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With boron tri(hydrogen sulphate); ammonium acetate In neat (no solvent) at 100℃; for 2h;
Synthesis of substituted pyrimidines 8a-m; general procedure
General procedure: A mixture of ketone (1 mmol), 0.44 g triethyl orthoformate (3 mmol),0.14 g NH4OAc (2 mmol) and 0.06 g BSA (20 mol%) was heated at100 °C for 2 h. After completion of the reaction as indicated by TLC,the reaction mixture was cooled, quenched by adding 10 cm3 water,extracted with chloroform (3 × 20 cm3), and the extract was dried with Na2SO4. The filtrate was evaporated under vacuum, and the crudeproduct was recrystallised from ethyl acetate/n-hexane to afford thepure products.
70%
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide; ammonium acetate In neat (no solvent) at 100 - 110℃; for 0.116667h; Green chemistry;
2.1. General procedure for synthesis of pyrimidine
General procedure: A mixture of triethoxymethane (3 mmol), ammonium acetate (2 mmol), ketone (1 mmol), and TBBDA (0.1 g,18 mol %) was heated at 100-110° C for the appropriate time. After completion of the reaction (TLC acetone/nhexane[2:10]), the mixture was cooled, and cold CH2Cl2(15 mL) was added, then the catalyst was removed by filtration. The organic phase was washed with water(3 *10 mL), dried and concentrated. The product was purified by TLC (TLC acetone/n-hexane [2:10]).
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