Dehydrobenzperidol;DHBP;Taylor Brand of Droperidol;Kern Brand of Droperidol;Janssen Brand of Droperidol;Properidol;Dridol;Inapsine;Droleptan;NSC 169874
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Hydrolyse m. wss.HCl Bildung 4'-Fluor-4-(4-oxopiperidino)-butyrophenon u. 2-Benzimidazolinon;
Yield
Reaction Conditions
Operation in experiment
The following specific crystallizable substances can be mentioned by way of example. 1. General anesthetics: Ketamine hydrochloride, thiamylal sodium, thiopental sodium, droperidol.
22 EXAMPLE 22
EXAMPLE 22 To a stirred solution of 2.0 g of 1-(p-fluoro-phenyl)-4-[4-(2-oxo-1-benzimidazolinyl)-1,2,3,6-tetrahydro-1-pyridyl]-1-butanol in 60 ml of chloroform at room temperature, was added portionwise 3.2 g of a fine powder of manganese dioxide. After completion of addition, the mixture was stirred for another 2 hours at room temperature, and the precipitate was filtered off. The filtrate was concentrated to dryness under reduced pressure, and the residue was recrystallized from dioxane containing water, to obtain γ-[4-(2-oxo-1-benzimidazolinyl)-1,2,3,6-tetrahydro-1-pyridyl]-p-fluorobutyrophenone, melting at 146° - 147 5°C.