[ CAS No. 4774-15-6 ] {[proInfo.proName]}

Name: 4774-15-6|2,6-Dimethoxypyrazine|98%
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Quality Control of [ 4774-15-6 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 4774-15-6 ]

SDS Specification

Alternatived Products of [ 4774-15-6 ]

Product Details of [ 4774-15-6 ]

CAS No. :	4774-15-6	MDL No. :	MFCD00955843
Formula :	C₆H₈N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	FCLZSYLOQPRJMS-UHFFFAOYSA-N
M.W :	140.14	Pubchem ID :	3264170
Synonyms :

Calculated chemistry of [ 4774-15-6 ]

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.33
Num. rotatable bonds :	2
Num. H-bond acceptors :	4.0
Num. H-bond donors :	0.0
Molar Refractivity :	35.02
TPSA :	44.24 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.03 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.04
Log Po/w (XLOGP3) :	1.58
Log Po/w (WLOGP) :	0.49
Log Po/w (MLOGP) :	-0.52
Log Po/w (SILICOS-IT) :	0.85
Consensus Log Po/w :	0.89

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.02
Solubility :	1.35 mg/ml ; 0.00963 mol/l
Class :	Soluble
Log S (Ali) :	-2.12
Solubility :	1.06 mg/ml ; 0.00759 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-1.88
Solubility :	1.84 mg/ml ; 0.0132 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.69

Safety of [ 4774-15-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 4774-15-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 4774-15-6 ]
Downstream synthetic route of [ 4774-15-6 ]

[ 4774-15-6 ] Synthesis Path-Upstream 1~4

1
[ 4774-14-5 ]
[ 124-41-4 ]
[ 4774-15-6 ]

Yield	Reaction Conditions	Operation in experiment
98%	Heating / reflux	,6-Dimethoxypyrazine (V): A mixture of 1,6-dichloropiρerazine U (3.9g; 26 mmol) and freshly prepared sodium methoxide (62 mmol) in anhydrous methanol (50 ml) was refluxed overnight and the solvent was removed under reduced pressure. The residue was diluted to 100 ml with CH₂Cl₂ and the solution washed with water, brine and dried over anhydrous MgSO₄ and filtered off. The filtrate was evaporated under reduced pressure to <n="78"/>give pure 1,6-dimethoxypiperazine V (3.6 g; 98percent) as a colourless crystals. ¹HNMR (CDCl₃) 3.94 (s, 6H); 7.76 (s, 2H).

Reference： [1] Tetrahedron, 2009, vol. 65, # 43, p. 8891 - 8895
[2] Patent: WO2008/70908, 2008, A1, . Location in patent: Page/Page column 76-77
[3] Asian Journal of Chemistry, 2013, vol. 25, # 9, p. 4979 - 4982
[4] Journal of Heterocyclic Chemistry, 2016, vol. 53, # 5, p. 1386 - 1394
[5] Journal of the Chemical Society, 1965, p. 6681,6686
[6] Journal of Chemical Research, 2005, # 11, p. 747 - 749

2
[ 23229-25-6 ]
[ 124-41-4 ]
[ 4774-15-6 ]

Reference： [1] Journal of the American Chemical Society, 1949, vol. 71, p. 2043,2046
[2] Patent: CN105399690, 2016, A, . Location in patent: Paragraph 0004; 0007

3
[ 4774-14-5 ]
[ 124-41-4 ]
[ 4774-15-6 ]
[ 33332-30-8 ]

Reference： [1] Tetrahedron, 2009, vol. 65, # 43, p. 8891 - 8895

4
[ 4774-14-5 ]
[ 124-41-4 ]
[ 4774-15-6 ]
[ 33332-30-8 ]

Reference： [1] Tetrahedron, 2009, vol. 65, # 43, p. 8891 - 8895

[ 4774-15-6 ] Synthesis Path-Downstream 1~27

1
[ 23229-25-6 ]
[ 124-41-4 ]
[ 4774-15-6 ]

