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[ CAS No. 54920-77-3 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 54920-77-3
Chemical Structure| 54920-77-3
Structure of 54920-77-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 54920-77-3 ]

CAS No. :54920-77-3 MDL No. :MFCD18971591
Formula : C8H4Br2N2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :287.94 Pubchem ID :-
Synonyms :

Safety of [ 54920-77-3 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 54920-77-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54920-77-3 ]

[ 54920-77-3 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 54920-76-2 ]
  • [ 54920-77-3 ]
YieldReaction ConditionsOperation in experiment
suspension of 2.59 g (16.0 mmol) [1 ,7]naphthyridine-2,4-diol in 32 ml 1-butyl-1- methyl-pyrrolidinium trifluoromethylsulfonate was treated with 15.1 g (52.8 mmol) phosphorus oxybromide. The reaction mixture was stirred for 18 h at 85 C. The reaction mixture was cooled to room temperature. Ice and 12 ml 50% aqueous NaOH were added. The resulting precipitate was filtered off, washed with water and dried under vacuum yielding 2,4-dibromo-[1 ,7]naphthyridine as light brown crystals; HPLC/MS (A): 2.18 min, [M+H] = 289.1H NMR (400 MHz, CDCI3) delta = 9.37 (s, 1 H), 8.70 (d, J=5.8, 1 H), 7.97 (s, 1 H), 7.86 (d, J=5.8, 1 H)
With phosphorus(V) oxybromide; (1-butyl-1-methylpyrrolidinium)trifluoromethanesulfonate; at 85℃; for 18.0h; 2. A suspension of 2.59 g (16.0 mmol) <strong>[54920-76-2][1,7]naphthyridine-2,4-diol</strong> in 32 ml 1-butyl-1-methyl-pyrrolidinium trifluoromethylsulfonate was treated with 15.1 g (52.8 mmol) phosphorus oxybromide. The reaction mixture was stirred for 18 h at 85 C. The reaction mixture was cooled to room temperature. Ice and 12 ml 50% aqueous NaOH were added. The resulting precipitate was filtered off, washed with water and dried under vacuum yielding 2,4-dibromo-[1,7]naphthyridine as light brown crystals; HPLC/MS (A): 2.18 min, [M+H]=289. 1H NMR (400 MHz, CDCl3) delta=9.37 (s, 1H), 8.70 (d, J=5.8, 1H), 7.97 (s, 1H), 7.86 (d, J=5.8, 1H).
With phosphorus(V) oxybromide; at 85℃; Intermediate 10A-1 Step 2: 2,4-d hyridine To 500 mg (3.08 mmol) of intermediate 10A-1 step 1 and 6.5 mL 1- methylpyrrolidinium trifluoromethanesulfonate, 2.92 g (10.2 mmol) phosphorous(V) oxybromide was added. The slurry was stirred overnight at 85C. After cooling to room temperature, 50% aqueous sodium hydroxide and crushed ice were added. The precipitate was filtered off and dried to yield 260 mg (95% purity, 28% yield) of the desired title compound. 1H NMR (300 MHz, DMSO-d6): delta [ppm] = 7.99 (d, 1H), 8.50 (s, 1H), 8.81 (d, 1H), 9.38 (s, 1H).
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