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[ CAS No. 532924-25-7 ]

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Product Details of [ 532924-25-7 ]

CAS No. :	532924-25-7	MDL No. :	MFCD10696660
Formula :	C₆H₅BClNO₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	201.37 g/mol	Pubchem ID :	-
Synonyms :

Safety of [ 532924-25-7 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330	UN#:
Hazard Statements:	H302-H315-H319	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 532924-25-7 ]

Downstream synthetic route of [ 532924-25-7 ]

[ 532924-25-7 ] Synthesis Path-Downstream 1~15

1
[ 352-34-1 ]
[ 532924-25-7 ]
[ 1221425-66-6 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate In 1,2-dimethoxyethane; water at 60℃; for 2h; Inert atmosphere;	23 (Comparative Example 23); 5-Chloro-4 ' -fluorobiphenyl-2-amineTo water (2 mL) and dimethoxyethane (20 mL) , 5-chloro-2- nitrophenylboronic acid (3.27 g, 16.4 mmol), 1-fluoro-4-iodobenzene (3.65 g, 16.4 mmol), tetrakis (triphenylphosphine) palladium (0.95 g, 0.82 mmol) and potassium carbonate (6.81 g, 49.3 mmol) were added, and the mixture was stirred under a nitrogen atmosphere at 600C for 2 hours. After the reaction, the reaction mixture was cooled to room temperature and ethyl acetate (30 mL) was added. After the organic phase was washed with water (30 mL) and saturated brine (20 mL) , it was dried with sodium sulfate. The solvent was distilled off under reduced pressure to give 5-chloro-4 ' -fluoro-2- nitrobiphenyl as a crude product. The obtained compound was used for the subsequent reaction without further purification.

Reference： [1]Current Patent Assignee: EXELIXIS INC - WO2010/42626, 2010, A1 Location in patent: Page/Page column 46

2
[ 532924-25-7 ]
methyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-phenylpropanoate [ No CAS ]
methyl 2-(4-(5-chloro-2-nitrophenyl)-2-oxopyridin-1(2H)-yl)-3-phenylpropanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ In ethanol; toluene at 110℃; for 0.166667h; Microwave irradiation;	i-2.B Preparation of methyl 2-(4-(5-chloro-2-nitrophenyl)-2-oxopyridin-1(2H)-yl)-3-phenylpropanoate (i-2b) A degassed suspension of 1-lb (500 mg, 1.49 mmol), (5-chloro-2-nitrophenyl)boronicacid (329 mg, 1.64 mmol), potassium carbonate (206 mg, 1.49 mmol), and [1,1’-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (163 mg, 0.22 mmol) in EtOH:toluene (10 mL of a 4:1 mixture) was heated in a microwave reactor to 110 °C for 10 min. After cooling to rt, the reaction mixture was diluted with EtOAc and filtered through a colunm of Celite, which was rinsed with additional portions of EtOAc. The combined organics were dried(Na2SO4), filtered and concentrated, and the resulting crude residue was purified by flash chromatography on silica gel (gradient elution; 0%-30% EtOAc/hexanes as eluent) to afford the title compound as a white solid. m/z (ES) 413 (MH)+.

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2014/160592, 2014, A2 Location in patent: Page/Page column 41

3
[ 532924-25-7 ]
2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-phenylpropanoic acid [ No CAS ]
2-(4-(5-chloro-2-nitrophenyl)-2-oxopyridin-1(2H)-yl)-3-phenylpropanoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; sodium phosphate In 1-methyl-pyrrolidin-2-one at 90℃; for 16h;	i-2.A Preparation of 2-(4-(5-chloro-2-nitrophenyl)-2-oxopyridin-1(2H)-yl)-3-phenylpropanoic acid (i-2a) A degassed suspension of i-ic (100 mg, 0.3 10 mmol), (5-chloro-2-nitrophenyl)boronic acid (94 mg, 0.466 mmol), potassium phosphate, tribasic (0.78 mL of a 1M aq. solution, 0.778 mmol), and 1,1 ‘-bis(di-tert-butylphosphino)ferrocenepalladium dichloride (20 mg, 0.031 mmol)in NMP (2.6 mL) was heated to 90 °C. After 16 h, the reaction mixture was cooled to rt, and partitioned between EtOAc and water. The layers were separated, the aq. layer was acidified with 1M HC1 and extracted with EtOAc. The combined organics were washed with water and brine, dried (MgSO4), filtered and concentrated to afford the title compound i-2a as a crude brown solid. m/z (ES) 399 (MH)+.