Yield	Reaction Conditions	Operation in experiment
	at 60℃;	the molar ratio of Sodiummethoxide and dibromopyrazine is 5:1 placed into three-necked flask with astirrer and a thermometer, added 500ml of Distilled water, start the mixer andwith speed of 200r / min it was stirredfor 10min; After the mixing the mixture was placed at reflux apparatus , heatedup to 60 C, refluxed for 2h, , the collected reflux liquid was put into abeaker then placed in an ice-water bath , at 4 C under ice the precipitatewas allowed to stand for 2h, filtered toobtain precipitate and spare after rotary evaporation drying; The massconcentration of concentrated sulfuric acid is 98% and after drying as mentioned above the precipitatemass ratio is 12: 1 were mixed andtogether poured into a beaker of 500mL, after stirred with a glass rod for10min placed on the shaker and Oscillating reaction for 2 h ,then againadded 50mL of nitric acid solution with a mass concentration of 95% , continues to oscillate the reaction for 20minto obtain a mixed solution; The ratio of the mixed liquid and ammonia water is1:5, the ammonia water was poured into the above mentioned mixed solution, placedthe reaction solution on a magnetic stirrer, with speed of 600r / min it was stirred for 10s , afterwards reduce speed to200r / min and continue to stir for 30min. After completion of the stirring,400ml of anhydrous ethanol added into the mixture solution, placed intoultrasonic vibration device, ultrasonic vibration reaction for 1h, thentransferred to a distillation apparatus, heated to 60 C, ethanol was removedby distillation,for drying used vacuum freeze-drying machine and after crushingof solid particles; Take 1g of the above mentioned solid particles and put into100ml of beaker , added 15ml of glacial acetic acid and 10ml of hydrogenperoxide with a mass concentration of 30%, water bath warmed to 40 C, andafter the 6hrs of reaction filtrated to obtain precipitate and dried to obtain 2,6-diamino-3,5-dinitro-1-oxidepyrazine.

Reference： [1]Journal of the American Chemical Society,1949,vol. 71,p. 2043,2046
[2]Patent: CN105399690,2016,A .Location in patent: Paragraph 0004; 0007

2
[ 4774-14-5 ]
[ 124-41-4 ]
[ 4774-15-6 ]

Yield	Reaction Conditions	Operation in experiment
98%	In methanol;Heating / reflux;	,6-Dimethoxypyrazine (V): A mixture of 1,6-dichloropirhoerazine U (3.9g; 26 mmol) and freshly prepared sodium methoxide (62 mmol) in anhydrous methanol (50 ml) was refluxed overnight and the solvent was removed under reduced pressure. The residue was diluted to 100 ml with CH2Cl2 and the solution washed with water, brine and dried over anhydrous MgSO4 and filtered off. The filtrate was evaporated under reduced pressure to <n="78"/>give pure 1,6-dimethoxypiperazine V (3.6 g; 98%) as a colourless crystals. 1HNMR (CDCl3) 3.94 (s, 6H); 7.76 (s, 2H).

Reference： [1]Tetrahedron,2009,vol. 65,p. 8891 - 8895
[2]Patent: WO2008/70908,2008,A1 .Location in patent: Page/Page column 76-77
[3]Asian Journal of Chemistry,2013,vol. 25,p. 4979 - 4982
[4]Journal of Heterocyclic Chemistry,2016,vol. 53,p. 1386 - 1394
[5]Journal of the Chemical Society,1965,p. 6681,6686
[6]Journal of Chemical Research,2005,p. 747 - 749

3
[ 4774-15-6 ]
[ 75-77-4 ]
[ 126327-76-2 ]

Reference： [1]Journal of Organic Chemistry,1990,vol. 55,p. 3410 - 3412

4
[ 4774-15-6 ]
[ 6919-61-5 ]
[ 135085-60-8 ]

Reference： [1]Journal of Heterocyclic Chemistry,1991,vol. 28,p. 765 - 768

5
[ 4774-15-6 ]
[ 100-52-7 ]
[ 126327-77-3 ]

Reference： [1]Journal of Organic Chemistry,1990,vol. 55,p. 3410 - 3412
[2]Journal of Organometallic Chemistry,1991,vol. 412,p. 301 - 310

6
[ 4774-15-6 ]
[ 135-02-4 ]
[ 136866-37-0 ]

Reference： [1]Journal of Organometallic Chemistry,1991,vol. 412,p. 301 - 310

7
[ 4774-15-6 ]
[ 93-61-8 ]
[ 136866-38-1 ]

Reference： [1]Journal of Organometallic Chemistry,1991,vol. 412,p. 301 - 310

8
[ 4774-15-6 ]
[ 611-74-5 ]
[ 135085-60-8 ]

