Home Cart 0 Sign in  

[ CAS No. 4319-87-3 ]

{[proInfo.proName]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 4319-87-3
Chemical Structure| 4319-87-3
Structure of 4319-87-3 *Storage: {[proInfo.prStorage]}

Quality Control of [ 4319-87-3 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 4319-87-3 ]

SDS

Product Details of [ 4319-87-3 ]

CAS No. :4319-87-3MDL No. :MFCD19382397
Formula :C6H7BrN2OBoiling Point :266.6±35.0°C at 760 mmHg
Linear Structure Formula :-InChI Key :YDPPNMNAHGZFDJ-UHFFFAOYSA-N
M.W :203.04Pubchem ID :56592978
Synonyms :

Computed Properties of [ 4319-87-3 ]

TPSA : 35 H-Bond Acceptor Count : 3
XLogP3 : 1.6 H-Bond Donor Count : 0
SP3 : 0.33 Rotatable Bond Count : 1

Safety of [ 4319-87-3 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 4319-87-3 ]

  • Upstream synthesis route of [ 4319-87-3 ]
  • Downstream synthetic route of [ 4319-87-3 ]

[ 4319-87-3 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 124-41-4 ]
  • [ 3438-55-9 ]
  • [ 4319-87-3 ]
YieldReaction ConditionsOperation in experiment
79% at 20℃; for 1.00 h; Sodium methoxide (25 wtpercent solution in methanol, 1.83 mL, 16.0 mmol) was added to a solution of 5-bromo-4-chloro-6-methylpyrimidine (1.85 g, 8.92 mmol) in methanol (50 mL) and the reaction was stirred at ambient temperature for 1 hour. The reaction was quenched by the addition of pH 7 buffer. The majority of the methanol was removed under reduced pressure. The aqueous portion was diluted with water and was extracted with diethyl ether three times. The combined organic extracts were washed with brine, dried over Na2S04, filtered and concentrated to afford 5- bromo-4-methoxy-6-methylpyrimidine (1.43 g, 79percent). 1H NMR (CDC13, 400 MHz): 8 8.48 (s, 1H); 4.00 (s, 3H); 2.54 (s, 3H). MS (ES) 204(M+1).
Reference: [1] Patent: WO2005/105814, 2005, A1. Location in patent: Page/Page column 67-68
  • 2
  • [ 67-56-1 ]
  • [ 3438-55-9 ]
  • [ 4319-87-3 ]
Reference: [1] Synthesis, 2011, # 10, p. 1529 - 1531
  • 3
  • [ 3524-87-6 ]
  • [ 4319-87-3 ]
Reference: [1] Synthesis, 2011, # 10, p. 1529 - 1531
Historical Records

Related Functional Groups of
[ 4319-87-3 ]

Bromides

Chemical Structure| 3438-52-6

[ 3438-52-6 ]

5-Bromo-6-methylpyrimidin-4-ol

Similarity: 0.92

Chemical Structure| 4319-85-1

[ 4319-85-1 ]

5-Bromo-4-methoxypyrimidine

Similarity: 0.83

Chemical Structure| 1240602-39-4

[ 1240602-39-4 ]

5-Bromo-2-methyl-6-(trifluoromethyl)pyrimidin-4-ol

Similarity: 0.76

Chemical Structure| 56686-16-9

[ 56686-16-9 ]

5-Bromo-2,4-dimethoxypyrimidine

Similarity: 0.75

Chemical Structure| 36082-45-8

[ 36082-45-8 ]

2-Amino-5-bromo-4-methoxypyrimidine

Similarity: 0.75

Ethers

Chemical Structure| 4319-85-1

[ 4319-85-1 ]

5-Bromo-4-methoxypyrimidine

Similarity: 0.83

Chemical Structure| 56686-16-9

[ 56686-16-9 ]

5-Bromo-2,4-dimethoxypyrimidine

Similarity: 0.75

Chemical Structure| 36082-45-8

[ 36082-45-8 ]

2-Amino-5-bromo-4-methoxypyrimidine

Similarity: 0.75

Chemical Structure| 5541-07-1

[ 5541-07-1 ]

4-Methoxy-6-methylpyrimidine

Similarity: 0.73

Chemical Structure| 717843-47-5

[ 717843-47-5 ]

3-Bromo-2-methoxy-6-methylpyridine

Similarity: 0.72

Related Parent Nucleus of
[ 4319-87-3 ]

Aromatic Heterocycles

Chemical Structure| 3438-52-6

[ 3438-52-6 ]

5-Bromo-6-methylpyrimidin-4-ol

Similarity: 0.92

Chemical Structure| 4319-85-1

[ 4319-85-1 ]

5-Bromo-4-methoxypyrimidine

Similarity: 0.83

Chemical Structure| 1240602-39-4

[ 1240602-39-4 ]

5-Bromo-2-methyl-6-(trifluoromethyl)pyrimidin-4-ol

Similarity: 0.76

Chemical Structure| 56686-16-9

[ 56686-16-9 ]

5-Bromo-2,4-dimethoxypyrimidine

Similarity: 0.75

Chemical Structure| 36082-45-8

[ 36082-45-8 ]

2-Amino-5-bromo-4-methoxypyrimidine

Similarity: 0.75

Pyrimidines

Chemical Structure| 3438-52-6

[ 3438-52-6 ]

5-Bromo-6-methylpyrimidin-4-ol

Similarity: 0.92

Chemical Structure| 4319-85-1

[ 4319-85-1 ]

5-Bromo-4-methoxypyrimidine

Similarity: 0.83

Chemical Structure| 1240602-39-4

[ 1240602-39-4 ]

5-Bromo-2-methyl-6-(trifluoromethyl)pyrimidin-4-ol

Similarity: 0.76

Chemical Structure| 56686-16-9

[ 56686-16-9 ]

5-Bromo-2,4-dimethoxypyrimidine

Similarity: 0.75

Chemical Structure| 36082-45-8

[ 36082-45-8 ]

2-Amino-5-bromo-4-methoxypyrimidine

Similarity: 0.75