Home Cart 0 Sign in  

[ CAS No. 548769-96-6 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 548769-96-6
Chemical Structure| 548769-96-6
Structure of 548769-96-6 * Storage: {[proInfo.prStorage]}

Quality Control of [ 548769-96-6 ]

Related Doc. of [ 548769-96-6 ]

SDS
Alternatived Products of [ 548769-96-6 ]
Alternatived Products of [ 548769-96-6 ]

Product Details of [ 548769-96-6 ]

CAS No. :548769-96-6 MDL No. :MFCD06659845
Formula : C13H14BNO4S Boiling Point : 520.535°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :291.13 g/mol Pubchem ID :-
Synonyms :

Safety of [ 548769-96-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 548769-96-6 ]

  • Downstream synthetic route of [ 548769-96-6 ]

[ 548769-96-6 ] Synthesis Path-Downstream   1~5

  • 1
  • C18H23BN2O4S [ No CAS ]
  • [ 548769-96-6 ]
YieldReaction ConditionsOperation in experiment
Stage #1: C18H23BN2O4S In dichloromethane at 20℃; for 1h; Stage #2: With sodium hydroxide In water Stage #3: With hydrogenchloride In water 6 Example 6; 4-Benzylsulfamoylbenzeneboronic acid Lithium 4-sulfinyl-phenylboronic acid N-methyl-diethanolamine ester (275 mg, 1.0 mmol) was suspended in CH2Cl2 (2 mL). N-Chlorosuccinimide (147 mg, 1.10 mmol) was added and the mixture was stirred at room temperature for 1 h. Benzylamine (0.23 mL, 2.1 mmol) was added and the reaction mixture was stirred for 1 h at room temperature. Then, Dowex 50WX2-400 cation exchange resin (about 1 g) was added and the mixture was stirred for further 1 h. The resin was removed by filtration and extracted with CH2Cl2:MeOH (9:1). To the combined organic filtrates was added 1N NaOH and the aqueous phase was washed with CH2Cl2. The aqueous phase was acidified with 1N HCl and the resulting crystals were isolated by filtration to give 163 mg (56%) of the title compound: 1H NMR (DMSO-d6+DCl): δ7.95 (d, 2H), 7.78 (d, 2H), 7.32-7.19 (m, 5H), 3.97 (s, 2H).
  • 2
  • [ 548769-96-6 ]
  • [ 548769-90-0 ]
  • [ 548769-95-5 ]
YieldReaction ConditionsOperation in experiment
Methyl-phenyl-carbamic Acid 4'-benzylsulfamoyl-biphenyl-4-yl Ester Methyl-phenyl-carbamic Acid 4'-benzylsulfamoyl-biphenyl-4-yl Ester The title compound was prepared from methyl-phenyl-carbamic acid 4-iodo-phenyl ester and 4-benzylsulfamoylbenzeneboronic acid. The crude product was purified by preparative HPLC (Gilson) (35%, pink crystals). HPLC-MS: m/z=473.0 (M+1); Rt=4.80 min.
  • 3
  • [ 100-46-9 ]
  • lithium 4-sulfinyl N-methyl-diethanolamine phenylboronate [ No CAS ]
  • [ 548769-96-6 ]
YieldReaction ConditionsOperation in experiment
56% Stage #1: lithium 4-sulfinyl N-methyl-diethanolamine phenylboronate With N-chloro-succinimide In dichloromethane at 20℃; for 1h; Stage #2: benzylamine at 20℃; for 1h; Stage #3: With hydrogenchloride; sodium hydroxide more than 3 stages; 6 Example 6; 4-BENZYLSULFAMOYLBENZENEBORONIC ACID Lithium 4-SULFINYL-PHENYLBORONIC acid N-methyl-diethanolamine ester (275 mg, 1.0 MMOL) was suspended in CH2CI2 (2 mL). N-CHLOROSUCCINIMIDE (147 mg, 1.10 MMOL) was added and the mixture was stirred at room temperature for 1 h. Benzylamine (0.23 mL, 2.1 MMOL) was added and the reaction mixture was stirred for 1 h at room tempera- ture. Then, Dowex 50WX2-400 cation exchange resin (about 1 g) was added and the mixture was stirred for further 1 h. The resin was removed by filtration and extracted with CH2CI2 : MeOH (9: 1). To the combined organic filtrates was added 1 N NAOH and the aqueous phase was washed with CH2CI2. The aqueous phase was acidified with 1 N HCI and the resulting crystals were isolated by filtration to give 163 mg (56%) of the title compound :'H NMR (DMSO-D6+DCI) : 67. 95 (d, 2H), 7.78 (d, 2H), 7.32-7. 19 (m, 5H), 3.97 (s, 2H).
