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[ CAS No. 477312-25-7 ]

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Chemical Structure| 477312-25-7

Chemical Structure| 477312-25-7

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Quality Control of [ 477312-25-7 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 477312-25-7 ]

Product Details of [ 477312-25-7 ]

CAS No. :	477312-25-7	MDL No. :	MFCD16617621
Formula :	C₉H₁₀F₃NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	XRRKIDIISISOKH-UHFFFAOYSA-N
M.W :	205.17	Pubchem ID :	22605542
Synonyms :

Calculated chemistry of [ 477312-25-7 ]

Physicochemical Properties

Num. heavy atoms :	14
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.33
Num. rotatable bonds :	3
Num. H-bond acceptors :	5.0
Num. H-bond donors :	1.0
Molar Refractivity :	45.61
TPSA :	35.25 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.88 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.18
Log Po/w (XLOGP3) :	2.36
Log Po/w (WLOGP) :	3.54
Log Po/w (MLOGP) :	1.98
Log Po/w (SILICOS-IT) :	2.17
Consensus Log Po/w :	2.45

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.72
Solubility :	0.393 mg/ml ; 0.00191 mol/l
Class :	Soluble
Log S (Ali) :	-2.74
Solubility :	0.373 mg/ml ; 0.00182 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.11
Solubility :	0.16 mg/ml ; 0.000782 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.89

Safety of [ 477312-25-7 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 477312-25-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 477312-25-7 ]

[ 477312-25-7 ] Synthesis Path-Downstream 1~7

1
[ 85013-98-5 ]
[ 477312-25-7 ]

Yield	Reaction Conditions	Operation in experiment
	With ammonium acetate; sodium cyanoborohydride; In methanol; at 120℃; for 0.0833333h;	An Emrys Process Vial (2-5 ml) was charged with 420 mg (2 mmol) of 1-(4- trifluoromethoxy-phenyl)-ethanone, ammonium acetate in MeOH (4.0 ml of a 5 M solution, 20 mmol) and sodium cyanoborohydride in MeOH (0.440 ml of a 5 M solution, 2.2 mmol). The reaction vessel was sealed and heated to 120°C for 5 min in an Emrys Optimizer. After cooling and manual release of remaining pressure the vessel was uncapped and the reaction mixture concentrated at reduced pressure. The residue was dissolved in Et20 (10 ml) and extracted with 2 M aqueous HCI (3 x 5 ml). The combined aqueous phases were adjusted to pH 9 with a 10 M aqueous KOH and extracted with CH2C12 (4 x 10 ml). The combined organic phases were dried over MgS04 and the solvent evaporated at reduced pressure to afford 1-(3- trifluoromethoxy-phenyl)-ethyl amine which is used as crude product for step 2.

Reference： [1]Patent: WO2005/121119,2005,A1 .Location in patent: Page/Page column 30

2
ethylene dichloride hydrochloride [ No CAS ]
[ 477312-25-7 ]
[ 54495-51-1 ]
[ 477308-96-6 ]

Yield	Reaction Conditions	Operation in experiment
	With dmap; triethylamine; In dichloromethane;	Example 218 Preparation of (+-)-3-Pyridin-2-yl-N-[1-(3-trifluoromethoxyphenyl)-ethyl]acrylamide To a solution of 3-(pyridin-2-yl)acrylic acid, Preparation 16 (50 mg) in CH2Cl2 (2 mL) at room temperature were added (+-)-1-(3-trifluoromethoxy phenyl)ethylamine, Preparation 15 (76 mg), EDC hydrochloride (129 mg), DMAP (41 mg), and triethylamine (0.2 mL), and the resulting solution was stirred at room temperature for 12 hours. The crude product was purified by silica gel chromatography eluding with ethyl acetate to provide the title compound as the racemate (96 mg). This racemate was separated by HPLC using AD column eluding with hexanes/ethanol (9:1) to give the title compound as an enantiomer of undetermined chirality. 1H NMR (CDCl3, 300 mHz) δ: 1.55 (3H, d, J=6.9 Hz), 5.28 (1H, quintet, J=7.1 Hz), 6.08 (1H, d, J=7.6 Hz), 7.02 (1H, d, J=15.1 Hz), 7.10-7.45 (6H, m), 7.62 (1H, d, J=15.1 Hz), 7.69 (1H, m), 8.59 (1H, d, J=4.4 Hz). MS: 337 [M+H]+

