Name: 52959-28-1|Dimethyl 4,6-dihydroxyisophthalate|97%
Brand: Ambeed
SKU: A1150560
Price: 27.0 USD
Availability: InStock
Rating: 98 (40 reviews)

1
[ 186581-53-3 ]
[ 19829-74-4 ]
[ 52959-28-1 ]

Reference： [1]Proceedings - Indian Academy of Sciences, Section A,1951,vol. 34,p. 368,378
[2]Recueil des Travaux Chimiques des Pays-Bas,1950,vol. 69,p. 1021,1024

2
[ 67-56-1 ]
[ 19829-74-4 ]
[ 52959-28-1 ]

Yield	Reaction Conditions	Operation in experiment
67%	With thionyl chloride; at 0℃;Reflux;	To a solution of 15 (700.0 mg, 3.36 mmol) in MeOH (18 ml), SOCI2(1 .63 g, 1 .22 ml, 13.43 mmol, 4.0 eq) was added dropwise at 0 C. When the addition was completed the reaction mixture was refluxed overnight. The resulting suspension was cooled down to 0 C and then filtered, washing with cold methanol, to obtain 16 as white crystals (506.2 mg, 2.24 mmol, 67 % yield).1H and13C NMR in agreement with literature reference [Eur. J. Org. Chem. 2013, 36, 8135-8144].
	With sulfuric acid; for 48h;Reflux;	A solution of acid (3.18 g) and concentrated H2SO4 (4 mL) in methanol (64 mL) was heated under reflux for 2 days. The product was obtained upon cooling and was filtered off and washed with a small amount of MeOH to give pure methyl ester.
	With sulfuric acid;	FIG. 5A shows the synthesis of 2,4-dihydroxy-5-nitrobenzoic acid from the commercially available 2,4-dihydroxybenzoic acid. The acid is then esterified and alkylated in high yields. The alkylation reaction is quite general, since methyl, ally, iso-butyl, octyl, and decyl bromides all have resulted in corresponding products with high yields (>95percent).

Reference： [1]Chemical Communications,2012,vol. 48,p. 2228 - 2230
[2]Journal of the American Chemical Society,2000,vol. 122,p. 2635 - 2644
[3]European Journal of Organic Chemistry,2013,p. 8135 - 8144
[4]Angewandte Chemie - International Edition,2015,vol. 54,p. 11117 - 11121
Angew. Chem.,2016,vol. 127,p. 11269 - 11273,5
[5]Patent: WO2018/130713,2018,A1 .Location in patent: Page/Page column 50
[6]Journal of the Chemical Society,1957,p. 1833,1834
[7]Journal of Organic Chemistry,2005,vol. 70,p. 10660 - 10669
[8]Patent: US9155738,2015,B2 .Location in patent: Page/Page column 358
[9]Patent: CN109305926,2019,A .Location in patent: Paragraph 0048
[10]Patent: WO2019/99922,2019,A1 .Location in patent: Paragraph 0035; 0129

3
[ 19829-74-4 ]
[ 77-78-1 ]
[ 52959-28-1 ]

Reference： [1],1932,vol. 6,p. 96

4
[ 52959-28-1 ]
C₂₁H₃₅ClN₂ [ No CAS ]
4,6-Bis-[N'-(4-dodecyl-phenyl)-N,N-dimethyl-carbamimidoyloxy]-isophthalic acid dimethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
93%	With sodium hydride In tetrahydrofuran

Reference： [1]Marsh, Andrew; Nolen, Ernest G.; Gardinier, Kevin M.; Lehn, Jean-Marie [Tetrahedron Letters, 1994, vol. 35, # 3, p. 397 - 400]

5
[ 108-46-3 ]
[ 52959-28-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 4 h / 200 °C / Schlenk technique 2: sulfuric acid / 15 h / Reflux
	Multi-step reaction with 2 steps 1: 4 h / 200 °C / Inert atmosphere 2: 6 h / Acidic conditions; Reflux; Inert atmosphere

Reference： [1]Marsh, Andrew; Nolen, Ernest G.; Gardinier, Kevin M.; Lehn, Jean-Marie [Tetrahedron Letters, 1994, vol. 35, # 3, p. 397 - 400]
[2]Montarnal, Damien; Delbosc, Nicolas; Chamignon, Cécile; Virolleaud, Marie-Alice; Luo, Yingdong; Hawker, Craig J.; Drockenmuller, Eric; Bernard, Julien [Angewandte Chemie - International Edition, 2015, vol. 54, # 38, p. 11117 - 11121][Angew. Chem., 2016, vol. 127, # 38, p. 11269 - 11273]
[3]Aksimentiev, Aleksei; Chen, Feng; Joshi, Himanshu; Roy, Arundhati; Shen, Jie; Ye, Ruijuan; Zeng, Huaqiang [Angewandte Chemie - International Edition, 2020, vol. 59, # 12, p. 4806 - 4813][Angew. Chem., 2020, vol. 132, # 12, p. 4836 - 4843,8]

6
[ 52959-28-1 ]
[ 77-78-1 ]
[ 14965-05-0 ]

Yield	Reaction Conditions	Operation in experiment
93%	With potassium carbonate In acetone for 72h; Heating;
	With potassium carbonate In acetone