Reference： [1]Journal of Organometallic Chemistry,1991,vol. 412,p. 301 - 310

9
[ 4774-15-6 ]
[ 74-88-4 ]
[ 90345-35-0 ]

Reference： [1]Journal of Organic Chemistry,1990,vol. 55,p. 3410 - 3412

10
[ 4774-15-6 ]
[ 136866-45-0 ]
[ 136866-46-1 ]

Reference： [1]Journal of Organometallic Chemistry,1991,vol. 412,p. 301 - 310

11
[ 4774-15-6 ]
[ 136866-32-5 ]

Reference： [1]Journal of Organometallic Chemistry,1991,vol. 412,p. 301 - 310

12
[ 4774-15-6 ]
[ 14233-64-8 ]
[ 181582-02-5 ]

Reference： [1]Tetrahedron Letters,1996,vol. 37,p. 5325 - 5328

14
[ 4774-15-6 ]
[ 4774-17-8 ]

Reference： [1]Journal of Chemical Research,2005,p. 747 - 749

15
[ 4774-15-6 ]
(2S,3R,4S,5R)-2-(3,5-Dimethoxy-pyrazin-2-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol [ No CAS ]

Reference： [1]Tetrahedron Letters,1996,vol. 37,p. 5325 - 5328

16
[ 4774-15-6 ]
[ 181581-97-5 ]

Reference： [1]Tetrahedron Letters,1996,vol. 37,p. 5325 - 5328

17
[ 4774-15-6 ]
[ 136866-48-3 ]

Reference： [1]Journal of Organometallic Chemistry,1991,vol. 412,p. 301 - 310

18
[ 4774-15-6 ]
[ 136866-42-7 ]

Reference： [1]Journal of Organometallic Chemistry,1991,vol. 412,p. 301 - 310

19
[ 4774-15-6 ]
[ 244261-85-6 ]

Yield	Reaction Conditions	Operation in experiment
		the molar ratio of Sodiummethoxide and dibromopyrazine is 5:1 placed into three-necked flask with astirrer and a thermometer, added 500ml of Distilled water, start the mixer andwith speed of 200r / min it was stirredfor 10min; After the mixing the mixture was placed at reflux apparatus , heatedup to 60 C, refluxed for 2h, , the collected reflux liquid was put into abeaker then placed in an ice-water bath , at 4 C under ice the precipitatewas allowed to stand for 2h, filtered toobtain precipitate and spare after rotary evaporation drying; The massconcentration of concentrated sulfuric acid is 98% and after drying as mentioned above the precipitatemass ratio is 12: 1 were mixed andtogether poured into a beaker of 500mL, after stirred with a glass rod for10min placed on the shaker and Oscillating reaction for 2 h ,then againadded 50mL of nitric acid solution with a mass concentration of 95% , continues to oscillate the reaction for 20minto obtain a mixed solution; The ratio of the mixed liquid and ammonia water is1:5, the ammonia water was poured into the above mentioned mixed solution, placedthe reaction solution on a magnetic stirrer, with speed of 600r / min it was stirred for 10s , afterwards reduce speed to200r / min and continue to stir for 30min. After completion of the stirring,400ml of anhydrous ethanol added into the mixture solution, placed intoultrasonic vibration device, ultrasonic vibration reaction for 1h, thentransferred to a distillation apparatus, heated to 60 C, ethanol was removedby distillation,for drying used vacuum freeze-drying machine and after crushingof solid particles; Take 1g of the above mentioned solid particles and put into100ml of beaker , added 15ml of glacial acetic acid and 10ml of hydrogenperoxide with a mass concentration of 30%, water bath warmed to 40 C, andafter the 6hrs of reaction filtrated to obtain precipitate and dried to obtain 2,6-diamino-3,5-dinitro-1-oxidepyrazine.

