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[ CAS No. 405-85-6 ] {[proInfo.proName]}

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Chemical Structure| 405-85-6
Chemical Structure| 405-85-6
Structure of 405-85-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 405-85-6 ]

CAS No. :405-85-6 MDL No. :MFCD05663826
Formula : C14H11FO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :246.23 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 405-85-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 405-85-6 ]

[ 405-85-6 ] Synthesis Path-Downstream   1~12

  • 1
  • [ 456-42-8 ]
  • [ 99-96-7 ]
  • [ 405-85-6 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide
YieldReaction ConditionsOperation in experiment
at 20℃;
  • 3
  • [ 454473-78-0 ]
  • [ 405-85-6 ]
YieldReaction ConditionsOperation in experiment
79% Stage #1: methyl 4-[(3-fluorobenzyl)oxy]benzoate With water; sodium hydroxide In methanol at 75℃; for 2h; Stage #2: With hydrogenchloride In water
With water; sodium hydroxide In ethanol for 2h; Reflux;
  • 4
  • [ 99-76-3 ]
  • [ 405-85-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetone / 5 h / 65 - 80 °C 2.1: sodium hydroxide; water / methanol / 2 h / 75 °C 2.2: pH 5
Multi-step reaction with 2 steps 1: potassium carbonate / acetone / 5 h / 80 °C 2: water; sodium hydroxide / ethanol / 2 h / Reflux
  • 5
  • [ 456-41-7 ]
  • [ 405-85-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetone / 5 h / 65 - 80 °C 2.1: sodium hydroxide; water / methanol / 2 h / 75 °C 2.2: pH 5
Multi-step reaction with 2 steps 1: potassium carbonate / acetone / 5 h / 80 °C 2: water; sodium hydroxide / ethanol / 2 h / Reflux
  • 7
  • [ 405-85-6 ]
  • N-(3-(1H-benzo[d]imidazol-2-yl)-4-methylphenylcarbamothioyl)-4-(3-fluorobenzyloxy)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: pyridine; thionyl chloride / toluene / 6 h / 72 °C 2.1: acetonitrile / 5 h / 80 °C 2.2: 10 h / 80 °C
  • 8
  • [ 405-85-6 ]
  • N-(3-(1H-benzo[d]imidazol-2-yl)-4-methylphenylcarbamoyl)-4-(3-fluorobenzyloxy)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: pyridine; thionyl chloride / toluene / 6 h / 72 °C 2.1: acetonitrile / 5 h / 80 °C 2.2: 10 h / 80 °C 3.1: sodium carbonate; dihydrogen peroxide / acetone / 20 °C
  • 9
  • [ 1004517-07-0 ]
  • [ 405-85-6 ]
  • C29H21ClFN3O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃;
  • 10
  • [ 405-85-6 ]
  • 1-(2-aminoethyl)-3-((4-methoxybenzyl)oxy)-2-methylpyridin-4(1H)-one [ No CAS ]
  • N-(2-(2-methyl-3-hydroxy-1(4H)-4-oxopyridinyl)ethyl)-4-(3-fluorobenzyloxy)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: dicyclohexyl-carbodiimide; 2-mercaptothiazoline; dmap / dichloromethane / 24 h / 20 °C 1.2: 24 h / 20 °C 2.1: boron trichloride / dichloromethane / 12 h / -78 - 20 °C / Inert atmosphere
Multi-step reaction with 2 steps 1.1: dicyclohexyl-carbodiimide; dmap; 2-mercaptothiazoline / dichloromethane / 24 h / 20 °C 1.2: 24 h / 20 °C 2.1: boron trichloride / dichloromethane / 12 h / -78 - 20 °C
  • 11
  • [ 405-85-6 ]
  • 1-(2-aminoethyl)-3-((4-methoxybenzyl)oxy)-2-methylpyridin-4(1H)-one [ No CAS ]
  • C30H29FN2O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% Stage #1: 4-(3-fluorobenzyloxy)benzoic acid With dmap; 2-mercaptothiazoline; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Stage #2: 1-(2-aminoethyl)-3-((4-methoxybenzyl)oxy)-2-methylpyridin-4(1H)-one In dichloromethane at 20℃; for 24h; 12 Add 3-fluorobenzyloxybenzoic acid (0.246g, 1mmol), dichloromethane (10mL), and then add dicyclohexylcarbodiimide (0.226g, 1.1mmol), 2-mercaptothiazole in a 100mL single-mouth flask Pholine (0.130g, 1.1mmol), 4-dimethylaminopyridine (5mg, 0.04mmol), react at room temperature for 24h, after the reaction is over, filter, and concentrate the filtrate for use. Add 1-(2-aminoethyl)-2-methyl-3-methoxypyridin-4-one (0.182g, 1mmol) and dichloromethane (10mL) into a 100mL single-neck flask, and add the above filtrate dropwise, React at room temperature for 24 hours. After the reaction is completed, the reaction solution is concentrated and purified by silica gel column chromatography (dichloromethane: methanol = 100:1-20:1 gradient elution) to obtain a pale yellow solid (0.361 g) with a yield of 70%.
Stage #1: 4-(3-fluorobenzyloxy)benzoic acid With dmap; 2-mercaptothiazoline; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Stage #2: 1-(2-aminoethyl)-3-((4-methoxybenzyl)oxy)-2-methylpyridin-4(1H)-one In dichloromethane at 20℃; for 24h;
  • 12
  • [ 456-41-7 ]
  • [ 99-96-7 ]
  • [ 405-85-6 ]
YieldReaction ConditionsOperation in experiment
97% With potassium hydroxide In ethanol; water for 8h; Reflux; 12 Add 4-hydroxybenzoic acid (1.38g, 10mmol), potassium hydroxide (1.12g, 20mmol), ethanol (20mL), water (10mL) into a 100mL single-mouth flask, and add 3-fluorobenzyl bromide (3.78g, 20mmol) dropwise ), reflux and react for 8h. After the raw materials are completely reacted, add water (30mL), adjust the pH to 2.0 with concentrated hydrochloric acid, precipitate a solid, filter, wash with water, wash with n-hexane, and dry to obtain solid 3-fluorobenzyloxybenzoic acid (2.38g ), the yield is 97%.
With potassium hydroxide In ethanol; water Reflux;
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