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]
[2]Madeja-Kotkowska,Z. [Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1974, vol. 22, p. 365 - 375]

7
[ 6946-10-7 ]
[ 922-67-8 ]
[ 52959-28-1 ]

Yield	Reaction Conditions	Operation in experiment
18%	With sodium hydride In tetrahydrofuran at -10℃; for 2h;

Reference： [1]Covarrubias-Zuniga, Adrian; Maldonado, Luis A.; Rios-Barrios, Eduardo; Gonzalez-Lucas, Armando [Synthetic Communications, 1998, vol. 28, # 18, p. 3461 - 3469]

8
[ 111-83-1 ]
[ 52959-28-1 ]
[ 267897-57-4 ]

Yield	Reaction Conditions	Operation in experiment
99%	With potassium carbonate In methanol; N,N-dimethyl-formamide at 100℃; for 16h;
88%	With potassium carbonate In N,N-dimethyl-formamide for 48h; Heating;
88%	With potassium carbonate In methanol; N,N-dimethyl-formamide at 100℃; for 48h;

88%	With potassium carbonate In methanol; N,N-dimethyl-formamide at 100℃; for 48h;
	With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere;

Reference： [1]Montarnal, Damien; Delbosc, Nicolas; Chamignon, Cécile; Virolleaud, Marie-Alice; Luo, Yingdong; Hawker, Craig J.; Drockenmuller, Eric; Bernard, Julien [Angewandte Chemie - International Edition, 2015, vol. 54, # 38, p. 11117 - 11121][Angew. Chem., 2016, vol. 127, # 38, p. 11269 - 11273]
[2]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]
[3]Zeng, Huaqiang; Miller, Rebecca S.; Flowers II, Robert A.; Gong, Bing [Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2635 - 2644]
[4]Zeng; Ickes; Flowers II; Gong [Journal of Organic Chemistry, 2001, vol. 66, # 10, p. 3574 - 3583]
[5]Aksimentiev, Aleksei; Chen, Feng; Joshi, Himanshu; Roy, Arundhati; Shen, Jie; Ye, Ruijuan; Zeng, Huaqiang [Angewandte Chemie - International Edition, 2020, vol. 59, # 12, p. 4806 - 4813][Angew. Chem., 2020, vol. 132, # 12, p. 4836 - 4843,8]

9
[ 78-77-3 ]
[ 52959-28-1 ]
[ 231954-15-7 ]

Yield	Reaction Conditions	Operation in experiment
85%	With potassium carbonate In N,N-dimethyl-formamide for 48h; Heating;

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

10
toluene-4-sulfonic acid 2-(3-methylbutoxy)propyl ester [ No CAS ]
[ 52959-28-1 ]
4,6-bis[2-(3-methylbutoxy)propoxy]isophthalic acid dimethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
54.5%	With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 48h;

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

11
[ 52959-28-1 ]
[ 62921-74-8 ]
[ 874210-29-4 ]

Yield	Reaction Conditions	Operation in experiment
85.4%	With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 48h;
70%	With potassium carbonate In N,N-dimethyl-formamide at 80℃;

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]
[2]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]

12
[ 52959-28-1 ]
[ 83948-53-2 ]
[ 874210-32-9 ]

Yield	Reaction Conditions	Operation in experiment
86.6%	With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 90℃; for 36h;

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

13
[ 52959-28-1 ]
[ 110661-91-1 ]
[ 874210-33-0 ]

Yield	Reaction Conditions	Operation in experiment
85.1%	With potassium carbonate; potassium iodide In N,N-dimethyl-formamide for 48h; Heating;

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

14
[ 358-23-6 ]
[ 52959-28-1 ]
[ 890705-76-7 ]

Yield	Reaction Conditions	Operation in experiment
79%	With pyridine In dichloromethane at 20℃; for 0.666667h;

Reference： [1]Jouvenot, Damien; Glazer, Edith C.; Tor, Yitzhak [Organic Letters, 2006, vol. 8, # 10, p. 1987 - 1990]

15
[ 52959-28-1 ]
[ 26690-80-2 ]
[ 898809-04-6 ]

Yield	Reaction Conditions	Operation in experiment
78%	With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 20℃; for 48h;

Reference： [1]Choi, Sungwook; Clements, Dylan J.; Pophristic, Vojislava; Ivanov, Ivaylo; Vemparala, Satyavani; Bennett, Joel S.; Klein, Michael L.; Winkler, Jeffrey D.; DeGrado, William F. [Angewandte Chemie - International Edition, 2005, vol. 44, # 41, p. 6685 - 6689]

16
[ 915184-71-3 ]
[ 52959-28-1 ]
dimethyl 4,6-bis(2-(isopentyloxy)ethoxy)isophthalate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere;
	With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 72h;

Reference： [1]Wei, Xiaoxi; Zhang, Guoqing; Shen, Yi; Zhong, Yulong; Liu, Rui; Yang, Na; Al-Mkhaizim, Fayez Y.; Kline, Mark A.; He, Lan; Li, Minfeng; Lu, Zhong-Lin; Shao, Zhifeng; Gong, Bing [Journal of the American Chemical Society, 2016, vol. 138, # 8, p. 2749 - 2754]
[2]Zhang, Aimin; Ferguson, Joseph S.; Yamato, Kazuhiro; Zheng, Chong; Gong, Bing [Organic Letters, 2006, vol. 8, # 22, p. 5117 - 5120]

