl-XL-Bak BH3 peptide with an IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces both apoptosis and autophagy.

Synonyms: Chelerythrine (chloride); NSC 646662; Broussonpapyrine chloride

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Product Details of Chelerythrine Chloride

CAS No. :3895-92-9
Formula : C21H18ClNO4
M.W : 383.82
SMILES Code : C[N+]1=CC2=C(OC)C(OC)=CC=C2C3=C1C4=CC5=C(OCO5)C=C4C=C3.[Cl-]
Synonyms :
Chelerythrine (chloride); NSC 646662; Broussonpapyrine chloride
MDL No. :MFCD00060717
InChI Key :WEEFNMFMNMASJY-UHFFFAOYSA-M
Pubchem ID :72311

Safety of Chelerythrine Chloride

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302+H312+H332-H315-H319-H335
Precautionary Statements:P261-P280-P305+P351+P338

Related Pathways of Chelerythrine Chloride

epigenetics
GPCR

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Human erythrocytes 1-10 µM 2 hours To investigate whether chelerythrine can inhibit costunolide-induced eryptosis and cell shrinkage. Results showed that chelerythrine was able to partially inhibit costunolide-induced phosphatidylserine exposure and cell shrinkage. PMC7527323

Protocol

Bio Calculators
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2.61mL

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0.26mL

13.03mL

2.61mL

1.30mL

26.05mL

5.21mL

2.61mL

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