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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 50-35-1 Chemical Structure| 50-35-1

Structure of Thalidomide
CAS No.: 50-35-1

Chemical Structure| 50-35-1

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Thalidomide targets to CRBN with IC50 of 8.5 nM. It can inhibit biosynthesis of TNF-α and has anti-angiogenic and immunosuppressive effects.

Synonyms: N-Phthaloylglutamimide; K17; Softenon Talimol

4.5 *For Research Use Only !

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Product Details of Thalidomide

CAS No. :50-35-1
Formula : C13H10N2O4
M.W : 258.23
SMILES Code : O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O
Synonyms :
N-Phthaloylglutamimide; K17; Softenon Talimol
MDL No. :MFCD00153873

Safety of Thalidomide

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H312-H361
Precautionary Statements:P201-P264-P280-P308+P313-P301+P310+P330-P302+P352+P312
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Target
  • TNF-α

  • E3 Ligase

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.87mL

0.77mL

0.39mL

19.36mL

3.87mL

1.94mL

38.73mL

7.75mL

3.87mL

References

[1]Fischer ES, Bohm K, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.

[2]D'Amato RJ, Loughnan MS, et al. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4082-5.

[3]Schumacher H, Blake DA, et al. A comparison of the teratogenic activity of thalidomide in rabbits and rats. J Pharmacol Exp Ther. 1968 Mar;160(1):189-200.

[4]Lu J, Palmer BD, et al. Thalidomide metabolites in mice and patients with multiple myeloma. Clin Cancer Res. 2003 May;9(5):1680-8.

[5]Thalidomide

[6]Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, Wong KK, Bradner JE, Kaelin WG Jr. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science. 2014 Jan 17;343(6168):305-9. doi: 10.1126/science.1244917. Epub 2013 Nov 29. PMID: 24292623; PMCID: PMC4070318.

[7]Lopez-Girona A, Mendy D, Ito T, Miller K, Gandhi AK, Kang J, Karasawa S, Carmel G, Jackson P, Abbasian M, Mahmoudi A, Cathers B, Rychak E, Gaidarova S, Chen R, Schafer PH, Handa H, Daniel TO, Evans JF, Chopra R. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia. 2012 Nov;26(11):2326-35. doi: 10.1038/leu.2012.119. Epub 2012 May 3. Erratum in: Leukemia. 2012 Nov;26(11):2445. PMID: 22552008; PMCID: PMC3496085.

[8]Haslett PA, Corral LG, Albert M, Kaplan G. Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset. J Exp Med. 1998 Jun 1;187(11):1885-92. doi: 10.1084/jem.187.11.1885. PMID: 9607928; PMCID: PMC2212313.

[9]D'Amato RJ, Loughnan MS, Flynn E, Folkman J. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4082-5. doi: 10.1073/pnas.91.9.4082. PMID: 7513432; PMCID: PMC43727.

[10]Sun X, Xu Y, Wang Y, Chen Q, Liu L, Bao Y. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203. doi: 10.12659/MSM.909977. PMID: 29763936; PMCID: PMC5978026.

 

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