17
[ 52959-28-1 ]
[ 109-73-9 ]
N,N'-dibutyl-4,6-dihydroxy-isophthalamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
22%	In N,N-dimethyl-formamide at 110℃; for 48h;

Reference： [1]Santacroce, Paul V.; Davis, Jeffery T.; Light, Mark E.; Gale, Philip A.; Iglesias-Sanchez, Jose Carlos; Prados, Pilar; Quesada, Roberto [Journal of the American Chemical Society, 2007, vol. 129, # 7, p. 1886 - 1887]

18
[ 52959-28-1 ]
[ 54176-27-1 ]
[ 939374-70-6 ]

Yield	Reaction Conditions	Operation in experiment
82%	With potassium carbonate In acetone for 36h; Heating;

Reference： [1]Li, Chuang; Wang, Gui-Tao; Yi, Hui-Ping; Jiang, Xi-Kui; Li, Zhan-Ting; Wang, Ren-Xiao [Organic Letters, 2007, vol. 9, # 9, p. 1797 - 1800]

19
[ 52959-28-1 ]
[ 874210-38-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 70 percent / K₂CO₃ / dimethylformamide / 80 °C 2: 3.5 g / NaOH / methanol; H₂O / 20 °C
	Multi-step reaction with 2 steps 1: 85.4 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 68.9 percent / NaOH / H₂O; methanol / 20 °C

Reference： [1]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]
[2]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

20
[ 52959-28-1 ]
[ 936347-09-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 70 percent / K₂CO₃ / dimethylformamide / 80 °C 2: NaOH / methanol; H₂O / 20 °C 3: 0.95 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C

Reference： [1]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]

21
[ 52959-28-1 ]
C₂₆H₄₀N₂O₁₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 70 percent / K₂CO₃ / dimethylformamide / 80 °C 2: NaOH / methanol; H₂O / 20 °C 3: 0.95 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C 4: NaOH / methanol; H₂O / 20 °C

Reference： [1]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]

22
[ 52959-28-1 ]
[ 936352-81-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: 70 percent / K₂CO₃ / dimethylformamide / 80 °C 2: NaOH / methanol; H₂O / 20 °C 3: 0.95 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C 4: NaOH / methanol; H₂O / 20 °C 5: 1.3 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C

Reference： [1]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]

23
[ 52959-28-1 ]
C₅₄H₇₈N₄O₂₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: 70 percent / K₂CO₃ / dimethylformamide / 80 °C 2: NaOH / methanol; H₂O / 20 °C 3: 0.95 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C 4: NaOH / methanol; H₂O / 20 °C 5: 1.3 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C 6: NaOH / methanol; H₂O / 20 °C

Reference： [1]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]

24
[ 52959-28-1 ]
[ 936354-31-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: 70 percent / K₂CO₃ / dimethylformamide / 80 °C 2: NaOH / methanol; H₂O / 20 °C 3: 0.95 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C 4: NaOH / methanol; H₂O / 20 °C 5: 1.3 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C

Reference： [1]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]

25
[ 52959-28-1 ]
C₅₄H₈₀N₆O₂₂*2C₂HF₃O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: 70 percent / K₂CO₃ / dimethylformamide / 80 °C 2: NaOH / methanol; H₂O / 20 °C 3: 0.95 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C 4: NaOH / methanol; H₂O / 20 °C 5: 1.3 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C 6: TFA / CH₂Cl₂ / 20 °C

Reference： [1]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]

26
[ 52959-28-1 ]
C₄₄H₅₅NO₁₁S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 70 percent / K₂CO₃ / dimethylformamide / 80 °C 2: 3.5 g / NaOH / methanol; H₂O / 20 °C 3: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C

Reference： [1]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]

27
[ 52959-28-1 ]
[ 936354-38-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 70 percent / K₂CO₃ / dimethylformamide / 80 °C 2: 3.5 g / NaOH / methanol; H₂O / 20 °C 3: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-hydroxybenzotriazole / CH₂Cl₂ / 20 h / 0 - 20 °C 4: NaOH / methanol

Reference： [1]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]

28
[ 52959-28-1 ]
[ 492465-50-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 70 percent / K₂CO₃ / dimethylformamide / 80 °C 2: NaOH / methanol; H₂O / 20 °C
	Multi-step reaction with 2 steps 1: 85.4 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 91 percent / KOH / H₂O / 3 h / 80 °C

Reference： [1]Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12628 - 12629]
[2]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

29
[ 52959-28-1 ]
[ 939374-74-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 82 percent / potassium carbonate / acetone / 36 h / Heating 2: 89 percent / hydrated hydrazine / methanol / 0.5 h / 20 °C 3: 69 percent / EDCI; DMAP / CH₂Cl₂ / 3 h / 20 °C

Reference： [1]Li, Chuang; Wang, Gui-Tao; Yi, Hui-Ping; Jiang, Xi-Kui; Li, Zhan-Ting; Wang, Ren-Xiao [Organic Letters, 2007, vol. 9, # 9, p. 1797 - 1800]

