[ CAS No. 41153-30-4 ]

Name: 41153-30-4|Boc-Phe(4-F)-OH|98%
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Product Details of [ 41153-30-4 ]

CAS No. :	41153-30-4	MDL No. :	MFCD00079672
Formula :	C₁₄H₁₈FNO₄	Boiling Point :	431.2°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	-
M.W :	283.30 g/mol	Pubchem ID :	7020910
Synonyms :

Safety of [ 41153-30-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 41153-30-4 ]

Upstream synthesis route of [ 41153-30-4 ]
Downstream synthetic route of [ 41153-30-4 ]

[ 41153-30-4 ] Synthesis Path-Upstream 1~3

1
[ 24424-99-5 ]
[ 1132-68-9 ]
[ 41153-30-4 ]

Yield	Reaction Conditions	Operation in experiment
72.5%	With sodium hydroxide In 1,4-dioxane; water at 20℃; for 6 h; Cooling with ice	A solution of L-4F-Phe-COOH 1.97 g (10 mmol) in a mixture of dioxane (20 mL), water (20 mL) and 1 M NaOH (10 mL) was stirred and cooled in an ice-water bath. Ditert-butylpyrocarbonate 2.4 g (11 mmol) was added and stirring was continued at room temperature for 6 h. Then the solution was concentrated in vacuum to about 15—20 mL, cooled in an ice water bath, covered with a layer of ethyl acetate (about 30 mL) and a dilute solution of KHSO4 was added to acidify (pH 2—3). The aqueous phase was extracted with ethyl acetate and this operation was done three times. The ethyl acetate extracts were collected and dried over anhydrous Na2SO4 and evaporated in a vacuum. The pure material was obtained as a waxy solid.Yield: 2.115 g (7.25 mmol, 72.5percent)1H NMR (DMSO-d6, 400 MHz, ppm): 12.60 [s, 1H COOH], 7.29-7.25 & 7.11-7.07 [m, 4H, Aromatic protons], 4.10-3.00 [m, 1H, CaH 4F Phe], 3.03-2.77 [m, 2H, CI3H4F Phe], 1.33 [s, 9H, Boc].MALDI-TOF (matrix: a-cyano-4-hydroxy cinnamic acid (CHCA)) :mlz= [M+H] + 284.12 (calculated), 284.29 (observed), [M+Na]+ 306.11 (calculated), 306.25 (observed).

Reference： [1] Chemical Communications, 2014, vol. 50, # 76, p. 11154 - 11157
[2] Patent: WO2017/42805, 2017, A1, . Location in patent: Page/Page column 24; 25
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 2090 - 2099
[4] Bioorganic and Medicinal Chemistry, 1996, vol. 4, # 10, p. 1733 - 1745

2
[ 24424-99-5 ]
[ 51-65-0 ]
[ 41153-30-4 ]

Reference： [1] Patent: US5753652, 1998, A,

3
[ 58632-95-4 ]
[ 1132-68-9 ]
[ 41153-30-4 ]

Reference： [1] Chemical and Pharmaceutical Bulletin, 1989, vol. 37, # 3, p. 826 - 828

[ 41153-30-4 ] Synthesis Path-Downstream 1~25

1
[ 6638-79-5 ]
[ 41153-30-4 ]
[ 135545-01-6 ]