Reference： [1]Tetrahedron,2009,vol. 65,p. 8891 - 8895
[2]Asian Journal of Chemistry,2013,vol. 25,p. 4979 - 4982
[3]Patent: CN105399690,2016,A .Location in patent: Paragraph 0004; 0007

20
[ 4774-14-5 ]
[ 124-41-4 ]
[ 4774-15-6 ]
[ 33332-30-8 ]

Reference： [1]Tetrahedron,2009,vol. 65,p. 8891 - 8895

21
[ 4774-15-6 ]
1-oxo-2,6-dimethoxypyrazine [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2016,vol. 53,p. 1386 - 1394

22
[ 4774-15-6 ]
3,5-dimethoxy pyrazine-1-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With dihydrogen peroxide; acetic acid; at 55℃; for 4h;	20 ml of 30% hydrogen peroxide was slowly added to 20 ml of acetic acid at room temperature, and then 4 g of <strong>[4774-15-6]2,6-dimethoxypyrazine</strong> was added to the above oxidizing agent solution.After it is dissolved, the reaction system is heated to 55 C, and reacted for 4 hours; after the reaction is completed, the reaction system is cooled to room temperature and poured into ice water;The mixture was extracted 9 times with ethyl acetate.After the solid was filtered off, the filtrate was evaporated under reduced pressure to remove solvent.The white solid product <strong>[4774-15-6]2,6-dimethoxypyrazine</strong>-4-oxide was obtained in a yield of 68%.

Reference： [1]Patent: CN107266376,2017,A .Location in patent: Paragraph 0037; 0039; 0040; 0045; 0050; 0058; 0063; 0068

23
[ 4774-15-6 ]
[ 19194-55-9 ]
2-((3,5-dimethoxypyrazin-2-yl)methyl)isoindoline-1,3-dione [ No CAS ]
2,2'-((3,5-dimethoxypyrazine-2,6-diyl)bis(methylene))bis(isoindoline-1,3-dione) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
55%; 9%	With dilauryl peroxide; In 1,2-dichloro-ethane; for 6h;Inert atmosphere; Reflux;	General procedure: A magnetically stirred solution of xanthate (2.0 equiv) and pyrazine (1.0 equiv) in 1, 2-dichloroethane (1.0mmol/mL according to the xanthate) was refluxed for 15min under a flow of nitrogen. Then dilauroyl peroxide (DLP) was added portionwise (20mol % according to the xanthate) every hour until total consumption of one substrate. The reaction mixture was then cooled to room temperature and the solvent was evaporated under reduced pressure. Unless otherwise specified, the crude product was purified by flash chromatography on silica gel.
25%; 50%	With dilauryl peroxide; In 1,2-dichloro-ethane; for 6h;Inert atmosphere; Reflux;	General procedure: A magnetically stirred solution of xanthate (2.0 equiv) and pyrazine (1.0 equiv) in 1, 2-dichloroethane (1.0mmol/mL according to the xanthate) was refluxed for 15min under a flow of nitrogen. Then dilauroyl peroxide (DLP) was added portionwise (20mol % according to the xanthate) every hour until total consumption of one substrate. The reaction mixture was then cooled to room temperature and the solvent was evaporated under reduced pressure. Unless otherwise specified, the crude product was purified by flash chromatography on silica gel.

Reference： [1]Tetrahedron,2018,vol. 74,p. 5804 - 5817
[2]Tetrahedron,2018,vol. 74,p. 5804 - 5817

24
[ 4774-15-6 ]
[ 19194-55-9 ]
3-cyano-1-(6-((1,3-dioxoisoindolin-2-yl)methyl)-3,5-dimethoxypyrazin-2-yl)propyl acetate [ No CAS ]

Reference： [1]Tetrahedron,2018,vol. 74,p. 5804 - 5817

25
[ 4774-15-6 ]
[ 1885-14-9 ]
1-phenoxycarbonyl-2-phenyl-3,5-dimethoxy-1,2-dihydropyrazine [ No CAS ]

Reference： [1]Beilstein Journal of Organic Chemistry,2019,vol. 15,p. 72 - 78

26
[ 4774-15-6 ]
[ 1885-14-9 ]
C₁₃H₁₃N₂O₄⁽¹⁺⁾*Cl^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran; at 0℃; for 0.25h;Inert atmosphere;	General procedure: Representative procedure for the preparation of 1-phenoxycarbonyl-2-phenyl-3-methoxy-1,2-dihydropyrazine (3a). To a stirred solution of 2-methoxypyrazine (0.200 g, 1.816 mmol) inanhydrous THF (5 mL) was added phenylchloroformate (0.28 mL, 2.225 mmol) at 0 C andstirring was continued under nitrogen atmosphere until salt formation was completed (15 min, asdetermined by TLC on neutral alumina, EtOAc/hexanes 1:19). The reaction mixture was cooledto -41 C, a 1 M solution of phenylmagnesium bromide in THF (2.4 mL, 2.4 mmol) was addedand the mixture stirred until reaction completion (40 min, as determined by TLC on neutral SiO2,EtOAc/hexanes 1:9), and then quenched with 2 mL of aqueous 20% NH4OH/NH4Cl 1:1 (w/w).The mixture was extracted with dichloromethane (2 × 15 mL), dried over Na2SO4, andconcentrated in vacuo. Purification of the crude mixture by flash silica gel columnchromatography (0-15% EtOAc/hexanes) afforded 3a (0.488 g, 87%) as a white solid (3:2mixture of rotamers): mp: 81-82 C; 1H NMR (CDCl3, 500 MHz) delta 7.49-7.27 (m, 7H), 7.20 (t, J= 7.5 Hz, 1H), 7.12 (d, J = 8.0 Hz, 1H), 6.99 (d, J = 7.5 Hz, 1H), 6.67 and 6.63 (2d due torotamers, J = 5.5 Hz, 1H), 6.16 and 6.14 (2d due to rotamers, J = 5.0 Hz, 1H), 5.89 and 5.87 (2sdue to rotamers, 1H), 3.84 and 3.83 (2s due to rotamers, 3H); 13C NMR (CDCl3, 125 MHz) delta160.2, 160.0, 151.6, 151.5, 150.7, 150.4, 136.8, 135.9, 129.3, 128.8, 128.7, 128.6, 127.2, 126.6,125.9, 125.8, 121.3, 118.2, 118.1, 112.5, 111.8, 56.0, 54.6, 54.0, 53.9; HRMS (ESI) m/z calcdfor C18H17N2O3 [M + H]+ 309.12337, found 309.123554

Reference： [1]Beilstein Journal of Organic Chemistry,2019,vol. 15,p. 72 - 78

27
[ 4774-15-6 ]
[ 23229-25-6 ]

Yield	Reaction Conditions	Operation in experiment
93%	With phosphorus tribromide; phosphorus(V) oxybromide; at 80℃; for 1h;	Take <strong>[4774-15-6]2,6-dimethoxypyrazine</strong> (10g, 71.4mmol) into PBr3 (96g, 356mmol, 5eq) and POBr3 (102g, 356mmol, 5eq), stir at 80C for 1 hour, the reaction is complete. Slowly added to 2000g of crushed ice in batches, and extracted with 300ml of dichloromethane. The extract was dried over anhydrous sodium sulfate and concentrated to obtain 2,6-dibromopyrazine (15.8 g, yield 93%).
93%	With phosphorus tribromide; phosphorus(V) oxybromide; at 80℃; for 1h;	Take <strong>[4774-15-6]2,6-dimethoxypyrazine</strong> (10g, 71.4mmol) into PBr3 (96g, 356mmol, 5eq) and POBr3 (102g, 356mmol, 5eq), stir at 80C for 1 hour, the reaction is complete. Slowly added to 2000g of crushed ice in batches, and extracted with 300ml of dichloromethane. The extract was dried over anhydrous sodium sulfate and concentrated to obtain 2,6-dibromopyrazine (15.8 g, yield 93%).

Reference： [1]Patent: CN114057655,2022,A .Location in patent: Paragraph 0031-0033; 0038-0052
[2]Patent: CN114057655,2022,A .Location in patent: Paragraph 0031-0033; 0038-0052

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P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 4774-15-6 ] {[proInfo.proName]}

Quality Control of [ 4774-15-6 ]

Related Doc. of [ 4774-15-6 ]

Product Details of [ 4774-15-6 ]

Calculated chemistry of [ 4774-15-6 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 4774-15-6 ]

Application In Synthesis of [ 4774-15-6 ]

[ 4774-15-6 ] Synthesis Path-Upstream 1~4

[ 4774-15-6 ] Synthesis Path-Downstream 1~27

Related Functional Groups of [ 4774-15-6 ]

Ethers

Related Parent Nucleus of [ 4774-15-6 ]

Pyrazines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 4774-15-6 ]

Related Parent Nucleus of
[ 4774-15-6 ]