30
[ 52959-28-1 ]
[ 939374-75-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 82 percent / potassium carbonate / acetone / 36 h / Heating 2: 89 percent / hydrated hydrazine / methanol / 0.5 h / 20 °C 3: 69 percent / EDCI; DMAP / CH₂Cl₂ / 3 h / 20 °C 4: 95 percent / potassium hydroxide / methanol; H₂O / 3 h / Heating

Reference： [1]Li, Chuang; Wang, Gui-Tao; Yi, Hui-Ping; Jiang, Xi-Kui; Li, Zhan-Ting; Wang, Ren-Xiao [Organic Letters, 2007, vol. 9, # 9, p. 1797 - 1800]

31
[ 52959-28-1 ]
[ 939374-76-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 82 percent / potassium carbonate / acetone / 36 h / Heating 2: 89 percent / hydrated hydrazine / methanol / 0.5 h / 20 °C 3: 62 percent / EDCI / CH₂Cl₂ / 4 h / 20 °C

Reference： [1]Li, Chuang; Wang, Gui-Tao; Yi, Hui-Ping; Jiang, Xi-Kui; Li, Zhan-Ting; Wang, Ren-Xiao [Organic Letters, 2007, vol. 9, # 9, p. 1797 - 1800]

32
[ 52959-28-1 ]
[ 939374-71-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 82 percent / potassium carbonate / acetone / 36 h / Heating 2: 89 percent / hydrated hydrazine / methanol / 0.5 h / 20 °C

Reference： [1]Li, Chuang; Wang, Gui-Tao; Yi, Hui-Ping; Jiang, Xi-Kui; Li, Zhan-Ting; Wang, Ren-Xiao [Organic Letters, 2007, vol. 9, # 9, p. 1797 - 1800]

33
[ 52959-28-1 ]
[ 939374-72-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 82 percent / potassium carbonate / acetone / 36 h / Heating 2: 89 percent / hydrated hydrazine / methanol / 0.5 h / 20 °C 3: 36 percent / DMAP; EDCI / CH₂Cl₂ / 5 h / 20 °C

Reference： [1]Li, Chuang; Wang, Gui-Tao; Yi, Hui-Ping; Jiang, Xi-Kui; Li, Zhan-Ting; Wang, Ren-Xiao [Organic Letters, 2007, vol. 9, # 9, p. 1797 - 1800]

34
[ 52959-28-1 ]
C₃₀H₄₉N₅O₁₀ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 82 percent / potassium carbonate / acetone / 36 h / Heating 2: 89 percent / hydrated hydrazine / methanol / 0.5 h / 20 °C 3: 38 percent / DMAP; EDCI / CH₂Cl₂ / 5 h / 20 °C

Reference： [1]Li, Chuang; Wang, Gui-Tao; Yi, Hui-Ping; Jiang, Xi-Kui; Li, Zhan-Ting; Wang, Ren-Xiao [Organic Letters, 2007, vol. 9, # 9, p. 1797 - 1800]

35
[ 52959-28-1 ]
4,6-bis[2-(3-methyl-butoxy)-ethoxy]-isophthalic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: anhydrous K₂CO₃ / dimethylformamide / 72 h / 100 °C 2: 4.26 g / NaOH / methanol / 2 h / Heating

Reference： [1]Zhang, Aimin; Ferguson, Joseph S.; Yamato, Kazuhiro; Zheng, Chong; Gong, Bing [Organic Letters, 2006, vol. 8, # 22, p. 5117 - 5120]

36
[ 52959-28-1 ]
{2-[5-(2-tert-butoxycarbonylamino-ethoxy)-2,4-bis-chlorocarbonyl-phenoxy]-ethyl}-carbamic acid tert-butyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 78 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 48 h / 20 °C 2: 84 percent / lithium hydroxide / methanol; tetrahydrofuran; H₂O / 24 h 3: oxalyl chloride; pyridine / tetrahydrofuran; dimethylformamide / 0.75 h

Reference： [1]Choi, Sungwook; Clements, Dylan J.; Pophristic, Vojislava; Ivanov, Ivaylo; Vemparala, Satyavani; Bennett, Joel S.; Klein, Michael L.; Winkler, Jeffrey D.; DeGrado, William F. [Angewandte Chemie - International Edition, 2005, vol. 44, # 41, p. 6685 - 6689]

37
[ 52959-28-1 ]
[ 872675-27-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 78 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 48 h / 20 °C 2: 84 percent / lithium hydroxide / methanol; tetrahydrofuran; H₂O / 24 h

Reference： [1]Choi, Sungwook; Clements, Dylan J.; Pophristic, Vojislava; Ivanov, Ivaylo; Vemparala, Satyavani; Bennett, Joel S.; Klein, Michael L.; Winkler, Jeffrey D.; DeGrado, William F. [Angewandte Chemie - International Edition, 2005, vol. 44, # 41, p. 6685 - 6689]

38
[ 52959-28-1 ]
[ 890705-79-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 79 percent / pyridine / CH₂Cl₂ / 0.67 h / 20 °C 2: 88 percent / triethylamine; CuI / Pd(dppf)Cl₂ / tetrahydrofuran / 45 °C 3: 56 percent / ammonia / ethanol / 140 °C 4: 42 percent / phosphorus oxybromide; potassium carbonate / acetonitrile / 5 h / Heating

