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CAS No. : | 53299-66-4 | MDL No. : | MFCD18207271 |
Formula : | C10H10OS | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 178.25 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | To a cooled (-78C) solution of <strong>[20532-30-3]5-methoxybenzothiophene</strong> (1.00 g, 6.09 mmol) in tetrahydrofuran (24.4 mL) was added n-butyllithium (1 M in hexanes, 7.31 mL, 7.31 mmol). The reaction mixture was stirred at -78C for 2 h then iodomethane (2.59 g, 0.864 mL, 18.3 mmol) was added. The mixture was quenched with water and extracted with ethyl acetate (2x). The combined organic layer was concentrated under reduced pressure and the residue was purified by flash chromatography on silica gel eluting with ethyl acetate/heptane (0- 100%)). The appropriate fractions were combined and concentrated under reduced pressure to give 5-methoxy-2-methylbenzo[b]thiophene (0.87 g, 80%>) as a solid. |