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Chemical Structure| 41727-58-6 Chemical Structure| 41727-58-6

Structure of 41727-58-6

Chemical Structure| 41727-58-6

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Product Details of [ 41727-58-6 ]

CAS No. :41727-58-6
Formula : C8H6Cl2O2
M.W : 205.04
SMILES Code : O=CC1=CC(Cl)=C(OC)C(Cl)=C1
MDL No. :MFCD04070684
InChI Key :LEEKELDJRCUBEM-UHFFFAOYSA-N
Pubchem ID :883207

Safety of [ 41727-58-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P403+P233-P501

Application In Synthesis of [ 41727-58-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 41727-58-6 ]

[ 41727-58-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2314-36-5 ]
  • [ 74-88-4 ]
  • [ 41727-58-6 ]
YieldReaction ConditionsOperation in experiment
24% Preparation of 4-(3,5-dichloro-4-methoxybenzyl)-7-ethoxyisoquinolin-8-ol hydrochloride 693,5-Dichloro-4-methoxybenzaldehvde RBO 40104In a 100 ml_ round bottom flask, <strong>[2314-36-5]3,5-dichloro-4-hydroxybenzaldehyde</strong> (1 .0 g, 5.23 mmol) was dissolved in acetone (50 ml_) and K2CO3 (1 .01 g, 7.32 mmol) was added at RT. The mixture was stirred at RT for 30 min, then Mel (1 .34 g, 9.41 mmol) was added and reaction was stirred at reflux for another 5 h and finally at RT overnight. Acetone was evaporated and the residue was taken back in EtOAc (200 ml_) and water (200 ml_). The aqueous layer was further extracted with EtOAc (3x100 ml_). The combined organic layers were washed with brine (100 ml_), dried over Na2SO4, filtered and concentrated to dryness to give 3,5-dichloro-4-methoxybenzaldehyde RBO 40104 (257 mg, 24percent yield) as an off-white solid.RBO 40104MW: 205.04; Yield: 24percent; Off-white solid.1H-NMR (CDCIs, delta): 3.99 (s, 3H, OMe), 7.83 (s, 2H, 2xArH), 9.87 (s, 1 H, CHO).MS-ESI m/z (percent rel. Int.): 205.0/207.0 ([MH]+, 100/65).HPLC: Method A, XBridge.(TM). column, detection UV 254 nm, RT = 5.68 min, peak area 99.0percent.
 

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Technical Information

• Alkyl Halide Occurrence • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Julia-Kocienski Olefination • Kinetics of Alkyl Halides • Knoevenagel Condensation • Kumada Cross-Coupling Reaction • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nomenclature of Ethers • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Preparation of Ethers • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Ethers • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Stetter Reaction • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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