Alternatived Products of [ 5493-71-0 ]
Alternatived Products of [ 5493-71-0 ]
Product Details of [ 5493-71-0 ]
CAS No. : | 5493-71-0 | MDL No. : | MFCD15143590 |
Formula : |
C8H8ClNO3
|
Boiling Point : |
- |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 201.61 | Pubchem ID : | - |
Synonyms : |
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Computed Properties of [ 5493-71-0 ]
TPSA :Topological Polar Surface Area |
- |
H-Bond Acceptor Count : |
- |
XLogP3 : |
- |
H-Bond Donor Count : |
- |
SP3 : |
- |
Rotatable Bond Count : |
- |
Safety of [ 5493-71-0 ]
Signal Word: | | Class: | |
Precautionary Statements: | | UN#: | |
Hazard Statements: | | Packing Group: | |
Application In Synthesis of [ 5493-71-0 ]
- Upstream synthesis route of [ 5493-71-0 ]
- Downstream synthetic route of [ 5493-71-0 ]
- 1
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[ 5493-71-0 ]

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[ 5211-02-9 ]
Yield | Reaction Conditions | Operation in experiment |
61.6% |
With iron; ammonium chloride; In ethanol; at 80℃; for 3.0h; |
Dissolve ammonium chloride (2.7 g, 50.4 mmol) in water (10 mL), add it to a turbid solution of iron powder (942 mg, 16.8 mmol) in ethanol (30 mL), heat to 80 C and stir, add 2- (2- A solution of chloro-4-nitrophenoxy) ethyl-1-yl (1.22 g, 5.6 mmol) in ethanol (10 mL), reacted at reflux for 1 h, cooled to room temperature, filtered through celite, the filtrate was concentrated, and EA (20 mL) was added ) The residue was dissolved, washed with saturated brine (20 mL × 3), washed with water (20 mL × 2), dried over anhydrous magnesium sulfate, and column chromatography (P / E = 3: 1 1: 1) to obtain 647 mg of an off-white solid. The rate is 61.6%, melting point: 64-65 C. |