  • 4
  • [ 548769-96-6 ]
  • [ 1451092-95-7 ]
  • [ 1451094-16-8 ]
YieldReaction ConditionsOperation in experiment
37% With palladium diacetate; sodium carbonate; triphenylphosphine In 1,2-dimethoxyethane; water for 2h; Inert atmosphere; Reflux; 38 [4-(4-Benzylsulfamoyl-phenyl)-6-chloro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester A stirred solution of (6-chloro-3-methyl-4-trifluoromethanesulfonyloxy-naphthalen-2-yl)-acetic acid methyl ester (0.20 g, 0.50 mmol) in dimethoxyethane (10 mL) was purged with argon for 5 minutes at room temperature. Triphenylphosphine (0.030 g, 0.11 mmol), palladium (II) acetate (0.013 g, 0.055 mmol), 4-N-benzylsulfamoylphenylboronic acid (0.198 g, 0.68 mmol) and a 2 M aqueous solution of sodium carbonate (1.0 mL, 2.0 mmol) were added simultaneously to the reaction mixture at room temperature under argon. The reaction mixture was refluxed for 2 hours and then cooled to room temperature. Water was added and the mixture was extracted twice with ethyl acetate. The collected organic extracts were washed with water and then brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product, which was finally purified using flash chromatography (Biotage, 5-10% ethyl acetate-hexane) to afford [4-(4-benzylsulfamoyl-phenyl)-6-chloro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (0.093 g, 37%) as a solid. MS calcd. for C27H23ClNO4S [(M-H)-] 492, obsd. 492.3.
  • 5
  • [ 548769-96-6 ]
  • [ 1227259-08-6 ]
  • [ 1451094-42-0 ]
YieldReaction ConditionsOperation in experiment
46% With palladium diacetate; sodium carbonate; triphenylphosphine In 1,2-dimethoxyethane; water for 2h; Inert atmosphere; Reflux; 51 [4-(4-Benzylsulfamoyl-phenyl)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester A stirred solution of (6-fluoro-3-methyl-4-trifluoromethanesulfonyloxy-naphthalen-2-yl)-acetic acid methyl ester (0.20 g, 0.52 mmol) in dimethoxyethane (10 mL) for 5 minutes at room temperature. Triphenylphosphine (0.031 g, 0.12 mmol), palladium (II) acetate (0.013 g, 0.06 mmol), 4-N-benzylsulfamoylphenylboronic acid (0.206 g, 0.71 mmol) and a 2 M aqueous solution of sodium carbonate (1.0 mL, 2.0 mmol) were added simultaneously to the reaction mixture at room temperature under argon. The reaction mixture was refluxed for 2 hours and then cooled to room temperature. Water was added and the mixture was extracted twice with ethyl acetate. The collected organic extracts were washed with water and then brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product, which was finally purified using flash chromatography (Biotage, 5-10% ethyl acetate-hexane) to afford [4-(4-benzylsulfamoyl-phenyl)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (0.110 g, 46%) as a solid. MS calcd. for C27H23FNO4S [(M-H)-] 476, obsd. 476.3.
Historical Records

Similar Product of
[ 548769-96-6 ]

Chemical Structure| 1574389-50-6

A1600405[ 1574389-50-6 ]

N-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide

Reason: Different form