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2014/160592, 2014, A2 Location in patent: Page/Page column 40; 41

4
[ 532924-25-7 ]
tert-butyl 4-(2-(5-bromopyridin-2-yl)-3-phenylpropanamido)benzoate [ No CAS ]
tert-butyl 4-(2-(5-(5-chloro-2-nitrophenyl)pyridin-2-yl)-3-phenylpropanamido)benzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ In tetrahydrofuran; water at 100℃; for 1h; Microwave irradiation; Sealed tube; Inert atmosphere;	1.3; 2.3 Step 3. fert-Butyl 4-(2-(5 -(5 -chloro-2-nitrophenyl)pyridin-2-yl)-3 -phenylpropanamido) benzoate(l-C) Step 3. fert-Butyl 4-(2-(5 -(5 -chloro-2-nitrophenyl)pyridin-2-yl)-3 -phenylpropanamido) benzoate(l-C) A mixture of tert-butyl 4-(2-(5-bromopyridin-2-yl)-3 -phenylpropanamido) benzoate (1-B) (0.475 g, 0.987 mmol), (5-chloro-2-nitrophenyl)boronic acid (0.397 g, 1.973 mmol), PdCl2(dppf)-CH2Cl2 adduct (0.16 g, 0.197 mmol) in THF(5 mL) was added potassium phosphate tribasic aqueous solution (2 mL, 4 mmol, 2M) in a microwave tube. The tube was sealed, degassed and refilled with N2. The mixture was heated at 100°C by microwave for 1 hour. The reaction mixture was diluted with water, extracted with EtOAc, and the organic layers were combined and washed with brine and dried over Na2S04. Solvent was removed in vacuo. The residue was purified by column chromatography on silica gel, eluting with EtOAc/hexane to give product 1-C. 1H NMR (500 MHz, CDC13) δ: 1.66 (9H, s), 3.32 (1 H, dd), 3.60 (1 H, dd), 4.10 (1 H, m), 7.05 (2 H, d), 7.10-7.24 (4H,m), 7.42 (1 H, d), 7.58-7.63 (4H, m), 7.95 (2 H, d), 8.03 (1 H, d), 8.59 (1 H, s), 10.00 (1 H, s).

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2015/183709, 2015, A1 Location in patent: Page/Page column 34

5
[ 532924-25-7 ]
2-(1-(5-bromopyridin-2-yl)-2-phenylethyl)-5-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazole [ No CAS ]
2-(1-(5-(5-chloro-2-nitrophenyl)pyridin-2-yl)-2-phenylethyl)-5-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate In tetrahydrofuran; water at 100℃; for 1h; Inert atmosphere; Microwave irradiation;	7.4 Step 4. 2-(l -(5-(5-chloro-2-nitrophenyl)pyridin-2-yl)-2-phenylethyl)-5-fluoro- 1 -((2- (trimethylsilyl)ethoxy)methyl)-lH-benzo[dlimidazole) (3-D): A reaction mixture of 2-(l-(5- Bromopyridin-2-yl)-2-phenylethyl)-5 -fluoro- 1 -((2-(trimethylsilyl)ethoxy)methyl) - 1 H- benzo[d]imidazole (3-C) (150 mg, 0.28 mmol), PdCl2(dppf) (62.5 mg, 0.085 mmol), (5-chloro- 2-nitrophenyl)boronic acid (86 mg, 0.427 mmol) and potassium phosphate tribasic aq. solution (0.57 ml, 1.14 mmol, 2M) in THF (2 ml) was degassed and refilled with N2. It was heated at 100°C for 1 hour by microwave. The reaction mixture was diluted with water, extracted with EtOAc, the organic was washed with brine, dried over Na2S04. Solvent was removed in vacuo. The residue was purified by column chromatography on silica gel, eluting with EtOAc/hexane to give the product (3-D). 1H NMR (500 MHz, CDC13) δ: -0.097 (9H, s), 0.79-0.64 (2H, m), 3.30- 3.18 (2H, m), 3.62 (1H, m), 3.89 (1H, m), 4.90 (1H, m), 5.27 (1H, dd), 5.45 (1H, dd), 7.03 (1H, m), 7.23-7.12 (6H, m), 7.31 (1H, m), 7.36 (1H, m), 7.60-7.49 (3H, m), 7.79 (1H, m), 7.96 (1H, d,) 8.46 (1H, s).