Reference： [1]Jouvenot, Damien; Glazer, Edith C.; Tor, Yitzhak [Organic Letters, 2006, vol. 8, # 10, p. 1987 - 1990]

39
[ 52959-28-1 ]
[ 890705-78-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 79 percent / pyridine / CH₂Cl₂ / 0.67 h / 20 °C 2: 88 percent / triethylamine; CuI / Pd(dppf)Cl₂ / tetrahydrofuran / 45 °C 3: 56 percent / ammonia / ethanol / 140 °C

Reference： [1]Jouvenot, Damien; Glazer, Edith C.; Tor, Yitzhak [Organic Letters, 2006, vol. 8, # 10, p. 1987 - 1990]

40
[ 52959-28-1 ]
[ 890705-74-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: 79 percent / pyridine / CH₂Cl₂ / 0.67 h / 20 °C 2.1: 88 percent / triethylamine; CuI / Pd(dppf)Cl₂ / tetrahydrofuran / 45 °C 3.1: 56 percent / ammonia / ethanol / 140 °C 4.1: 42 percent / phosphorus oxybromide; potassium carbonate / acetonitrile / 5 h / Heating 5.1: n-butyllithium; ZnCl₂ / hexane; tetrahydrofuran / -78 - 20 °C 5.2: 80 percent / Pd(P(C₆H₅)3)4 / tetrahydrofuran; hexane / Heating

Reference： [1]Jouvenot, Damien; Glazer, Edith C.; Tor, Yitzhak [Organic Letters, 2006, vol. 8, # 10, p. 1987 - 1990]

41
[ 52959-28-1 ]
[ 890705-77-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 79 percent / pyridine / CH₂Cl₂ / 0.67 h / 20 °C 2: 88 percent / triethylamine; CuI / Pd(dppf)Cl₂ / tetrahydrofuran / 45 °C

Reference： [1]Jouvenot, Damien; Glazer, Edith C.; Tor, Yitzhak [Organic Letters, 2006, vol. 8, # 10, p. 1987 - 1990]

42
[ 52959-28-1 ]
4,6-di(isobutoxy)isophthalic acid monomethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 85 percent / K₂CO₃ / dimethylformamide / 48 h / Heating 2: 62.6 percent / NaOH / H₂O; tetrahydrofuran / 12 h / 20 °C
	Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C 2: potassium hydroxide / methanol; dimethyl sulfoxide / 8 h / 100 °C

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]
[2]Bie, Fusheng; Wang, Ying; Shang, Jie; Gallagher, Nolan M.; Jiang, Hua [European Journal of Organic Chemistry, 2013, # 36, p. 8135 - 8144]

43
[ 52959-28-1 ]
[ 874210-36-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 85 percent / K₂CO₃ / dimethylformamide / 48 h / Heating 2: 91 percent / KOH / H₂O; methanol / Heating

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

44
[ 52959-28-1 ]
4,6-bis-(3-carboxy-propoxy)-isophthalic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 85.1 percent / K₂CO₃; KI / dimethylformamide / 48 h / Heating 2: 10 percent / lithium hydroxide monohydrate / methanol / 20 °C

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

45
[ 52959-28-1 ]
5-Chlorocarbonyl-2,4-bis-[(S)-2-(3-methyl-butoxy)-propoxy]-benzoic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 54.5 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 68.6 percent / KOH / H₂O; methanol / 3 h / Heating 3: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

46
[ 52959-28-1 ]
2,4-bis((S)-2-(isopentyloxy)propoxy)-5-(methoxycarbonyl)benzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 54.5 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 68.6 percent / KOH / H₂O; methanol / 3 h / Heating

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

47
[ 52959-28-1 ]
4,6-Bis-[(S)-2-(3-methyl-butoxy)-propoxy]-isophthaloyl dichloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 54.5 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 83.3 percent / KOH / H₂O; methanol / Heating 3: oxalyl chloride; DMF / CH₂Cl₂

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

48
[ 52959-28-1 ]
4,6-bis[2-(3-methylbutoxy)propoxy]isophthalic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 54.5 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 83.3 percent / KOH / H₂O; methanol / Heating

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

49
[ 52959-28-1 ]
4,6-bis-(3-tert-butoxycarbonyl-propoxy)-isophthalic acid monomethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 85.1 percent / K₂CO₃; KI / dimethylformamide / 48 h / Heating 2: 72 percent / lithium hydroxide monohydrate / methanol / 20 °C

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

50
[ 52959-28-1 ]
4,6-bis[3-(tert-butoxycarbonyl)propoxy]isophthalic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 85.1 percent / K₂CO₃; KI / dimethylformamide / 48 h / Heating 2: 5 percent / lithium hydroxide monohydrate / methanol / 20 °C
	Multi-step reaction with 2 steps 1: 85.1 percent / K₂CO₃; KI / dimethylformamide / 48 h / Heating 2: 15 percent / lithium hydroxide monohydrate / H₂O; methanol / 15 h / 20 °C

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]
[2]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

51
[ 52959-28-1 ]
4,6-bis[3-(tert-butoxycarbonylamino)propoxy]isophthalic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 86.6 percent / K₂CO₃; KI / dimethylformamide / 36 h / 90 °C 2: 93.9 percent / NaOH / H₂O; methanol; tetrahydrofuran / 1 h / Heating

