Alternatived Products of [ 475278-46-7 ]
Product Details of [ 475278-46-7 ]
CAS No. : | 475278-46-7 |
MDL No. : | MFCD16744215 |
Formula : |
C8H9FN2O2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
184.17
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 475278-46-7 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 475278-46-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 475278-46-7 ]
- 1
-
[ 700-36-7 ]
-
[ 75-04-7 ]
-
[ 475278-46-7 ]
Yield | Reaction Conditions | Operation in experiment |
71% |
|
Under Argon and at RT, Pd(OAc)2 (33 mg, 0.15 mmol) and BINAP (101 mg, 0.16 mmol) were added to a solution of 2 M ethylamine/THF (3.8 mL, 7.6 mmol) and 4-fluoro-2-bromonitrobenzene (647 mg, 2.94 mmol) in toluene (degassed by purging, 3 mL). The reaction mixture was heated at 90 C. for 3 minutes and then cooled to 0 C. Upon addition of sodium tert-butoxide (452 mg, 4.70 mmol) the reaction mixture turned red. The reaction was stirred at 70 C. for 22 hours. The reaction was filtered over Kiezelguhr. Rinsed with EtOAc (100 mL). The filtrate was washed with brine (100 mL). The brine-layer was extracted once with EtOAc (100 mL). The combined EtOAc-extracts were dried (Na2SO4), filtered, and evaporated to dryness in vacuo. The crude product was purified by column chromatography (heptane to EtOAc/heptane: 1/20) to obtain the title compound as a yellow solid (382 mg, 71%, purity (GC)>95%).MS: [M]+=184. |