Yield	Reaction Conditions	Operation in experiment
70%	With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile; at 20℃;	General procedure: To a solution of appropriate amino protected carboxylic acidderivative (1 eq.) dissolved in a mixture of CH2Cl2 and CH3CN (1:1, 3.7 mL/mmol of carboxylic acid), EDC (1.3 eq.), HOBt (1.3 eq.), NMM (6.5 eq.) and HN(Me)OMe*HCl (2.1 eq.) were added. The mixture was stirred at room temperature over 24-72 h and then evaporated.The resulting crude product was dissolved in CH2Cl2, washed three times with saturated NaHCO3 solution, three times with 1 M HCl and once with brine. Organic layer was dried over MgSO4,filtered and concentrated in vacuo. Purification via flash chromatography was performed. 4.2.5 tert-Butyl N-[(1S)-1-[(4-fluorophenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate (9a) According to general method 1, 9a was obtained as a colorless oil (0.810 g, 70%). 1H NMR (CDCl3, 300 MHz), delta (ppm): 7.18-7.09 (m, 2H); 7.02-6.90 (m, 2H); 5.28-5.17 (d, J = 12.1 Hz, 1H), 5.00-4.82 (unresolved X part of ABX system, m, 1H); 3.67 (s, 3H); 3.16 (s, 3H); 2.87 [AB part of ABX system (dd, J = 12.2 and 6.3 Hz, 1H) and (dd, J = 12.1 and 6.6 Hz, 1H), Deltanu = 60 Hz]; 1.38 (s, 9H). 13C NMR (CDCl3, 75 MHz), delta (ppm): 172.0, 163.5, 160.2 (JC-F = 234 Hz); 155.1, 132.3, 131.0, 130.9, 115.3, 115.0, 79.6, 61.6, 51.5, 38.1, 32.0, 28.3. MS (ESI+): m/z = 327.1 [M,H]+ found; C16H24FN2O4 calculated m/z = 327.2 [M,H]+.

Reference： [1]European Journal of Medicinal Chemistry,2015,vol. 106,p. 15 - 25
[2]Bulletin des Societes Chimiques Belges,1991,vol. 100,p. 381 - 399

2
[ 5382-17-2 ]
[ 41153-30-4 ]
[ 186431-68-5 ]

Yield	Reaction Conditions	Operation in experiment
	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20℃; for 16.0h;	To a stirred solution OF BOC-3- (4-FLUOROPHENYL)- (S)-ALANINE (LO. OG, 35. 3MMOL), <strong>[5382-17-2]4-hydroxypiperidine hydrochloride</strong> (5. 1G, 37. 1MMOL) and HOBt (7.2g, 52. 9MMOL) in DMF (lOOmL), was added DIPEA (12. 3mL, 70. 6MMOL) and after 5MIN, EDCI (7.4g, 38. 8MMOL) and the reaction stirred at rt for 16H. The solvent was removed in vacuo and the residue partitioned between water (150ML) and ethyl acetate (2 x 150ML). The combined organic fractions were washed with sodium hydroxide solution (2M, 50ML), hydrochloric acid (2N, 50ML), dried (MGS04) and concentrated in vacuo. The product was chromatographed on silica gel eluting with ethyl acetate to give the title compound as a white solid. m/z (ES+) = 367 [M+ H] + ; RT = 3.28min.

Reference： [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 2934 - 2938
[2]Patent: WO2004/104001,2004,A2 .Location in patent: Page 36

3
[ 3978-80-1 ]
[ 61925-78-8 ]
[ 41153-30-4 ]
S-p-MeBzl-N^α-Boc-D-Pen Merrifield [ No CAS ]
Tyr-D-Cys-p-FPhe-D-Pen-OH [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1992,vol. 35,p. 1535 - 1541

4
[ 13139-15-6 ]
[ 140-10-3 ]
[ 55533-24-9 ]
[ 41153-30-4 ]
Boc-Arg [ No CAS ]
(S)-2-((S)-3-(4-Amino-phenyl)-2-{(S)-3-(4-fluoro-phenyl)-2-[(E)-(3-phenyl-acryloyl)amino]-propionylamino}-propionylamino)-4-methyl-pentanoic acid ((S)-1-carbamoyl-4-guanidino-butyl)-amide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 4879 - 4887

5
[ 13139-15-6 ]
[ 140-10-3 ]
[ 82732-07-8 ]
[ 41153-30-4 ]
Boc-Arg [ No CAS ]
(S)-2-((S)-2-{(S)-3-(4-Fluoro-phenyl)-2-[(E)-(3-phenyl-acryloyl)amino]-propionylamino}-4-phenyl-butyrylamino)-4-methyl-pentanoic acid ((S)-1-carbamoyl-4-guanidino-butyl)-amide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 4879 - 4887