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2016/18701, 2016, A1 Location in patent: Page/Page column 35; 36

6
[ 532924-25-7 ]
2-(1-(5-bromopyridin-2-yl)-2-phenylethyl)-5-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazole [ No CAS ]
4-chloro-2-(6-(1-(5-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-2-phenylethyl)pyridin-3-yl)aniline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 1 h / 100 °C / Inert atmosphere; Microwave irradiation 2: tin(II) chloride dihdyrate; ethanol / ethyl acetate / 3 h / 50 °C

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2016/18701, 2016, A1

7
[ 2730-62-3 ]
[ 532924-25-7 ]
[ 357274-88-5 ]

Yield	Reaction Conditions	Operation in experiment
76%	With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-pyrrole In 1,4-dioxane; water at -100 - 100℃; for 5h; Autoclave;	25 General procedure: (3a, 5a) General procedure: The reaction was carried out in an autoclave containing a 10 mL Teflon reaction tube. Pd(PPh3)2Cl2 (1 mol %), B (2 mol %) and a magnetic stir bar were placed in the tube, followed by addition of arylboronic acid (1 mmol), NaHCO3 (2 mmol), 1,4-dioxane (2 mL) and water (0.5 mL). the tube was capped with a stopper. The autoclave was cooled down to -100 °C by liquid nitrogen, and 2-chloro-3,3,3-trifluoroprop-1-ene (2, 18 mmol) was added to the reaction. Finally the autoclave was heated in an oil bath at 100 °C for 5 h. After the reaction, the autoclave was then cooled to room temperature and vented to discharge the excessive 2,3,3,3-tetrafluoropropylene carefully. Water (60 mL) was added, and the product was extracted with dichloromethane (3*15 mL). The organic layers were washed with brine (30 mL), dried over Na2SO4, and the organic solvent was evaporated by a rotary evaporator under atmospheric pressure. The crude product was purified by column chromatography (silica gel, petroleum ether/ethyl acetate as eluents).

Reference： [1]Li, Yang; Zhao, Bo; Dai, Kun; Tu, Dong-Huai; Wang, Bo; Wang, Yao-Yu; Liu, Zhao-Tie; Liu, Zhong-Wen; Lu, Jian [Tetrahedron, 2016, vol. 72, # 37, p. 5684 - 5690]

8
[ 504424-70-8 ]
[ 532924-25-7 ]
5-(5-chloro-2-nitrophenyl)-1-phenyl-1H-indole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate In tetrahydrofuran; water at 40 - 80℃; for 12h; Inert atmosphere;	2.2 Synthesis of 5-(5-chloro-2-nitrophenyl)-1-phenyl-1H-indole Nitrogen gas stream under the above obtained from 5-bromo-1-phenyl-1H-indole (20 g, 73.49 mmol), 5-chloro-2-nitrophenylboronic acid (17.78g, 88.18 mmol), K 2 CO 3 (30.47 g, 220.47 mmol) and THF / H2O into the (400ml / 100 ml) was stirred. In 40 °C Pd(PPh3)4 into the (2.54 g, 2.204mmol) it was stirred under reflux at 80 °C for 12 hours.After completion of the reaction extracted with dichloromethane, and the organic layer is MgSO4was filtered off and dried in a vacuum.The filtered organic layer was evaporated under reduced pressure to a back by column chromatography the desired compound 5- (5-chloro-2- nitrophenyl) -1-phenyl-1H-indole (18 g,yield: 72%) was obtained.
72%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate In tetrahydrofuran; water at 40 - 80℃; for 12h; Inert atmosphere;	1.1 Synthesis of 5-(5-chloro-2-nitrophenyl)-1-phenyl-1H-indole A stream of nitrogen under 5-bromo-1-phenyl-1H-indole (20 g, 73.49 mmol), 5-chloro-2-nitrophenylboronic acid (17.78g, 88.18 mmol), K2CO3 (30.47 g, 220.47 mmol) and THF/H2O (400ml / 100 ml) were put into a stirred. At 40 into the Pd (PPh3) 4 (2.54 g, 2.204mmol) was stirred under reflux at 80 for 12 hours. After completion of the reaction, which was then extracted with dichloromethane. The organic layer was dried over MgSO4 filtered under reduced pressure. The filtered organic layer was evaporated under reduced pressure to a back by column chromatography the desired compound 5- (5-chloro-2-nitrophenyl) -1-phenyl-1H-indole (18g, Yield: 72%) was obtained.
72%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate In tetrahydrofuran; water at 80℃; for 12h;	2.2 Step 2 Synthesis of 5- (5-chloro-2-nitrophenyl) -1-phenyl-1H-indole 20 g, 73.49 mmol), 5-chloro-2-nitrophenylboronic acid (17.78 g, 88.18 mmol), K2CO3 (30.47 g, 220.47 mmol) and THF / H2O (400 ml / 100 ml) was added and stirred. At 40 ° CPd (PPh3) 4 (2.54 g, 2.204 mmol) was added and the mixture was refluxed and stirred at 80 for 12 hours. After completion of the reaction, the reaction mixture was extracted with dichloromethane. The organic layer was dried over MgSO4 and filtered under reduced pressure. The filtrated organic layer was distilled under reduced pressure, and then the target compound, 5- (5-chloro-2-nitrophenyl) -1-phenyl-1H-indole (18 g, yield: 72%) was obtained by column chromatography

Reference： [1]Current Patent Assignee: DOOSAN CORP. - KR2015/38811, 2015, A Location in patent: Paragraph 0165-0167
[2]Current Patent Assignee: DOOSAN CORP. - KR2015/8658, 2015, A Location in patent: Paragraph 0113-0115
[3]Current Patent Assignee: DOOSAN CORP. - KR101599586, 2016, B1 Location in patent: Paragraph 0135-0137

9
[ 532924-25-7 ]
7-chloro-3-phenyl-3,10-dihydropyrrolo[3,2-a]carbazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 12 h / 40 - 80 °C / Inert atmosphere 2: triphenylphosphine / 1,2-dichloro-benzene / 12 h / Inert atmosphere
	Multi-step reaction with 2 steps 1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 12 h / 40 - 80 °C / Inert atmosphere 2: triphenylphosphine / 1,2-dichloro-benzene / 12 h / Inert atmosphere

Reference： [1]Current Patent Assignee: DOOSAN CORP. - KR2015/38811, 2015, A
[2]Current Patent Assignee: DOOSAN CORP. - KR2015/8658, 2015, A

10
[ 532924-25-7 ]
3-phenyl-7-(9-phenyl-9H-carbazol-3-yl)-3,10-dihydropyrrolo[3,2-a]carbazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 12 h / 40 - 80 °C / Inert atmosphere 2: triphenylphosphine / 1,2-dichloro-benzene / 12 h / Inert atmosphere 3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide / tetrahydrofuran; water / 12 h / 40 - 80 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: DOOSAN CORP. - KR2015/38811, 2015, A

11
[ 532924-25-7 ]
C₃₅H₂₆N₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 12 h / 40 - 80 °C / Inert atmosphere 2: triphenylphosphine / 1,2-dichloro-benzene / 12 h / Inert atmosphere 3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide / tetrahydrofuran; water / 12 h / 40 - 80 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: DOOSAN CORP. - KR2015/38811, 2015, A

12
[ 532924-25-7 ]
C₂₀H₁₂BrN [ No CAS ]
C₂₆H₁₅ClN₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate In ethanol; water; toluene at 110℃; for 3h; Inert atmosphere;	4.3 <Step 3> Synthesis of D1 Under a nitrogen stream A2, 3.7g, (10.8 mmol), 5-chloro-2-nitrophenylboronic acid, 2.2g (10.8 mmol), 0.6g (5 mol%) of Pd (PPh3) 4, and potassium carbonate, 4.5g ( put Toluene / H2O / Ethanol of 32.3 mmol) and 80ml / 40ml / 40ml was stirred for 3 hours at 110 °C. After the reaction, using a methylene chloride The organic layer was separated using MgSO4 was removed [0182] water. The solvent of the organic layer was purified by column chromatography to give the title compound, D1, (3.7g, 8,7mmol, yield 81%).

Reference： [1]Current Patent Assignee: DOOSAN CORP. - KR2016/76355, 2016, A Location in patent: Paragraph 0166; 0179-0182

13
[ 532924-25-7 ]
7-chloro-3,10-diphenyl-3,10-dihydropyrrolo[3,2-a]carbazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 12 h / 40 - 80 °C / Inert atmosphere 2: triphenylphosphine / 1,2-dichloro-benzene / 12 h / Inert atmosphere 3: copper; potassium carbonate / nitrobenzene / 24 h / Inert atmosphere; Reflux

Reference： [1]Current Patent Assignee: DOOSAN CORP. - KR2015/8658, 2015, A

14
[ 532924-25-7 ]
7-(9H-carbazol-3-yl)-3,10-diphenyl-3,10-dihydropyrrolo[3,2-a]carbazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 12 h / 40 - 80 °C / Inert atmosphere 2: triphenylphosphine / 1,2-dichloro-benzene / 12 h / Inert atmosphere 3: copper; potassium carbonate / nitrobenzene / 24 h / Inert atmosphere; Reflux 4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 12 h / 40 - 80 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: DOOSAN CORP. - KR2015/8658, 2015, A

15
[ 532924-25-7 ]
3,10-diphenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,10-dihydropyrrolo[3,2-a]carbazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 12 h / 40 - 80 °C / Inert atmosphere 2: triphenylphosphine / 1,2-dichloro-benzene / 12 h / Inert atmosphere 3: copper; potassium carbonate / nitrobenzene / 24 h / Inert atmosphere; Reflux 4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / Inert atmosphere; Reflux

Reference： [1]Current Patent Assignee: DOOSAN CORP. - KR2015/8658, 2015, A

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P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere