[ CAS No. 497-76-7 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 497-76-7
Chemical Structure| 497-76-7
Structure of 497-76-7

Quality Control of [ 497-76-7 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 497-76-7 ]

SDS

Product Details of [ 497-76-7 ]

CAS No. :497-76-7MDL No. :MFCD00016915
Formula :C12H16O7Boiling Point :561.6°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :272.25Pubchem ID :440936
Synonyms :

Computed Properties of [ 497-76-7 ]

TPSA : 120 H-Bond Acceptor Count : 7
XLogP3 : - H-Bond Donor Count : 5
SP3 : 0.50 Rotatable Bond Count : 3

Safety of [ 497-76-7 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 497-76-7 ]

  • Downstream synthetic route of [ 497-76-7 ]

[ 497-76-7 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 1668-09-3 ]
  • [ 123-31-9 ]
  • [ 497-76-7 ]
  • 2
  • [ 497-76-7 ]
  • [ 572-09-8 ]
  • 1-(tetra-O-acetyl-α-D-glucopyranosyloxy)-4-(tetra-O-acetyl-β-D-glucopyranosyloxy)-benzene [ No CAS ]
  • 3
  • [ 108-24-7 ]
  • [ 497-76-7 ]
  • [ 612802-12-7 ]
  • 4
  • [ 123-31-9 ]
  • glucoside synthetase from Bacillis subtilis K-531 [ No CAS ]
  • [ 497-76-7 ]
  • 5
  • [ 612802-12-7 ]
  • [ 497-76-7 ]
YieldReaction ConditionsOperation in experiment
96% With methanol; sodium methylate; at 25℃; for 2h; In a 100 ml reaction flask, add (1.21 g, 2.5 mmol)P-acetoxyphenyl-2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside 6,Add 36 ml of anhydrous methanol to dissolve, magnetically stir, add a catalytic amount of 0.06 g of sodium methoxide, react at 25 C for 2 hours, add acidic resin to neutralize to system pH = 7,The resin was recovered by filtration, and the filtrate was concentrated to dryness under reduced pressure.Beta-arbutinWhite solid 0.65 g,The yield was 96%.
  • 6
  • [ 439-03-2 ]
  • [ 497-76-7 ]
  • 7
  • [ 123-31-9 ]
  • [ 352432-46-3 ]
  • [ 497-76-7 ]
YieldReaction ConditionsOperation in experiment
With 2,6-di-tert-butyl-pyridine; tetra-(n-butyl)ammonium iodide; In acetonitrile; at 20℃; for 24h;Inert atmosphere; Molecular sieve; 11 g of tetra-n-butylammonium iodide, 4.4 g of hydroquinone, 5.7 g of 2,6-di-tert-butylpyridine was added to 100 ml Of acetonitrile in the stirring dissolved, then add 5 grams of 4A molecular sieve. Then, under an argon atmosphere, 11.5 g of 2,3,4,6-tetra-tri- Methylsilane-1-iodo-a-D-glucose in acetonitrile was added dropwise to the above reaction solution, and the mixture was stirred at room temperature for 24 hours. After completion of the reaction, the reaction solution was filtered, washed with water and trifluoroacetic acid was added thereto, followed by stirring at room temperature for 2 hours. At the end of the reaction the solvent was concentrated, Ethyl acetate was added to give a white solid which was filtered, Washed three times with ethyl acetate. The filter cake was dissolved in isopropanol to recrystallize, Dry, that is, white arbutin solid
  • 8
  • [ 108534-47-0 ]
  • [ 352432-46-3 ]
  • [ 497-76-7 ]
YieldReaction ConditionsOperation in experiment
With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; at 20℃; for 24h; A mixture of 22 g of tetra-n-butylammonium iodide, 3.6 g of 4-dimethyl-t-butylsiloxyphenol and 8.3 g of potassium carbonate were added to 100 ml of acetonitrile, and then 11.5 g of 2,3,4,6-tetra-trimethylsilyl-1- Iodo-a-D-glucose in acetonitrile was added to the above solution and stirred at room temperature for 24 hours. After the reaction, filter, wash and spin Dry solvent, the resulting oily liquid was dissolved in methanol, potassium fluoride was added to the solution, stirred at room temperature for 2 hours, and after the completion of the reaction Filtration and concentration of the solvent, adding ether precipitation, filtration, washing with ether three times, the filter cake dissolved in ethanol recrystallization, Filtered and dried to give a white alpha-arbutin solid.
  • 9
  • [ 3233-32-7 ]
  • [ 352432-46-3 ]
  • [ 497-76-7 ]
YieldReaction ConditionsOperation in experiment
With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0℃; for 36h;Inert atmosphere; 10 g of tetra-n-butylammonium iodide, 3 g of 4-acetoxyphenol, 5 ml of diisopropylethylamine was added to 100 ml Liter of methylene chloride, followed by stirring in an argon atmosphere, Will be 11.5 grams 2,3,4,6-tetra-O-trimethylsilyl-l-iodine -alpha-D-glucose in dichloromethane was added to the above solution at 0 C for 36 hours. After the reaction, filter and wash And the solvent was dried and the resulting oily liquid was dissolved in methanol. The cation exchange resin was added and stirred at room temperature for 2 hours. The reaction mixture After filtration, the solvent was concentrated, precipitated with ether, filtered, washed three times with ether, the filter cake was dissolved in ethanol, The crystals were filtered and washed to give a white alpha-arbutin solid.
  • 10
  • [ 103-16-2 ]
  • [ 352432-46-3 ]
  • [ 497-76-7 ]
YieldReaction ConditionsOperation in experiment
With quinoline; In toluene; at 80℃; for 10h;Inert atmosphere; Molecular sieve; 4 g of 4-benzyloxyphenol and 4 ml of quinoline were added to 100 ml of toluene and stirred and dissolved, and then 5 g 4A molecular sieves. Then, in an argon atmosphere, 11.5 g of 2,3,4,6-tetra-O-trimethylsilyl-1-iodo-a-D-glucose In toluene was added to the reaction solution and reacted at 80 C for 10 hours. After completion of the reaction, the mixture was filtered, washed with water and the solvent was dried The solution was dissolved in methanol, palladium on carbon was added, reacted in a hydrogen atmosphere for 2 hours, palladium on carbon was filtered, acetic acid was added to the solution, The mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was concentrated and acetone was added to give a white solid which was filtered, washed with acetone The filter cake was dissolved in a mixed solvent of water and acetone, and the mixture was filtered and dried to obtain a white arbutin solid.
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