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CAS No. : | 399-00-8 | MDL No. : | MFCD06739493 |
Formula : | C7H4BrFO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | QKTZGVUIYFBODQ-UHFFFAOYSA-N |
M.W : | 219.01 | Pubchem ID : | 7172128 |
Synonyms : |
|
Num. heavy atoms : | 11 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.0 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 3.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 41.51 |
TPSA : | 37.3 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.95 cm/s |
Log Po/w (iLOGP) : | 1.38 |
Log Po/w (XLOGP3) : | 2.37 |
Log Po/w (WLOGP) : | 2.53 |
Log Po/w (MLOGP) : | 1.97 |
Log Po/w (SILICOS-IT) : | 2.6 |
Consensus Log Po/w : | 2.17 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -3.03 |
Solubility : | 0.205 mg/ml ; 0.000936 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.79 |
Solubility : | 0.352 mg/ml ; 0.00161 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -2.91 |
Solubility : | 0.269 mg/ml ; 0.00123 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.49 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With bromine In chloroform at 20℃; for 40 h; | Bromine (14.1 g, 88.3 mmol) in chloroform (25 mL) was added over a 10 minute period to a round bottom flask containing 4-fluoro-2-hydroxybenzaldehyde (13.6 g, 97.1 mmol) in chloroform (68 mL). This mixture was stirred at room temperature for 16 hours, and additional bromine (14.1 g) was added. The mixture was stirred for an additional 24 hours at room temperature. The mixture was then washed with 30percent aqueous sodium thiosulfate solution (2 X) to discharge the color, water, and then dried over sodium sulfate. The organics were concentrated under reduced pressure to give 5-bromo-4-fluoro-2- hydroxybenzaldehyde (21.3 g, 100percent). |
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