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

52
[ 52959-28-1 ]
N,N'-bis-(5-amino-2,4-dimethoxy-phenyl)-4,6-bis-[2-(3-methyl-butoxy)-propoxy]-isophthalamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: 54.5 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 83.3 percent / KOH / H₂O; methanol / Heating 3: oxalyl chloride; DMF / CH₂Cl₂ 4: triethylamine / CH₂Cl₂ / 20 °C 5: H₂ / Pd/C / ethanol; CHCl₃ / 4 h / 48 °C / 0.03 Torr

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

53
[ 52959-28-1 ]
N,N'-bis-(2,4-dimethoxy-5-nitro-phenyl)-4,6-bis-[2-(3-methyl-butoxy)-propoxy]-isophthalamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 54.5 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 83.3 percent / KOH / H₂O; methanol / Heating 3: oxalyl chloride; DMF / CH₂Cl₂ 4: triethylamine / CH₂Cl₂ / 20 °C

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

54
[ 52959-28-1 ]
C₅₆H₈₂Cl₂N₂O₁₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: 54.5 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 68.6 percent / KOH / H₂O; methanol / 3 h / Heating 3: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating 4: 2.18 g / triethylamine / CH₂Cl₂ / 6 h / 20 °C 5: 86.2 percent / KOH / H₂O / 3 h / Heating 6: oxalyl chloride; DMF / CH₂Cl₂

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

55
[ 52959-28-1 ]
C₅₈H₈₈N₂O₁₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 54.5 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 68.6 percent / KOH / H₂O; methanol / 3 h / Heating 3: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating 4: 2.18 g / triethylamine / CH₂Cl₂ / 6 h / 20 °C

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

56
[ 52959-28-1 ]
C₅₆H₈₄N₂O₁₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: 54.5 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 68.6 percent / KOH / H₂O; methanol / 3 h / Heating 3: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating 4: 2.18 g / triethylamine / CH₂Cl₂ / 6 h / 20 °C 5: 86.2 percent / KOH / H₂O / 3 h / Heating

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

57
[ 52959-28-1 ]
C₇₂H₁₀₀N₆O₂₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 7 steps 1: 54.5 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C 2: 68.6 percent / KOH / H₂O; methanol / 3 h / Heating 3: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating 4: 2.18 g / triethylamine / CH₂Cl₂ / 6 h / 20 °C 5: 86.2 percent / KOH / H₂O / 3 h / Heating 6: oxalyl chloride; DMF / CH₂Cl₂ 7: 0.20 g / triethylamine / CH₂Cl₂ / 20 °C

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

58
[ 52959-28-1 ]
[ 7168-99-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 93 percent / K₂CO₃ / acetone / 72 h / Heating 2: 92.1 percent / NaOH / methanol; H₂O / 4 h / Heating

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]

59
[ 52959-28-1 ]
[ 267897-58-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 88 percent / K₂CO₃ / dimethylformamide / 48 h / Heating 2: 96 percent / KOH / tetrahydrofuran; H₂O / 2 h / Heating
	Multi-step reaction with 2 steps 1: 88 percent / K₂CO₃ / dimethylformamide; methanol / 48 h / 100 °C 2: 93 percent / aq. NaOH / methanol / 0.67 h / Heating

Reference： [1]Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing [Journal of Organic Chemistry, 2005, vol. 70, # 26, p. 10660 - 10669]
[2]Zeng, Huaqiang; Miller, Rebecca S.; Flowers II, Robert A.; Gong, Bing [Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2635 - 2644]

60
[ 52959-28-1 ]
[ 345625-94-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 88 percent / K₂CO₃ / methanol; dimethylformamide / 48 h / 100 °C 2: 61 percent / KOH / dimethylsulfoxide; methanol / 3 h / 130 °C
	Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide; methanol / 16 h / 100 °C 2: sodium hydroxide / methanol / 48 h / 80 °C

Reference： [1]Zeng; Ickes; Flowers II; Gong [Journal of Organic Chemistry, 2001, vol. 66, # 10, p. 3574 - 3583]
[2]Montarnal, Damien; Delbosc, Nicolas; Chamignon, Cécile; Virolleaud, Marie-Alice; Luo, Yingdong; Hawker, Craig J.; Drockenmuller, Eric; Bernard, Julien [Angewandte Chemie - International Edition, 2015, vol. 54, # 38, p. 11117 - 11121][Angew. Chem., 2016, vol. 127, # 38, p. 11269 - 11273]

61
[ 52959-28-1 ]
[ 267897-60-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 88 percent / K₂CO₃ / dimethylformamide; methanol / 48 h / 100 °C 2: 93 percent / aq. NaOH / methanol / 0.67 h / Heating 3: 69 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide*HCl; 1-hydroxybenzotriazole; Et₃N / dimethylformamide / 6 h 4: 90 percent / aq. NaOH / methanol / 0.67 h / Heating

Reference： [1]Zeng, Huaqiang; Miller, Rebecca S.; Flowers II, Robert A.; Gong, Bing [Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2635 - 2644]

62
[ 52959-28-1 ]
[ 267897-59-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 88 percent / K₂CO₃ / dimethylformamide; methanol / 48 h / 100 °C 2: 93 percent / aq. NaOH / methanol / 0.67 h / Heating 3: 69 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide*HCl; 1-hydroxybenzotriazole; Et₃N / dimethylformamide / 6 h