Reference： [1]Patent: US2003/166650,2003,A1

3
2-phenyl-4-trifluoromethyl-thiazole-5-carboxylic acid [ No CAS ]
[ 477312-25-7 ]
2-phenyl-4-trifluoromethyl-thiazole-5-carboxylic acid [1-(3-trifluoromethoxyphenyl)-ethyl]-amide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
42%		2-Phenyl-4-trifluoromethyl-thiazole-5-carboxylic acid [1-(3-trifluoromethoxyphenyl)-ethyl]-amide. To a solution of 2-phenyl-4-trifluoromethyl-thiazole-5-carboxylic acid (35 mg, 0.128 mmol) in DMF (1 mL) was added PyBOP (73 mg, 0.141 mmol) and DMAP (16 mg, 0.128 mmol). A solution of 1-(3-trifluoromethoxyphenyl)-ethylamine (27 mg, 0.128 mmol) in DMF (0.5 mL) was then added, followed by Et3N (36 μL, 0.256 mmol). This mixture was stirred at 25 C. for 18 h. The reaction mixture was applied directly to a preparatory HPLC column for purification (C18, 10-100% methanol/water/0.1% trifluoroacetic acid) which gave the amide as a white solid (24.9 mg, 42%).

Reference： [1]Patent: US2004/147401,2004,A1 .Location in patent: Page 33

4
[ 477312-25-7 ]
[ 1514568-53-6 ]
[ 1610853-10-5 ]

Yield	Reaction Conditions	Operation in experiment
58%		f) Synthesis of 4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide To a stirred solution of 4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-thiazole-5-carboxylic acid (0.15 g, 0.53 mmol) in dimethylformamide (3 ml) are added N-methylmorpholine (0.12 ml, 1.06 mmol), O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate (0.25 g, 0.79 mmol) at 0 C. The reaction mixture is stirred at 0 C. for 5 min before <strong>[477312-25-7]1-[3-(trifluoromethyloxy)-phenyl]-ethyl-amine</strong> (0.13 g, 0.63 mmol) is added. The reaction mixture is then stirred at RT for 16 h. After completion of the reaction, the reaction mixture is diluted with EtOAc (10 ml). The organic layer is washed with saturated sodium hydrogen carbonate solution (15 ml), saturated ammonium chloride solution (15 ml), water (20 ml), and brine (20 ml), dried over sodium sulfate and evaporated to dryness to get the crude product, which is purified by column chromatography (silica gel, 5% acetone/hexane) followed by crystallization from acetone/pentane affording 4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide (example 9) (0.15 g, 0.31 mmol, 58%). [M+H]+ 472.2.
58%		To a stirred solution of 4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-thiazole-5-carboxylic acid (0.15g, 0.53 mmol) in dimethylformamide (3 ml) are added N-methylmorpholine (0.12 ml, 1.06 mmol), O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate (0.25 g, 0.79 mmol) at 0 C. The reaction mixture is stirred at 0 C for 5 min before 1 -[3 -(trifluoromethyloxy)-phenyl]-ethyl-amine (0.13 g,0.63 mmol) is added. The reaction mixture is then stirred at RT for 16 h. After completion of the reaction, the reaction mixture is diluted with EtOAc (10 ml). The organic layer is washed with saturated sodiumhydrogen carbonate solution (15 ml), saturated ammonium chloride solution (15 ml), water ( 2 0 ml), and brine ( 2 0 ml), dried over sodium sulfate and evaporated to dryness to get the crude product, which is purified by column chromatography (silica gel, 5% acetone/ hexane) followed by crystallization fromacetone/pentane affording 4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1 -[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide (exam ple 9) (0.15 g, 0.31 mmol,58%). [M+H]+ 472.2.

Reference： [1]Patent: US2014/148454,2014,A1 .Location in patent: Paragraph 0714; 0720
[2]Patent: WO2014/82739,2014,A1 .Location in patent: Page/Page column 68; 69

5
[ 477312-25-7 ]
1-(2-methylpyridin-4-yl)-1H-pyrazolo[3,4-c]pyridin-5-amine [ No CAS ]
[ 530-62-1 ]
1-(1-(2-methylpyridin-4-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)-3-(1-(3-(trifluoromethoxy)phenyl)ethyl)urea trifluoroacetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		A solution of l-(2-methylpyridin-4-yl)-lH-pyrazolo[3,4-c]pyridin-5-amine (25 mg, 0.11 mmol) in dioxane (1 mL) was treated with imidazole (40 mg, 0.59 mmol) and carbonyl diimidazole (100 mg, 0.62 mmol). The mixture was stirred for 3 hours. An aliquot was treated with methanol, and the presence of the corresponding methyl carbamate as observed by LC/MS was used to indicate consumption of the aminopyridine. Next, l-(3- (0738) (trifluoromethoxy)phenyl)ethanamine (110 mg, 0.54 mmol) was added followed by TEA (0.10 mL, 0.72 mmol) and the mixture stirred for 2 hours, then concentrated to dryness. The residue was dissolved in DMSO and purified by reverse phase chromatography (MeCN/water with 0.1% TFA). The LC fractions were lyophilized to provide the TFA salt of l-(l-(2-methylpyridin-4-yl)- lH-pyrazolo[3,4-c]pyridin-5-yl)-3-(l-(3-(trifluoromethoxy)-phenyl)ethyl)urea: MS (EI) calc'd for C22H2oF3N602 [M+H]+ 457, found 457; 1H NMR (600 MHz, OMSO-d6) δ 9.40 (s, 1 H), 9.24 (s, 1 H), 8.70 (d, J= 6.5 Hz, 1 H), 8.68 (s, 1 H), 8.16 (s, 1 H), 8.14 (s, 1 H), 8.11 (d, J= 5.6 Hz, 1 H), 7.52 (d, J= 6.4 Hz, 1 H), 7.46 (t, J= 7.9 Hz, 1 H), 7.38 (d, J= 7.9 Hz, 1 H), 7.29 (s, 1 H), 7.21 (d, J= 7.6 Hz, 1 H), 4.91 (dt, J= 7.1 Hz, 1 H), 2.70 (s, 3 H), 1.40 (d, J= 7.1 Hz, 3 H)

