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[ CAS No. 52604-30-5 ] {[proInfo.proName]}

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Chemical Structure| 52604-30-5
Chemical Structure| 52604-30-5
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CAS No. :52604-30-5 MDL No. :MFCD01540097
Formula : C16H12O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 252.27 Pubchem ID :-
Synonyms :

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52604-30-5 ]

[ 52604-30-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 504-15-4 ]
  • [ 94-02-0 ]
  • [ 52604-30-5 ]
YieldReaction ConditionsOperation in experiment
97% With copper(ll) bromide at 80℃; for 0.333333h; neat (no solvent);
88% With nanosilica molybdic acid 2 In neat (no solvent) at 80℃; for 0.333333h; Green chemistry; General procedure for the synthesis of coumarinderivatives 5a-o General procedure: In a general experimental procedure, β-ketoester 3(1 mmol) was added to a mixture of substituted phenol4 (1 mmol) and SMA NPs 2 (5 mol%) in a solvent-freetube. The reaction mixture was stirred in a preheated oilbath (80 °C). After the completion of the reaction, the precipitateobtained was extracted with ethyl acetate, washedwith water (3 × 10 ml) and dried to obtain the product.The remaining insoluble solid catalyst in aqueous phasewas separated by filtration, washed with ethyl acetate
85% With Ag supported on the hydroxyapatite-core-shell magnetic γ-Fe2O3 nanoparticles In neat (no solvent) at 80℃; for 0.7h; Green chemistry; 2.2. General procedure for the Pechmann condensation General procedure: In a round bottom flask, g-Fe2O3HAp-Ag NPs (10 mg) were added to the mixture of the phenolic compound (1 mmol) and ethyl acetoacetate (1 mmol) at 80 C and the reaction mixture stirred for the appropriate time (Table 3). The progress of the reaction was monitored by TLC (eluent, n-hexane:ethyl acetate, 4:1) analysis. Upon completion of the reaction, EtOH was added to the reaction mixture and the g-Fe2O3HAp-Ag NPs were separated with an external magnet. The solvent was then removed under reduced pressure and the resulting product was purified by recrystallization using ethanol. The coumarin derivatives were obtained in good to excellent isolated yields (83%-96%).
80% With silica gel supported zirconyl chloride octahydrate at 90℃; for 1.16667h;
66% With organosulfonic acid functionalized silica-coated magnetic nanoparticles at 120℃; for 5h; Green chemistry; General Synthesis of Coumarins by Pechmann Reaction: General procedure: Amixture of phenol (2 mmol), β-keto ester (2 mmol), and catalyst(0.3 mol%) was heated and magnetically stirred at 120 °C for theappropriate time under solvent-free conditions (Table 4). Inmany cases, the coumarins separated out as a solid mass on theinner wall of the flask at the end of the reaction. Upon completionof the reaction (monitored by TLC), the reaction mixturewas cooled to room temperature, hot EtOH (5 mL) was added,and the mixture was stirred for 15 min. The catalyst wasremoved from the reaction mixture by magnetic separation.The ethanolic solution was evaporated, the residue was pouredonto crushed ice, and the resulting crude product was filteredoff and recrystallized from ethanol to afford pure coumarin.
22% In trifluoroacetic acid at 100℃; for 0.5h; microwave irradiation;

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