6
[ 13139-15-6 ]
[ 3262-72-4 ]
[ 55447-00-2 ]
[ 41153-30-4 ]
Boc-Arg [ No CAS ]
(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-fluoro-phenyl)-propionylamino]-3-naphthalen-1-yl-propionylamino}-4-methyl-pentanoic acid ((S)-1-carbamoyl-4-guanidino-butyl)-amide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 4879 - 4887

7
[ 1477-49-2 ]
[ 13139-15-6 ]
[ 59543-09-8 ]
[ 41153-30-4 ]
Boc-Arg [ No CAS ]
(S)-2-[(S)-2-{(S)-3-(4-Fluoro-phenyl)-2-[2-(1H-indol-3-yl)-2-oxo-acetylamino]-propionylamino}-3-(4-guanidino-phenyl)-propionylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-4-guanidino-butyl)-amide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 4879 - 4887

8
[ 41153-30-4 ]
[ 1117-97-1 ]
[ 135545-01-6 ]

Yield	Reaction Conditions	Operation in experiment
69.4%	With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 0 - 25℃; for 16h;Inert atmosphere;	[0622] to a solution of n-methoxymethanamine (1.89 g 19.42 mmol), compound 58a (5.0 g, 17.65 mmol), hobt (2.38 g, 17.65 mmol) and nmm (52.95 mmol, 5.8 ml) in cHCl3 (100 ml) was degassed and purged with n2 for 3 times at 0 C, then edci (5.1 g, 26.48 mmol) was added in portions. The mixture was stirred at 25 C for 16 hrs under N2 atmosphere. The reaction mixture was washed with H2O (100 ml). The organic layers were washed with lmol/l hcl (100 ml x 2), saturated NaHCO3 (100 ml x 2) and saturated brine (100ml), dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by flash silica gel chromatography (isco;80 g sepaflash silica flash column, eluent of 0 ~ 30% ethyl acetate/petroleum ether gradient 40ml/min) to afford compound 58b (4.00 g, yield 69.4%) as white solid. 1H NMR (400mhz,CDCl3) delta 7.11 (dd, 7=5.6, 8.3 hz, 2h), 6.94 (t, 7=8.7 hz, 2h), 5.18 (br d, 7=7.9 hz, 1h), 4.98 - 4.80 (m, 1h), 4.13- 4.07 (m, 2h), 3.72 -3.64 (m, 4h), 3.14 (s, 3h), 3.08 - 2.94 (m, 1h), 2.91 - 2.70 (m, 1h), 2.02 (s, 2h), 1.78 (br s, 1h), 1.37 (s, 10h), 1.28 - 1.20 (m, 3h).

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 5176 - 5181
[2]Patent: WO2018/64119,2018,A1 .Location in patent: Paragraph 0622

9
[ 151-63-3 ]
[ 41153-30-4 ]
[1-(cyanomethyl-carbamoyl)-2-(4-fluoro-phenyl)-ethyl]-carbamic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 7688 - 7707

10
[ 41153-30-4 ]
[ 85068-29-7 ]
[1-(3,5-bis-trifluoromethyl-benzylcarbamoyl)-2-(4-fluoro-phenyl)-ethyl]-carbamic acid tert-butyl ester [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 3735 - 3739

11
1-(6-phenylhexyl)-4-piperidone [ No CAS ]
Rink-isonitrile resin [ No CAS ]
[ 107-10-8 ]
[ 41153-30-4 ]
(S)-3-(4-Fluoro-benzyl)-9-(6-phenyl-hexyl)-1-propyl-1,4,9-triaza-spiro[5.5]undecane-2,5-dione [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 4145 - 4152

12
[ 41153-30-4 ]
[ 135544-90-0 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 5176 - 5181
[2]Bulletin des Societes Chimiques Belges,1991,vol. 100,p. 381 - 399
[3]European Journal of Medicinal Chemistry,2015,vol. 106,p. 15 - 25
[4]Chemistry - A European Journal,2017,vol. 23,p. 5842 - 5850
[5]Patent: WO2018/64119,2018,A1

13
[ 41153-30-4 ]
(2S)-N-[(1S)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 171 - 175

14
[ 41153-30-4 ]
2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 171 - 175

15
[ 41153-30-4 ]
[ 834888-52-7 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 171 - 175

16
[ 41153-30-4 ]
(R)-N-{(S)-2-(4-Fluoro-phenyl)-1-[(S)-4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-ethyl}-3-phenyl-2-phenylmethanesulfonylamino-propionamide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 4043 - 4049

17
[ 41153-30-4 ]
(S)-2-Amino-3-(4-fluoro-phenyl)-1-(4-hydroxy-piperidin-1-yl)-propan-1-one hydrochloride [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 2934 - 2938
[2]Patent: WO2004/104001,2004,A2
[3]Patent: WO2004/104001,2004,A2

18
[ 41153-30-4 ]
[ 149267-74-3 ]

Reference： [1]Chemistry - A European Journal,2017,vol. 23,p. 5842 - 5850
[2]Bulletin des Societes Chimiques Belges,1991,vol. 100,p. 381 - 399

19
[ 41153-30-4 ]
[ 800401-58-5 ]

Yield	Reaction Conditions	Operation in experiment
	With bis(trichloromethyl) carbonate; triethylamine; In ethyl acetate; at 20℃; for 72h;	To a solution OF 2 (S)-TERT-BUTOXYCARBONYLAMINO-3- (4-FLUOROPHENYL) propionic acid (1. 5g, 5. 29MMOL) in ethyl acetate (LOOML) under an argon atmosphere was added triphosgene (628mg, 2. 12mmol). To the solution was added triethylamine (0.8 mL 5. 76MMOL,) over Imin, and the reaction stirred for 72h at rt. The reaction mixture was filtered, and the filtrate concentrated in vacuo to yield an oily residue. The crude material was crystallised from cold dichloromethane and petroleum ether to give the title compound. 5N (CD30D): 7.20 (2H, m), 7.10 (2H, m), 5.86 (1H, s, (NH)), 4. 58 (1H, s), 3.33-3. 23 (2H, m), 3.11-3. 00 (1H, m).

Reference： [1]Patent: WO2004/104001,2004,A2 .Location in patent: Page 75-76

20
[ 41153-30-4 ]
[ 75-65-0 ]
[ 800402-10-2 ]

Yield	Reaction Conditions	Operation in experiment
	With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20℃; for 16h;	To a stirred solution of (S) -N-Boc-4-fluorophenylalanine (2. 83G, 10. OMMOL), DMAP (0.12g, L. OMMOL) in DCM (20mL) and 2-methyl-2-propanol (1. 05mL, 11. 0MMOL), was added DCC (2.27g, 11. 0MMOL). The reaction mixture was stirred at rt for 16h. The reaction mixture was filtered and washed several times with DCM. The filtrate was concentrated in vacuo and chromatographed on silica gel eluting with ethyl acetate: isohexane (1: 4) to give the title compound. aH (CDCl3): 1.39 (9H, s), 1.41 (9H, s), 3.01 (2H, m), 4.41 (1H, m), 4.98 (1H, m), 6.95 (2H, m), 7.12 (2H, m).

Reference： [1]Patent: WO2004/104001,2004,A2 .Location in patent: Page 73-74

21
[ 267876-25-5 ]
[ 41153-30-4 ]
[ 1300197-96-9 ]

