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[ CAS No. 412925-23-6 ] {[proInfo.proName]}

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Product Details of [ 412925-23-6 ]

CAS No. :412925-23-6 MDL No. :MFCD02663205
Formula : C9H9F2NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :RXNSEGYWKJUNMR-UHFFFAOYSA-N
M.W : 201.17 Pubchem ID :588424
Synonyms :

Calculated chemistry of [ 412925-23-6 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 14
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.22
Num. rotatable bonds : 3
Num. H-bond acceptors : 5.0
Num. H-bond donors : 2.0
Molar Refractivity : 45.42
TPSA : 63.32 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -8.78 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.35
Log Po/w (XLOGP3) : -1.77
Log Po/w (WLOGP) : 1.96
Log Po/w (MLOGP) : 1.94
Log Po/w (SILICOS-IT) : 1.74
Consensus Log Po/w : 1.04

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.09
Solubility : 163.0 mg/ml ; 0.81 mol/l
Class : Very soluble
Log S (Ali) : 0.96
Solubility : 1820.0 mg/ml ; 9.03 mol/l
Class : Highly soluble
Log S (SILICOS-IT) : -2.43
Solubility : 0.749 mg/ml ; 0.00372 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.05

Safety of [ 412925-23-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 UN#:N/A
Hazard Statements:H302-H312-H332 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 412925-23-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 412925-23-6 ]

