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CAS No. : | 433969-27-8 | MDL No. : | MFCD05663974 |
Formula : | C12H18BNO4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | N/A |
M.W : | 251.09 | Pubchem ID : | - |
Synonyms : |
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TPSA :Topological Polar Surface Area | - | H-Bond Acceptor Count : | - |
XLogP3 : | - | H-Bond Donor Count : | - |
SP3 : | - | Rotatable Bond Count : | - |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P305+P351+P338-P304+P340-P405-P501 | UN#: | N/A |
Hazard Statements: | H302 | Packing Group: | N/A |
GHS Pictogram: |
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Yield | Reaction Conditions | Operation in experiment |
---|---|---|
240 mg | With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 100℃; for 1.5h;Inert atmosphere; | To a solution of compound A20 (300 mg, 1.68 mmol) and compound A19 (506 mg, 2.02 mmol) in dioxane (5 mL) and H20 (1 mL) was added CS2CO3 (547 mg, 1.68 mmol), Pd(dppf)Cl2 (123 mg, 0.168 mmol) under N2. The resulting mixture was heated at l00C and stirred for 1.5 hours to give black suspension. LCMS and TLC showed the reaction was completed. The reaction mixture was quenched by addition H20 (50 mL) and extracted with EtOAc (50 mL x 2). The combined organic layers were washed with brine (20 mL x 2), dried over Na2S04, filtered and concentrated under reduced pressure to give a residue. The residue was purified by combi flash to give compound A21 (240 mg) as a yellow solid. |