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Chemistry
Heterocyclic Building Blocks
Pyridazines
Pyridazin-4-ylmethanamine
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Pyridazines
Amines

[ CAS No. 519020-42-9 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

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Chemical Structure| 519020-42-9
Chemical Structure| 519020-42-9
Structure of 519020-42-9 * Storage: {[proInfo.prStorage]}
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Quality Control of [ 519020-42-9 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
Alternatived Products of [ 519020-42-9 ]

Product Details of [ 519020-42-9 ]

CAS No. :519020-42-9 MDL No. :MFCD09263257
Formula : C5H7N3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 109.13 Pubchem ID :-
Synonyms :

Safety of [ 519020-42-9 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P301+P310 UN#:2811
Hazard Statements:H301 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 519020-42-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 519020-42-9 ]

[ 519020-42-9 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 519020-42-9 ]
  • [ 1380201-80-8 ]
  • C15H12ClN5O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;
Reference： [1]Location in patent: scheme or table Gentile, Gabriella; Merlo, Giancarlo; Pozzan, Alfonso; Bernasconi, Giovanni; Bax, Benjamin; Bamborough, Paul; Bridges, Angela; Carter, Paul; Neu, Margarete; Yao, Gang; Brough, Caroline; Cutler, Geoffrey; Coffin, Aaron; Belyanskaya, Svetlana [Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1989 - 1994]
  • 2
  • [ 519020-42-9 ]
  • [ 1392839-24-5 ]
  • [ 1392841-88-1 ]
YieldReaction ConditionsOperation in experiment
In ethanol for 16h; Reflux; 60 Example 607-Benzyl-l-cyano-4-hydroxy-8-oxo-7,8-dihydro- [2,7] naphthyridine-3-carboxylic acid(pyridazin-4-ylmethyl)-amide[0325] A mixture of 7-benzyl-l-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3- carboxylic acid methyl ester (25 mg, 0.075 mmol) and pyridazin-4-yl-methylamine (29 mg, 0.26 mmol) in EtOH (2 mL) was refluxed for 16 h. AcOH (0.1 mL) and water (2 mL) were added, and the mixture was allowed to come to r.t. The resulting suspension was filtered and the solid was washed with 5 mL of MeOH/H20 (1 :1). The solid was dried under vacuum to give 22 mg of the title compound. MS: (+) m/z 413.30 (M+l).
Reference： [1]Current Patent Assignee: FIBROGEN, INC. - WO2012/106472, 2012, A1 Location in patent: Page/Page column 119
  • 3
  • [ 354824-10-5 ]
  • [ 519020-42-9 ]
  • N-{1,4-dioxo-3-[(pyridazin-4-ylmethyl)amino]-1,4-dihydronaphthalen-2-yl}-N-(2-methoxyethyl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
In toluene at 45℃; for 4h;
Reference： [1]Ho, Si-Han Sherman; Ali, Azhar; Ng, Yi-Cheng; Lam, Kuen-Kuen Millie; Wang, Shu; Chan, Woon-Khiong; Chin, Tan-Min; Go, Mei-Lin [ChemMedChem, 2016, p. 1944 - 1955]
  • 4
  • [ 257640-86-1 ]
  • [ 519020-42-9 ]
  • 9-fluoro-7-hydroxy-3-methyl-5-oxo-N-(pyridazin-4-ylmethyl)-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% In N,N-dimethyl-formamide at 100℃; for 0.5h; Sealed tube; Microwave irradiation;
Reference： [1]Hu, Ziwei; Banothu, Janardhan; Beesu, Mallesh; Gustafson, Collin J.; Brush, Michael J. H.; Trautman, Kathryn L.; Salyer, Alex C. D.; Pathakumari, Balaji; David, Sunil A. [ACS Medicinal Chemistry Letters, 2019, vol. 10, # 1, p. 132 - 136]
  • 5
  • [ 519020-42-9 ]
  • 4-({7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-6-yl}methyl)benzoic acid [ No CAS ]
  • 4-({7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-6-yl}methyl)-N-[(pyridazin-4-yl)methyl]benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In 1,4-dioxane; N,N-dimethyl-formamide at 20℃; for 3h; 14 4-({7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-6-yl}methyl)benzamide General procedure: To a solution of intermediate 14a 4-({7-Amino-5-methyl-[1 ,2,5]oxadiazolo[3,4- b]pyridin-6-yl}nnethyl)benzoic acid (50 mg; 0.18 mmol), N,N-diisopropylethylamine (71 pl0.39 mmol) and 0-(7-Azabenzothazol-1 -yl)-N,N,N',N'-tetramethyluronium hexafluoro-phosphate (73.5 mg; 0.19 mmol) in 0.5 ml_ N,N-dimethylformamide is added after 5 minutes ammonia (0.5 M solution in dioxane 0.70 ml0.35 mmol). The reaction is stirred for three hours at room temperature and purified by reverse phase chromatography (modifier: ammonium hydroxide)Yield: 20.4 mg (41 % of theory)Mass spectrometry (ESI+): m/z = 284 [M+H]+HPLC (Method 5): Retention time = 0.46 min.
Reference： [1]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG - WO2019/149657, 2019, A1 Location in patent: Page/Page column 170; 177

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