Reference： [1]Zeng, Huaqiang; Miller, Rebecca S.; Flowers II, Robert A.; Gong, Bing [Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2635 - 2644]

63
[ 52959-28-1 ]
N,N'-bis[(((3'-((hexylamino)carbonyl)-4-(octyloxy)phenyl)amino)carbonyl)methyl]-4,6-bis(octyloxy)-1,3-benzenedicarboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: 88 percent / K₂CO₃ / dimethylformamide; methanol / 48 h / 100 °C 2: 93 percent / aq. NaOH / methanol / 0.67 h / Heating 3: 69 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimideHCl; 1-hydroxybenzotriazole; Et₃N / dimethylformamide / 6 h 4: 90 percent / aq. NaOH / methanol / 0.67 h / Heating 5: 79 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimideHCl; 1-hydroxybenzotriazole / dimethylformamide / 6 h / 20 °C

Reference： [1]Zeng, Huaqiang; Miller, Rebecca S.; Flowers II, Robert A.; Gong, Bing [Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2635 - 2644]

64
[ 108-46-3 ]
[ 52959-28-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 45 percent / 3 h / 210 °C 2: 90 percent / conc. H₂SO₄ / 48 h / Heating

Reference： [1]Zeng, Huaqiang; Miller, Rebecca S.; Flowers II, Robert A.; Gong, Bing [Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2635 - 2644]

65
[ 15540-79-1 ]
[ 52959-28-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: NaNO₂; aqueous H₂SO₄ / Erwaermen des Reaktionsgemisches mit wss. H₂SO₄ 2: diethyl ether; ethanol

Reference： [1]Beyerman; Alberda [Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 1021,1024]

66
C₂₁H₄₁ClN₂O₂ [ No CAS ]
[ 52959-28-1 ]
[ 1031691-56-1 ]

Yield	Reaction Conditions	Operation in experiment
76%	With potassium carbonate; potassium iodide In acetone for 7h; Heating;

Reference： [1]Cai, Wei; Wang, Gui-Tao; Xu, Yun-Xiang; Jiang, Xi-Kui; Li, Zhan-Ting [Journal of the American Chemical Society, 2008, vol. 130, # 22, p. 6936 - 6937]

67
[ 1031691-45-8 ]
[ 52959-28-1 ]
[ 1031691-51-6 ]

Yield	Reaction Conditions	Operation in experiment
81%	Stage #1: dimethyl 4,6-dihydroxyisophthalate With potassium carbonate In acetone for 0.5h; Stage #2: 2-(2-(dioctylamino)-2-oxoethyl-amino)-2-oxoethyl chloride With potassium iodide In acetone for 7h; Heating; Further stages.;

Reference： [1]Cai, Wei; Wang, Gui-Tao; Xu, Yun-Xiang; Jiang, Xi-Kui; Li, Zhan-Ting [Journal of the American Chemical Society, 2008, vol. 130, # 22, p. 6936 - 6937]

68
[ 112-29-8 ]
[ 52959-28-1 ]
[ 1052717-00-6 ]

Yield	Reaction Conditions	Operation in experiment
87%	With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere;

Reference： [1]Cai, Wei; Wang, Gui-Tao; Du, Ping; Wang, Ren-Xiao; Jiang, Xi-Kui; Li, Zhan-Ting [Journal of the American Chemical Society, 2008, vol. 130, # 40, p. 13450 - 13459]

69
[ 52959-28-1 ]
[ 192378-93-1 ]
[ 1156504-65-2 ]

Yield	Reaction Conditions	Operation in experiment
35%	With tetrabutylammomium bromide; potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 168h; Inert atmosphere;

Reference： [1]Zhu, Kelong; He, Jiuming; Li, Shijun; Liu, Ming; Wang, Feng; Zhang, Mingming; Abliz, Zeper; Yang, Hai-Bo; Li, Ning; Huang, Feihe [Journal of Organic Chemistry, 2009, vol. 74, # 10, p. 3905 - 3912]

70
[ 52959-28-1 ]
[ 109-73-9 ]
[ 1031691-43-6 ]

Yield	Reaction Conditions	Operation in experiment
45%	In N,N-dimethyl-formamide at 75℃; for 7h;

Reference： [1]Location in patent: experimental part You, Li-Yan; Wang, Gui-Tao; Jiang, Xi-Kui; Li, Zhan-Ting [Tetrahedron, 2009, vol. 65, # 45, p. 9494 - 9504]

71
[ 52959-28-1 ]
[ 1359296-24-4 ]
[ 1359296-32-4 ]

Yield	Reaction Conditions	Operation in experiment
76.4%	With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h;

Reference： [1]Wu, Xiangxiang; Liang, Guoxing; Ji, Gang; Fun, Hoong-Kun; He, Lan; Gong, Bing [Chemical Communications, 2012, vol. 48, # 16, p. 2228 - 2230]

72
[ 52959-28-1 ]
[ 107-82-4 ]
[ 1359296-31-3 ]

Yield	Reaction Conditions	Operation in experiment
70%	With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h;