Reference： [1]Patent: WO2016/100050,2016,A1 .Location in patent: Page/Page column 95

6
[ 477312-25-7 ]
5-(2-aminobenzo[d]thiazol-6-yl)-2-methoxynicotinic acid [ No CAS ]
5-(2-aminobenzo[d]thiazol-6-yl)-2-methoxy-N-(1-(3-(trifluoromethoxy)phenyl)ethyl)nicotinamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine;	Step 2: 5-(2-Aminobenzo[d]thiazol-6-yl)-2-methoxynicotinic acid (225mg, 0.4762mmol) and 15mL of N,N-dimethylformamide were added to a 50mL round-bottomed flask. Next, 1-(3-(trifluoromethoxy)phenyl)ethyl-1-amine (146.54mg, 0.7143mmol), triethylamine (480mg, 4.672mmol), and BOP reagent (330mg, 0.7467mmol) were added sequentially. The reaction was carried out overnight at room temperature under the protection of nitrogen gas. 80mL of ethyl acetate was added to the system. The resultant mixture was washed with saturated brine for 5 times (50mL*5). The organic phase of ethyl acetate was dried over anhydrous sodium sulfate and filtered, and the filtrate was spin-dried to give 5-(2-aminobenzo[d]thiazol-6-yl)-2-methoxy-N-(1-(3-(trifluoromethoxy)phenyl)ethyl) nicotinamide Z3 (40mg, Y:17%). ES-API:[M+H]+=489.1. 1H NMR (400 MHz, DMSO-d6) δ 8.73 (d, J = 7.9 Hz, 1H), 8.55 (d, J = 2.5 Hz, 1H), 8.15 (d, J = 2.5 Hz, 1H), 7.99 (d, J= 1.8 Hz, 1H), 7.61 - 7.33 (m, 7H), 7.21 (d, J = 7.2 Hz, 1H), 5.16 (p, J = 7.0 Hz, 1H), 3.97 (s, 3H), 1.44 (d, J = 7.0 Hz, 3H).
40 mg	With benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20℃;Inert atmosphere;	5-(2-Aminobenzo[d]thiazol-6-yl)-2-methoxynicotinic acid (225mg, 0.4762mmol) and 15mL of N,N-dimethylformamide were added to a 50mL round-bottomed flask. Next, 1-(3-(trifluoromethoxy)phenyl)ethyl-1-amine (146.54mg, 0.7143mmol), triethylamine (480mg, 4.672mmol), and BOP reagent (330mg, 0.7467mmol) were added sequentially. The reaction was carried out overnight at room temperature under the protection of nitrogen gas. 80mL of ethyl acetate was added to the system. The resultant mixture was washed with saturated brine for 5 times (50mL*5). The organic phase of ethyl acetate was dried over anhydrous sodium sulfate and filtered, and the filtrate was spin-dried to give 5-(2-aminobenzo[d]thiazol-6-yl)-2-methoxy-N-(1-(3-(trifluoromethoxy)phenyl)ethyl) nicotinamide Z3 (40mg, Y:17%). ES-API:[M+H]+=489.1. 1H NMR (400 MHz, DMSO-d6) δ 8.73 (d, J = 7.9 Hz, 1H), 8.55 (d, J = 2.5 Hz, 1H), 8.15 (d, J = 2.5 Hz, 1H), 7.99 (d, J= 1.8 Hz, 1H), 7.61 - 7.33 (m, 7H), 7.21 (d, J = 7.2 Hz, 1H), 5.16 (p, J = 7.0 Hz, 1H), 3.97 (s, 3H), 1.44 (d, J = 7.0 Hz, 3H).
40 mg	With benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20℃;Inert atmosphere;	5-(2-Aminobenzo[d]thiazol-6-yl)-2-methoxynicotinic acid (225mg, 0.4762mmol) and 15mL of N,N-dimethylformamide were added to a 50mL round-bottomed flask. Next, 1-(3-(trifluoromethoxy)phenyl)ethyl-1-amine (146.54mg, 0.7143mmol), triethylamine (480mg, 4.672mmol), and BOP reagent (330mg, 0.7467mmol) were added sequentially. The reaction was carried out overnight at room temperature under the protection of nitrogen gas. 80mL of ethyl acetate was added to the system. The resultant mixture was washed with saturated brine for 5 times (50mL*5). The organic phase of ethyl acetate was dried over anhydrous sodium sulfate and filtered, and the filtrate was spin-dried to give 5-(2-aminobenzo[d]thiazol-6-yl)-2-methoxy-N-(1-(3-(trifluoromethoxy)phenyl)ethyl) nicotinamide Z3 (40mg, Y:17%). ES-API:[M+H]+=489.1. 1H NMR (400 MHz, DMSO-d6) δ 8.73 (d, J = 7.9 Hz, 1H), 8.55 (d, J = 2.5 Hz, 1H), 8.15 (d, J = 2.5 Hz, 1H), 7.99 (d, J= 1.8 Hz, 1H), 7.61 - 7.33 (m, 7H), 7.21 (d, J = 7.2 Hz, 1H), 5.16 (p, J = 7.0 Hz, 1H), 3.97 (s, 3H), 1.44 (d, J = 7.0 Hz, 3H).