[ 412925-23-6 ] Synthesis Path-Downstream   1~19

  • 1
  • [ 85-44-9 ]
  • [ 412925-23-6 ]
  • [ 777906-01-1 ]
YieldReaction ConditionsOperation in experiment
27% In N,N-dimethyl-formamide at 135℃; 49A rac-3-(2,4-Difluorophenyl)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid Example 49A rac-3-(2,4-Difluorophenyl)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid 5.0 g of rac-3-amino-3-(2,4-difluorophenyl)propanoic acid (24.85 mmol) and 3.68 g of phthalic anhydride (24.85 mmol) were dissolved in 20 ml of DMF and the mixture was heated at reflux at 135° C. overnight. The reaction solution was added to about 160 ml of water and extracted twice with ethyl acetate. The combined organic phases were washed with water, dried over sodium sulphate, filtered and concentrated. The crude product was purified by silica gel chromatography (mobile phase: dichloromethane/methanol 80:1, isocratic) and then by preparative HPLC (RP18 column, mobile phase: acetonitrile/water gradient with addition of 0.1% TFA). This gave 3.43 g of the title compound (27% of theory). LC-MS (Method 1): Rt=1.11 min MS (ESpos): m/z=332 (M+H)+ 1H NMR (400 MHz, DMSO-d6): δ=3.24-3.3.34 (m, 1H), 3.40-3.49 (m, 1H), 5.89 (t, 1H), 7.09-7.15 (m, 1H), 7.19-7.28 (m, 1H), 7.70 (q, 1H), 7.82-7.89 (m, 4H), 12.55 (br s, 1H).
  • 2
  • [ 85-44-9 ]
  • [ 412925-23-6 ]
  • [ 1609344-58-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: N,N-dimethyl-formamide / 135 °C 2.1: triethylamine; diphenyl phosphoryl azide / toluene / 3.5 h / Inert atmosphere; Cooling 2.2: Reflux
  • 3
  • [ 141-82-2 ]
  • [ 1550-35-2 ]
  • [ 412925-23-6 ]
YieldReaction ConditionsOperation in experiment
With ammonium acetate In ethanol at 80℃; for 16h; 137.1 Step 1 : To a stirred solution of 2,4-difluorobenzaldehyde (10.0 g, 70.4 mmol, 1 equiv), malonic acid (8.78 g, 84.45 mmol, 1.2 equiv) and ammonium acetate (10.84 g, 140.8 mmol, 2 equiv) in EtOH (100 mL) was heated at 80°C for 16 h. The solid was filtered off and washed with n-pentane to give the 3-amino-3-(2,4-difluorophenyl)propanoic acid as off white solid (1 1.5 g, crude). LC-MS (ES) m/z = 202.1 [M+H] +
  • 4
  • [ 24424-99-5 ]
  • [ 412925-23-6 ]
  • 3-((tert-butoxycarbonyl)amino)-3-(2,4-difluorophenyl)propanoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate In 1,4-dioxane at 20℃; for 16h; 137.2 Step 2: To a stirred solution of 3-amino-3-(2, 4-difluorophenyl)propanoic acid (11.5 g, 57.2 mmol, 1 equiv) in dioxane (100 mL) was added sat.NaHC03 solution (100 mL) and then added Boc20 (19.7 ml_, 86 mmol, 1.5 equiv) at room temperature. The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was washed with hexane and then the aqueous layer was acidified with citric acid solution, extracted with ethyl acetate, and then dried over Na2S04 and concentrated to give the 3-((tert- butoxycarbonyl)amino)-3-(2,4-difluorophenyl)propanoic acid as white solid (11.5 g, crude). LC-MS (ES) m/z = 246.1 [M+H]+- 56.
  • 5
  • [ 412925-23-6 ]
  • 1-(4-(4-amino-7-cyclopropyl-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
  • 1-(4-(4-amino-7-cyclopropyl-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere; Sealed tube 8.1: CHIRALPAK IA / ethanol; hexane; trifluoroacetic acid / Resolution of racemate
  • 6
  • [ 412925-23-6 ]
  • 1-(4-(4-amino-7-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 100 °C / Inert atmosphere; Sealed tube
  • 7
  • [ 412925-23-6 ]
  • 1-(4-(4-amino-2,6,7-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
  • 1-(4-(4-amino-2,6,7-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere; Sealed tube 8.1: CHIRALPAK IA / ethanol; hexane; trifluoroacetic acid / Resolution of racemate
  • 8
  • [ 412925-23-6 ]
  • 1-(4-(4-amino-7-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 100 °C / Inert atmosphere; Sealed tube 8.1: CHIRALPAK IC / ethanol; hexane; trifluoroacetic acid / Resolution of racemate
  • 9
  • [ 412925-23-6 ]
  • 1-(4-(4-amino-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
  • 1-(4-(4-amino-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere; Sealed tube 8.1: CHIRALPAK IA / diethylamine; tert-butyl methyl ether; isopropyl alcohol / Resolution of racemate
  • 10
  • [ 412925-23-6 ]
  • 1-(4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 6 h / 100 °C / Inert atmosphere; Sealed tube
  • 11
  • [ 412925-23-6 ]
  • 4-(2,4-difluorophenyl)-1-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube
  • 12
  • [ 412925-23-6 ]
  • 1-(4-(4-amino-7-cyclopropyl-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere; Sealed tube
  • 13
  • [ 412925-23-6 ]
  • 1-(4-(4-amino-2,6,7-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere; Sealed tube
  • 14
  • [ 412925-23-6 ]
  • 1-(4-(4-amino-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere; Sealed tube
  • 15
  • [ 412925-23-6 ]
  • tert-butyl 5-(2,4-difluorophenyl)-2-oxoimidazolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C
  • 16
  • [ 412925-23-6 ]
  • tert-butyl 3-(4-bromo-3-fluorophenyl)-5-(2,4-difluorophenyl)-2-oxoimidazolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C
  • 17
  • [ 412925-23-6 ]
  • 1-(4-bromo-3-fluorophenyl)-4-(2,4-difluorophenyl)imidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4: hydrogenchloride / 1,4-dioxane / 20 °C
  • 18
  • [ 412925-23-6 ]
  • 1-(4-bromo-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C
  • 19
  • [ 412925-23-6 ]
  • 1-(4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-fluorophenyl)-4-(2,4-difluorophenyl)-3-methylimidazolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C 2.1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C 3.1: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 5.2: 1.5 h / 0 - 20 °C 6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 6 h / 100 °C / Inert atmosphere; Sealed tube 8.1: CHIRALPAK IA / ethyl acetate; tert-butyl methyl ether; trifluoroacetic acid / Resolution of racemate
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