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[ CAS No. 51322-75-9 ] {[proInfo.proName]}

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Chemical Structure| 51322-75-9
Chemical Structure| 51322-75-9
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Phelelisiwe S. Dube ; Dylan Hart ; Lesetja J. Legoabe , et al. DOI:

Abstract: Nitrothiazole derivatives have been reported to exhibit activity against aerobic, anaerobic, and microaerophilic bacteria. This activity profile makes the nitrothiazole compound class an ideal lead source against Mycobacterium tuberculosis, which flourishes in varied environments with different oxygen concentrations. In this work, we investigated six nitrothiazole derivatives for antitubercular activity. The compounds exhibited potent activity, with compounds 9 and 10 possessing an equipotent MIC90 value of 0.24 µM. The compounds were investigated for cytotoxicity against HEK293 cells and hemolysis against red blood cells, and they demonstrated no cytotoxicity nor hemolytic effects, suggesting they possess inherent antitubercular activity.

Keywords: nitrothiazole ; Mannich bases ; antitubercular activity ; tuberculosis ; Mycobacterium tuberculosis

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Product Details of [ 51322-75-9 ]

CAS No. :51322-75-9 MDL No. :MFCD00865192
Formula : C9H8ClN5S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 253.71 Pubchem ID :-
Synonyms :
Chemical Name :5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzo[c][1,2,5]thiadiazol-4-amine

Safety of [ 51322-75-9 ]

Signal Word:Warning Class:
Precautionary Statements:P201-P202-P264-P270-P280-P301+P312+P330-P308+P313-P220-P405-P501 UN#:
Hazard Statements:H302-H361 Packing Group:
GHS Pictogram:
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