40 mg

With benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20℃;Inert atmosphere;

5-(2-Aminobenzo[d]thiazol-6-yl)-2-methoxynicotinic acid (225mg, 0.4762mmol) and 15mL of N,N-dimethylformamide were added to a 50mL round-bottomed flask. Next, 1-(3-(trifluoromethoxy)phenyl)ethyl-1-amine (146.54mg, 0.7143mmol), triethylamine (480mg, 4.672mmol), and BOP reagent (330mg, 0.7467mmol) were added sequentially. The reaction was carried out overnight at room temperature under the protection of nitrogen gas. 80mL of ethyl acetate was added to the system. The resultant mixture was washed with saturated brine for 5 times (50mL*5). The organic phase of ethyl acetate was dried over anhydrous sodium sulfate and filtered, and the filtrate was spin-dried to give 5-(2-aminobenzo[d]thiazol-6-yl)-2-methoxy-N-(1-(3-(trifluoromethoxy)phenyl)ethyl) nicotinamide Z3 (40mg, Y:17%). ES-API:[M+H]+=489.1. 1H NMR (400 MHz, DMSO-d6) δ 8.73 (d, J = 7.9 Hz, 1H), 8.55 (d, J = 2.5 Hz, 1H), 8.15 (d, J = 2.5 Hz, 1H), 7.99 (d, J= 1.8 Hz, 1H), 7.61 - 7.33 (m, 7H), 7.21 (d, J = 7.2 Hz, 1H), 5.16 (p, J = 7.0 Hz, 1H), 3.97 (s, 3H), 1.44 (d, J = 7.0 Hz, 3H).

Reference： [1]Patent: EP3943488,2022,A1
[2]Patent: EP3943488,2022,A1 .Location in patent: Paragraph 0159; 0161
[3]Patent: EP3943488,2022,A1 .Location in patent: Paragraph 0159; 0161
[4]Patent: EP3943488,2022,A1 .Location in patent: Paragraph 0159; 0161

7
[ 477312-25-7 ]
[ 22287-35-0 ]
[ 530-62-1 ]
1-bicyclo[1.1.1]pent-1-yl-3-[1-(3-trifluoromethoxyphenyl)ethyl]urea [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		To a solution of bicyclo[1.1.1]pentan-1-amine hydrochloride (12 mg, 0.1 mmol, 1 eq) in MeCN (0.5 mL), DIPEA (34 μL, 0.2 mmol, 2 eq) and CDI (16 mg, 0.1 mmol, 1 eq) were added in sequence. The mixture was stirred at 60 C for 1 hour. A solution of 1-(3- (trifluoromethoxy)phenyl)ethanamine (21 mg, 0.1 mmol, 1 eq) in MeCN (0.4 mL) and H2O (0.1 mL) was added. The reaction mixture was further stirred at 60 C overnight. The mixture was allowed to cool to rt and purified by prep. HPLC (column: Waters XBridge, 30x75 mm, 10 um, UV/MS, basic conditions). LC-MS (1): tR = 1.11min; [M+H]+: 315.2.

Reference： [1]Patent: WO2021/260090,2021,A1 .Location in patent: Page/Page column 41

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P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere