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[ CAS No. 501-81-5 ] {[proInfo.proName]}

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Chemical Structure| 501-81-5
Chemical Structure| 501-81-5
Structure of 501-81-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 501-81-5 ]

CAS No. :501-81-5 MDL No. :MFCD00066302
Formula : C7H7NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :WGNUNYPERJMVRM-UHFFFAOYSA-N
M.W : 137.14 Pubchem ID :108
Synonyms :

Safety of [ 501-81-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 501-81-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 501-81-5 ]
  • Downstream synthetic route of [ 501-81-5 ]

[ 501-81-5 ] Synthesis Path-Upstream   1~27

  • 1
  • [ 501-81-5 ]
  • [ 3724-16-1 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 7, p. 2390 - 2394
[2] Patent: CN104557610, 2018, B, . Location in patent: Paragraph 0138; 0139; 0140; 0143; 0144
  • 2
  • [ 501-81-5 ]
  • [ 6293-56-7 ]
Reference: [1] Tetrahedron, 2015, vol. 71, # 39, p. 7107 - 7123
  • 3
  • [ 501-81-5 ]
  • [ 20173-24-4 ]
Reference: [1] Patent: CN104557610, 2018, B,
  • 4
  • [ 501-81-5 ]
  • [ 6443-85-2 ]
Reference: [1] Patent: CN104557610, 2018, B,
  • 5
  • [ 6419-36-9 ]
  • [ 501-81-5 ]
YieldReaction ConditionsOperation in experiment
100% With potassium hydroxide In ethanol (1)
To a suspension of 2-(pyridin-3-yl)acetic acid-hydrochloride (13.2g, 75.6mmol) in ethanol (100mL) was added a solution (150mL) of 0.5mol potassium hydroxide/ethanol, and the mixture was stirred well, then filtered to remove potassium chloride, concentrated, and dried to give 2-(pyridin-3-yl)acetic acid (10.6g, quantitative).
Reference: [1] Patent: EP1559716, 2005, A1, . Location in patent: Page/Page column 20
  • 6
  • [ 5423-64-3 ]
  • [ 501-81-5 ]
Reference: [1] Journal of the American Chemical Society, 1947, vol. 69, p. 1797
  • 7
  • [ 490-75-5 ]
  • [ 501-81-5 ]
Reference: [1] Helvetica Chimica Acta, 1941, vol. 24, p. 1471,1479
[2] Gazzetta Chimica Italiana, 1955, vol. 85, p. 1194,1198
  • 8
  • [ 6443-85-2 ]
  • [ 501-81-5 ]
Reference: [1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981, vol. 30, # 12, p. 2344 - 2347[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981, # 12, p. 2812 - 2815
  • 9
  • [ 626-55-1 ]
  • [ 501-81-5 ]
Reference: [1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981, vol. 30, # 12, p. 2344 - 2347[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981, # 12, p. 2812 - 2815
  • 10
  • [ 39931-77-6 ]
  • [ 501-81-5 ]
Reference: [1] Journal of the Chemical Society, 1958, p. 150,153
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981, vol. <B> 20, # 9, p. 793 - 795
[3] Patent: US6407120, 2002, B1, . Location in patent: Page column 23-24
  • 11
  • [ 39998-25-9 ]
  • [ 501-81-5 ]
Reference: [1] Helvetica Chimica Acta, 1941, vol. 24, p. 28 E, 33 E
  • 12
  • [ 350-03-8 ]
  • [ 501-81-5 ]
Reference: [1] Helvetica Chimica Acta, 1941, vol. 24, p. 28 E, 33 E
  • 13
  • [ 81335-71-9 ]
  • [ 501-81-5 ]
Reference: [1] Helvetica Chimica Acta, 1941, vol. 24, p. 1471,1479
  • 14
  • [ 807361-96-2 ]
  • [ 501-81-5 ]
Reference: [1] Helvetica Chimica Acta, 1941, vol. 24, p. 1471,1479
  • 15
  • [ 87052-73-1 ]
  • [ 501-81-5 ]
Reference: [1] Helvetica Chimica Acta, 1941, vol. 24, p. 1471,1479
  • 16
  • [ 7300-28-9 ]
  • [ 501-81-5 ]
Reference: [1] Recueil des Travaux Chimiques des Pays-Bas, 1951, vol. 70, p. 977,982
  • 17
  • [ 166411-29-6 ]
  • [ 501-81-5 ]
  • [ 187737-37-7 ]
Reference: [1] Tetrahedron Letters, 1989, vol. 30, # 13, p. 1699 - 1702
  • 18
  • [ 69713-27-5 ]
  • [ 501-81-5 ]
  • [ 115-11-7 ]
Reference: [1] Tetrahedron Letters, 1989, vol. 30, # 13, p. 1699 - 1702
  • 19
  • [ 54401-85-3 ]
  • [ 501-81-5 ]
  • [ 64-17-5 ]
Reference: [1] Tetrahedron Letters, 1995, vol. 36, # 17, p. 2963 - 2966
  • 20
  • [ 166411-29-6 ]
  • [ 501-81-5 ]
  • [ 67-63-0 ]
Reference: [1] Tetrahedron Letters, 1995, vol. 36, # 17, p. 2963 - 2966
  • 21
  • [ 166411-28-5 ]
  • [ 71-23-8 ]
  • [ 501-81-5 ]
Reference: [1] Tetrahedron Letters, 1995, vol. 36, # 17, p. 2963 - 2966
  • 22
  • [ 501-81-5 ]
  • [ 74-89-5 ]
  • [ 106271-65-2 ]
Reference: [1] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 2, p. 147 - 150
  • 23
  • [ 67-56-1 ]
  • [ 501-81-5 ]
  • [ 39998-25-9 ]
Reference: [1] ChemMedChem, 2017, vol. 12, # 20, p. 1693 - 1696
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 8, p. 1850 - 1864
[3] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 10, p. 3601 - 3616
[4] Phytochemistry (Elsevier), 1984, vol. 23, # 6, p. 1225 - 1228
  • 24
  • [ 186581-53-3 ]
  • [ 501-81-5 ]
  • [ 39998-25-9 ]
Reference: [1] Australian Journal of Chemistry, 1985, vol. 38, # 10, p. 1491 - 1497
  • 25
  • [ 501-81-5 ]
  • [ 19690-13-2 ]
Reference: [1] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 2, p. 147 - 150
  • 26
  • [ 501-81-5 ]
  • [ 6419-36-9 ]
Reference: [1] Patent: WO2009/50731, 2009, A2, . Location in patent: Page/Page column 15
[2] Patent: US2010/121066, 2010, A1, . Location in patent: Page/Page column 4
  • 27
  • [ 501-81-5 ]
  • [ 183483-09-2 ]
Reference: [1] European Journal of Medicinal Chemistry, 1999, vol. 34, # 5, p. 363 - 380
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Reason: Free-salt