Reference： [1]Wu, Xiangxiang; Liang, Guoxing; Ji, Gang; Fun, Hoong-Kun; He, Lan; Gong, Bing [Chemical Communications, 2012, vol. 48, # 16, p. 2228 - 2230]

73
[ 52959-28-1 ]
[ 87549-18-6 ]
[ 1454693-35-6 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: dimethyl 4,6-dihydroxyisophthalate; 2-hexyldecyl-4-methylbenzene sulfonate With potassium carbonate In N,N-dimethyl-formamide Stage #2: With potassium hydroxide In methanol; water Stage #3: With hydrogenchloride In methanol; water

Reference： [1]Hu, Jinchuan; Chen, Long; Ren, Yi; Deng, Pengchi; Li, Xiaowei; Wang, Youjia; Jia, Yiming; Luo, Jian; Yang, Xinshi; Feng, Wen; Yuan, Lihua [Organic Letters, 2013, vol. 15, # 18, p. 4670 - 4673]

74
[ 52959-28-1 ]
[ 87549-18-6 ]
[ 1454693-36-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide 2: oxalyl dichloride / dichloromethane

Reference： [1]Hu, Jinchuan; Chen, Long; Ren, Yi; Deng, Pengchi; Li, Xiaowei; Wang, Youjia; Jia, Yiming; Luo, Jian; Yang, Xinshi; Feng, Wen; Yuan, Lihua [Organic Letters, 2013, vol. 15, # 18, p. 4670 - 4673]

75
[ 52959-28-1 ]
[ 1373944-94-5 ]
[ 1454693-40-3 ]

Yield	Reaction Conditions	Operation in experiment
43 mg	With triethylamine In dichloromethane at -20℃; Inert atmosphere;

Reference： [1]Hu, Jinchuan; Chen, Long; Ren, Yi; Deng, Pengchi; Li, Xiaowei; Wang, Youjia; Jia, Yiming; Luo, Jian; Yang, Xinshi; Feng, Wen; Yuan, Lihua [Organic Letters, 2013, vol. 15, # 18, p. 4670 - 4673]

76
[ 52959-28-1 ]
[ 1454709-91-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h 1.2: 72 h / 100 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

77
[ 52959-28-1 ]
[ 1454709-92-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h 1.2: 48 h / 80 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

78
[ 52959-28-1 ]
[ 1454709-94-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h 1.2: 72 h / 100 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C
	Multi-step reaction with 2 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h 1.2: 72 h / 100 °C 2.1: potassium hydroxide; water / methanol / 24 h / 80 °C

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]
[2]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

79
[ 52959-28-1 ]
[ 1454710-02-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h 1.2: 72 h / 100 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C 4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 5.1: potassium hydroxide; water / methanol / 72 h / Reflux

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

80
[ 52959-28-1 ]
[ 1454710-03-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h 1.2: 48 h / 80 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C 4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 5.1: potassium hydroxide; water / methanol / 72 h / Reflux

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

81
[ 52959-28-1 ]
[ 1454709-98-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h 1.2: 72 h / 100 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C 4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

82
[ 52959-28-1 ]
[ 1454709-99-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h 1.2: 48 h / 80 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C 4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

83
[ 52959-28-1 ]
[ 1454710-10-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h 1.2: 72 h / 100 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h 4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere 5.1: trifluoroacetic acid / 20 °C
	Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h 1.2: 72 h / 100 °C 2.1: potassium hydroxide; water / methanol / 24 h / 80 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h 4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere 5.1: trifluoroacetic acid / 20 °C

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]
[2]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

84
[ 52959-28-1 ]
[ 1454710-06-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h 1.2: 72 h / 100 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h 4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere
	Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h 1.2: 72 h / 100 °C 2.1: potassium hydroxide; water / methanol / 24 h / 80 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h 4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]
[2]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

85
[ 52959-28-1 ]
[ 1454710-11-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h 1.2: 48 h / 80 °C 2.1: potassium hydroxide; water / methanol / 24 h / 80 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h 4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere 5.1: trifluoroacetic acid / 20 °C

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

86
[ 52959-28-1 ]
[ 1454710-07-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h 1.2: 48 h / 80 °C 2.1: potassium hydroxide; water / methanol / 24 h / 80 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h 4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

87
[ 52959-28-1 ]
C₁₉H₂₇ClO₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h 1.2: 72 h / 100 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

88
[ 52959-28-1 ]
C₁₇H₂₃ClO₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h 1.2: 48 h / 80 °C 2.1: potassium hydroxide; water / methanol / 24 h / 60 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

Reference： [1]Kline, Mark; Wei, Xiaoxi; Gong, Bing [Organic Letters, 2013, vol. 15, # 18, p. 4762 - 4765]

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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CAS No. :	52959-28-1	MDL No. :	MFCD20133532
Formula :	C₁₀H₁₀O₆	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	CMTOZSKJCALTLF-UHFFFAOYSA-N
M.W :	226.18	Pubchem ID :	14927440
Synonyms :

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 52959-28-1 ] {[proInfo.proName]}

Quality Control of [ 52959-28-1 ]

Related Doc. of [ 52959-28-1 ]

Product Details of [ 52959-28-1 ]

Safety of [ 52959-28-1 ]

Application In Synthesis of [ 52959-28-1 ]

[ 52959-28-1 ] Synthesis Path-Downstream 1~88

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry