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Chemical Structure| 41153-30-4 Chemical Structure| 41153-30-4
Chemical Structure| 41153-30-4

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Boc-Phe(4-F)-OH is a protected 4-fluorophenylalanine derivative with the amino group protected by tert-butoxycarbonyl (Boc), suitable for peptide synthesis.

Synonyms: (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoic acid

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Product Details of Boc-Phe(4-F)-OH

CAS No. :41153-30-4
Formula : C14H18FNO4
M.W : 283.30
SMILES Code : O=C(O)[C@H](CC1=CC=C(F)C=C1)NC(OC(C)(C)C)=O
Synonyms :
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoic acid
MDL No. :MFCD00079672
InChI Key :RCXSXRAUMLKRRL-NSHDSACASA-N
Pubchem ID :7020910

Safety of Boc-Phe(4-F)-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Boc-Phe(4-F)-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 41153-30-4 ]

[ 41153-30-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 5382-17-2 ]
  • [ 41153-30-4 ]
  • [ 186431-68-5 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20℃; for 16.0h; To a stirred solution OF BOC-3- (4-FLUOROPHENYL)- (S)-ALANINE (LO. OG, 35. 3MMOL), <strong>[5382-17-2]4-hydroxypiperidine hydrochloride</strong> (5. 1G, 37. 1MMOL) and HOBt (7.2g, 52. 9MMOL) in DMF (lOOmL), was added DIPEA (12. 3mL, 70. 6MMOL) and after 5MIN, EDCI (7.4g, 38. 8MMOL) and the reaction stirred at rt for 16H. The solvent was removed in vacuo and the residue partitioned between water (150ML) and ethyl acetate (2 x 150ML). The combined organic fractions were washed with sodium hydroxide solution (2M, 50ML), hydrochloric acid (2N, 50ML), dried (MGS04) and concentrated in vacuo. The product was chromatographed on silica gel eluting with ethyl acetate to give the title compound as a white solid. m/z (ES+) = 367 [M+ H] + ; RT = 3.28min.
  • 2
  • [ 41153-30-4 ]
  • [ 198904-31-3 ]
  • (5S,10S,11S,14S)-11-benzyl-5,14-di-tert-butyl-3,6,13,16-tetraoxo-8-(4-(pyridin-2-yl)benzyl)-2,17-dioxa-4,7,8,12,15-pentaazaoctadecan-10-yl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoate [ No CAS ]
 

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