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Chemical Structure| 442633-00-3 Chemical Structure| 442633-00-3

Structure of CK-666
CAS No.: 442633-00-3

Chemical Structure| 442633-00-3

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CK 666 is an inhibitor of Arp2/3 complex. It can inhibit actin polymerization (IC50 = 4 μM).

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Product Details of CK-666

CAS No. :442633-00-3
Formula : C18H17FN2O
M.W : 296.34
SMILES Code : CC(NC1=CC=CC=C21)=C2CCNC(C3=C(F)C=CC=C3)=O
MDL No. :MFCD03036271
InChI Key :UXRKUKRXVWJFER-UHFFFAOYSA-N
Pubchem ID :589075

Safety of CK-666

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330-P501

Related Pathways of CK-666

cytoskeleton

Isoform Comparison

Biological Activity

Description
CK-666 is a potent inhibitor of the Arp2/3 complex, an actin-related protein, displaying an IC50 value of 12 μM. By binding to the Arp2/3 complex, CK-666 stabilizes its inactive form and prevents the movement of Arp2 and Arp3 subunits into an activated, filament-like conformation[1].[2].

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Bio Calculators
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1 mM

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10 mM

3.37mL

0.67mL

0.34mL

16.87mL

3.37mL

1.69mL

33.75mL

6.75mL

3.37mL

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