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[ CAS No. 43141-66-8 ]

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2D
Chemical Structure| 43141-66-8
Chemical Structure| 43141-66-8
Structure of 43141-66-8 *Storage: {[proInfo.prStorage]}

Quality Control of [ 43141-66-8 ]

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SDS

Product Details of [ 43141-66-8 ]

CAS No. :43141-66-8MDL No. :MFCD20486161
Formula : C7H5ClF2 Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :162.56Pubchem ID :640451
Synonyms :

Computed Properties of [ 43141-66-8 ]

TPSA : 0 H-Bond Acceptor Count : 2
XLogP3 : - H-Bond Donor Count : 0
SP3 : 0.14 Rotatable Bond Count : 1

Safety of [ 43141-66-8 ]

Signal Word:WarningClassN/A
Precautionary Statements:P305+P351+P338UN#:N/A
Hazard Statements:H227-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 43141-66-8 ]

  • Upstream synthesis route of [ 43141-66-8 ]
  • Downstream synthetic route of [ 43141-66-8 ]

[ 43141-66-8 ] Synthesis Path-Upstream   1~10

  • 1
  • [ 104-88-1 ]
  • [ 43141-66-8 ]
Reference: [1] Journal of Fluorine Chemistry, 2001, vol. 111, # 2, p. 153 - 160
[2] Chemische Berichte, 1988, vol. 121, p. 1329 - 1340
[3] Synthesis, 1973, p. 787 - 789
[4] Patent: WO2009/121939, 2009, A2. Location in patent: Page/Page column 58-59
  • 2
  • [ 637-87-6 ]
  • [ 43141-66-8 ]
Reference: [1] Organic Letters, 2016, vol. 18, # 15, p. 3690 - 3693
  • 3
  • [ 75-45-6 ]
  • [ 69519-09-1 ]
  • [ 43141-66-8 ]
YieldReaction ConditionsOperation in experiment
80 %Spectr. With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone; [5-(diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphane In 1,4-dioxane at 110℃; for 48.00 h; Inert atmosphere; Sealed tube General procedure: To a 25 ml sealed tube were added anhydrous K2CO3 (powder, 4.0 equiv.), hydroquinone (2.0 equiv.), Pd2(dba)3 (2.5 molpercent), Xantphos (7.5 molpercent) and ArB(OH)2 (0.3 or 0.5 mmol) or Ar-Beg (0.3 or 0.5 mmol) under argon. A solution of ClCF2H in 1,4-dioxane (2.0 M, 1.5 ml for 0.3 mmol scale or 2.5 ml for 0.5 mmol scale, 10 equiv.) and fresh distilled 1,4-dioxane (1.0 ml for 0.3 mmol scale or 2.5 ml for 0.5 mmol scale) were added subsequently. The sealed tube was screw capped and heated to 110 °C (oil bath). After stirring for 48 h, the reaction was cooled to room temperature and fluorobenzene (1.0 equiv.) was added. The yield was determined by 19F NMR before working up. The reaction mixture was then diluted with ethyl acetate, filtered through a pad of Celite and concentrated. The residue was purified with silica gel chromatography to provide the desired product.
Reference: [1] Nature Chemistry, 2017, vol. 9, # 9, p. 918 - 923
  • 4
  • [ 106-47-8 ]
  • [ 43141-66-8 ]
Reference: [1] Organic Letters, 2014, vol. 16, # 22, p. 5984 - 5987
  • 5
  • [ 106-39-8 ]
  • [ 43141-66-8 ]
Reference: [1] Organic Letters, 2018, vol. 20, # 17, p. 5340 - 5343
  • 6
  • [ 637-87-6 ]
  • [ 1438388-96-5 ]
  • [ 43141-66-8 ]
Reference: [1] Angewandte Chemie - International Edition, 2012, vol. 51, # 48, p. 12090 - 12094[2] Angew. Chem., 2012, vol. 124, # 48, p. 12256 - 12260,5
  • 7
  • [ 106-39-8 ]
  • [ 395-01-7 ]
  • [ 43141-66-8 ]
Reference: [1] Journal of the American Chemical Society, 2014, vol. 136, # 11, p. 4149 - 4152
  • 8
  • [ 106-39-8 ]
  • [ 1511-62-2 ]
  • [ 43141-66-8 ]
Reference: [1] Angewandte Chemie - International Edition, 2018, vol. 57, # 38, p. 12543 - 12548[2] Angew. Chem., 2018, vol. 130, p. 12723 - 12728,6
  • 9
  • [ 637-87-6 ]
  • [ 43141-66-8 ]
  • [ 369-54-0 ]
Reference: [1] Journal of the American Chemical Society, 2016, vol. 138, # 8, p. 2536 - 2539
  • 10
  • [ 108-90-7 ]
  • [ 43141-66-8 ]
Reference: [1] Organometallics, 2015, vol. 34, # 12, p. 3065 - 3071
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