Yield	Reaction Conditions	Operation in experiment
41%		Boc-4-fluoro-Phe-OH (459mg, 1.62mmol) was dissolved in CH2C12 (30mls). To this solution was added HBTU (615mg, 1.62mmol) and triethylamine (490mg, 4.86mmol). After 15mins C-(lH-pyrrolo[2,3-b]pyridin-5-yl)-methylamine (250mg, 1.7mmol) was added. After 2 hrs at room temperature the reaction mixture was diluted with CHC13 (150mls), this solution was washed with sat. NaHC03 (lx50mls), water (lx50mls), brine (lx50mls), dried (Na2S04) and evaporated in vacuo. The residue was purified by flash chromatography (silica), eluent 10% MeOH, 90% CH2C12, fractions combined and evaporated in vacuo to give a white solid identified as the title compound.Yield = 275mg, 0.67mmol, 41%[M+H]+ = 413.21

Reference： [1]Patent: WO2011/51672,2011,A1 .Location in patent: Page/Page column 70

22
[ 32955-21-8 ]
[ 41153-30-4 ]
C₁₉H₂₂FN₃O₅S [ No CAS ]

Reference： [1]European Journal of Medicinal Chemistry,2012,vol. 58,p. 624 - 639

23
[ 71086-99-2 ]
[ 41153-30-4 ]
(S)-5-[2-(tert-butoxycarbonyl)amino-3(4-fluorophenyl)propanamido]-1H-indole-2-carboxylic acid ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
71.1%	With pyridine; trichlorophosphate; In dichloromethane; at -10℃; for 2h;Inert atmosphere;	Boc-Phe (1a), (5g, 18.9mmol) was dissolved in 50mL of CH2Cl2, 5mL of pyridine and <strong>[71086-99-2]ethyl 5-amino-1H-indole-2-carboxylate</strong> (3.9g, 18.9mmol), -10 C Add phosphorus oxychloride (2.9g, 18.9mmol), add, continue stirring for 2h; add 10mL water to the reaction solution, separate the organic phase, wash once with 1M hydrochloric acid, dry, spin dry to obtain the title compound(S) 5-(2-(tert-Butoxycarbonyl)amino-3-phenylpropionamido}-1H-indole-2-carboxylic acid ethyl ester (2b), (6.6 g, yield 77.6%).
	With pyridine; trichlorophosphate; In dichloromethane; at -10℃; for 2h;	General procedure: To amixture of Boc-Phe-OH (33a) (5 g, 18.9 mmol), <strong>[71086-99-2]ethyl 5-amino-1H-indole-2-carboxylate</strong> (34) (3.9 g,18.9 mmol) and pyridine (5 mL) in CH2Cl2 (50 mL) at -10 C was added POCl3 (2.9 g, 18.9 mmol)dropwise. After addition, the reaction mixture was stirred at 10 C for 2 h when TLC analysisindicated completion of reaction, then H2O (10 mL) was added and the organic layer was separated,washed by hydrochloric acid (1 M, 10 mL), dried by Na2SO4, filtered. The filtrate was evaporated invacuum to get crude 35a as a brown solid, which was used for next step without further purification(6.6 g, 77.6% yield).

Reference： [1]Patent: CN109721539,2019,A .Location in patent: Paragraph 0105-0107
[2]Molecules,2018,vol. 23

24
[ 41153-30-4 ]
[ 198904-31-3 ]
(5S,10S,11S,14S)-11-benzyl-5,14-di-tert-butyl-3,6,13,16-tetraoxo-8-(4-(pyridin-2-yl)benzyl)-2,17-dioxa-4,7,8,12,15-pentaazaoctadecan-10-yl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoate [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2019,vol. 62,p. 3553 - 3574

25
[ 1534-90-3 ]
[ 41153-30-4 ]

Reference： [1]Journal of Medicinal Chemistry,2019,vol. 62,p. 3553 - 3574

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P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 41153-30-4 ]

Quality Control of [ 41153-30-4 ]

Related Doc. of [ 41153-30-4 ]

Product Details of [ 41153-30-4 ]

Safety of [ 41153-30-4 ]

Application In Synthesis of [ 41153-30-4 ]

[ 41153-30-4 ] Synthesis Path-Upstream 1~3

[ 41153-30-4 ] Synthesis Path-Downstream 1~25

Related Functional Groups of [ 41153-30-4 ]

Amino Acid Derivatives

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 41153-30-4 ]