Alternatived Products of [ 442633-00-3 ]
Product Details of [ 442633-00-3 ]
CAS No. : | 442633-00-3 |
MDL No. : | MFCD03036271 |
Formula : |
C18H17FN2O
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | UXRKUKRXVWJFER-UHFFFAOYSA-N |
M.W : |
296.34
|
Pubchem ID : | 589075 |
Synonyms : |
|
Safety of [ 442633-00-3 ]
Application In Synthesis of [ 442633-00-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 442633-00-3 ]
- 1
-
[ 95-20-5 ]
-
[ 442633-00-3 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 5 steps
1: trichlorophosphate / N,N-dimethyl-formamide
2: ammonium acetate
3: sodium tris(acetoxy)borohydride / tetrahydrofuran
4: palladium 10% on activated carbon; ammonium formate / methanol
5: triethylamine / tetrahydrofuran / 0.5 h / 20 °C |
|
Reference:
[1]Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J.
[ChemMedChem, 2012, vol. 7, # 7, p. 1286 - 1294]
- 2
-
[ 5416-80-8 ]
-
[ 442633-00-3 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: ammonium acetate
2: sodium tris(acetoxy)borohydride / tetrahydrofuran
3: palladium 10% on activated carbon; ammonium formate / methanol
4: triethylamine / tetrahydrofuran / 0.5 h / 20 °C |
|
Reference:
[1]Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J.
[ChemMedChem, 2012, vol. 7, # 7, p. 1286 - 1294]
- 3
-
[ 2826-91-7 ]
-
[ 442633-00-3 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: sodium tris(acetoxy)borohydride / tetrahydrofuran
2: palladium 10% on activated carbon; ammonium formate / methanol
3: triethylamine / tetrahydrofuran / 0.5 h / 20 °C |
|
Reference:
[1]Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J.
[ChemMedChem, 2012, vol. 7, # 7, p. 1286 - 1294]
- 4
-
[ 2731-06-8 ]
-
[ 393-52-2 ]
-
[ 442633-00-3 ]
Yield | Reaction Conditions | Operation in experiment |
0.05 g |
With triethylamine In tetrahydrofuran at 20℃; for 0.5h; |
|
|
Stage #1: 2-methyl-3-(2-aminoethyl)indole With triethylamine In dichloromethane at 20℃; for 1h;
Stage #2: 2-Fluorobenzoyl chloride In dichloromethane at 0 - 20℃; for 3h; |
|
Reference:
[1]Location in patent: experimental part
Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J.
[ChemMedChem, 2012, vol. 7, # 7, p. 1286 - 1294]
[2]Fokin, Artem I.; Chuprov-Netochin, Roman N.; Malyshev, Alexander S.; Romero, Stéphane; Semenova, Marina N.; Konyushkin, Leonid D.; Leonov, Sergey V.; Semenov, Victor V.; Gautreau, Alexis M.
[Frontiers in Pharmacology, 2022, vol. 13]
- 5
-
C11H12N2
[ No CAS ]
-
[ 442633-00-3 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; ammonium formate / methanol
2: triethylamine / tetrahydrofuran / 0.5 h / 20 °C |
|
Reference:
[1]Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J.
[ChemMedChem, 2012, vol. 7, # 7, p. 1286 - 1294]