77% |
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EXAMPLE 4 40 g of basic l-tetramisole are dissolved in a flask in 200 ml of dimethylsulphoxide, and a separately prepared solution of 5 g of potassium hydroxide in 10 ml of methanol is added under energetic agitation. The temperature is raised to 60, and the mixture is kept under agitation for 2 hours. It is cooled to below 10 C., 200 ml of water and 200 ml of chloroform are added, and the mixture well shaken. Two phases separate on leaving the mixture to stand. The chloroform phase is washed with 200 ml of water, and after separation the organic phase is precipitated with hydrogen chloride gas. The raceme tetramisole hydrochloride obtained in this manner weighs 36.2 g, the yield is 77% and the purity exceeds 98%. |
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A method according to claim 1, wherein the tablets comprise at least one agrochemically active compound selected from ... 1-(2-chloro-5-pyridylmethyl)-3,5-dimethyl-2-nitroimino-hexahydro-1,3,5-triazine, 1-(2-chloro-5-thiazolylmethyl)-3,5-dimethyl-2-nitroimino-hexahydro-1,3,5-triazine, 0,0-dimethyl O-3-methyl-4-(methylsulfinyl)-phenyl phosphorothioate, trans-1,4,5,6-tetrahydro-1-methyl-2-[2-(3-methyl-2-thienyl)-vinyl]-pyrimidine tartrate, (-)-(S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b] thiazole hydrochloride, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone, all-rac-1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-butan-2-ol, 2-p-chlorophenyl-2-(1H-1,2,4-triazol-1-yl-methyl)-hexane nitrile, ... |
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EXAMPLE 79 6-Phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole hydrochloride STR92 The product from Example 78 was converted to the desired 6-phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole hydrochloride and recrystallized as described in Example 75A. 168 g of substantially pure product, m.p. 255-6 C, was obtained. Examples 2, 38, 78 and 79 in sequence demonstrate a preferred sequence of processes to synthesise 6-phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole hydrochloride. |