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CAS No. : | 56100-20-0 | MDL No. : | MFCD08062569 |
Formula : | C11H10N2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LECLRDWVJRSFSE-UHFFFAOYSA-N |
M.W : | 170.21 | Pubchem ID : | 11073848 |
Synonyms : |
|
Num. heavy atoms : | 13 |
Num. arom. heavy atoms : | 12 |
Fraction Csp3 : | 0.09 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 52.43 |
TPSA : | 25.78 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.02 cm/s |
Log Po/w (iLOGP) : | 2.2 |
Log Po/w (XLOGP3) : | 1.86 |
Log Po/w (WLOGP) : | 2.45 |
Log Po/w (MLOGP) : | 1.2 |
Log Po/w (SILICOS-IT) : | 2.98 |
Consensus Log Po/w : | 2.14 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.68 |
Solubility : | 0.352 mg/ml ; 0.00207 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.02 |
Solubility : | 1.62 mg/ml ; 0.00949 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -4.55 |
Solubility : | 0.0048 mg/ml ; 0.0000282 mol/l |
Class : | Moderately soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.86 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With bromine; In water; benzene; for 0.5h;Reflux; | Diethyl 2-(2,2-bipyridine-5-ylmethyl)-2-acetamidomalonate Methyl-2,2'-bipyridine (1.7 g, 10 mmol) in a mixed solvent (100 mL) of water and benzene (1:1) was irradiated and refluxed using a halogen lamp (150 W). Bromine (1.6 g, 10 mmol) was added and the mixture was heated to reflux for 30 min. The solution was concentrated under reduced ressure and dissolved in EtOAc. The organic layer was washed with saturated aqueous NaHCO3 solution, dried over MgSO4, and concentrated under reduced pressure to afford the crude brominated product. A mixture of diethyl acetamidomalonate (2.6 g, 12 mmol) and sodium hydride (0.48 g, 12 mmol, 60% in mineral oil) in dry DMF (50 mL) was stirred for 30 min at 0 C. To the solution was added the crude product in dry DMF (20 mL) at 0 C. and the mixture was stirred for 1 h at room temperature. The reaction mixture was diluted with EtOAc (200 mL) and washed with a 10% aqueous sodium thiosulfate solution (2*150 mL). The organic layer was dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by flash column chromatography (0.5% MeOH in CH2Cl2) to give diethyl 2-(2,2'-bipyridine-5-ylmethyl)-2-acetamidomalonate (2.5 g, 65%) as a white solid. 1H-NMR (500 MHz, CDCl3): 1.38 (m, 6H), 2.15 (s, 3H), 3.81 (s, 2H), 4.35 (m, 4H), 6.68 (s, 1H), 7.36 (dd, 1H), 7.55 (dd, 1H), 7.87 (m, 1H), 8.36 (d, 1H), 8.41 (d, 1H), 8.42 (d, 1H), 8.74 (dd, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With potassium fluoride; copper(l) iodide; palladium diacetate; catacxium A; In N,N-dimethyl-formamide; at 90℃; for 12h;Inert atmosphere; | General procedure: 2-Trimethylsilylpyridine (1.2mmol), the aryl halide (1mmol), palladium acetate (0.10mmol), CataXCium A (0.2mmol), CuI (76mg, 0.4mmol) and KF (2.20mmol) were combined in reaction tubes in a Radleys green-house parallel synthesiser under a flow of nitrogen and degassed DMF (1ml) was added. The resulting suspensions were stirred at 90 oC under nitrogen for 12 hours. Reactions were analysed by LC-MS at 1mg/1ml in methanol to determine the yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | With potassium fluoride; copper(l) iodide; palladium diacetate; catacxium A; In N,N-dimethyl-formamide; at 90℃; for 12h;Inert atmosphere; | 2-Trimethylsilylpyridine (712 mg, 4.7 mmol) (1), 2-bromo-5-methylpyridine (674 mg, 3.92 mmol) (5), palladium acetate (45 mg, 0.196 mmol, 5 mol%), CataXCium A (141 mg, 0.392 mmol), CuI (299mg, 1.57 mmol) and KF (501 mg, 8.62 mmol) were combined in a reaction tube in a Radleys green-house parallel synthesiser under a flow of nitrogen and degassed DMF (3 ml) was added. The resulting suspension was stirred at 90 oC under nitrogen for 12 hours. The reaction mixture was partitioned between DCM (10ml) and 0.880 ammonia (10ml). The aqueous was extracted with DCM (2 x 10ml). The combined organics were dried and evaporated to obtain a dark brown oil. The crude was purified by flash chromatography (1:0 - 3:7 heptane - ethyl acetate) to provide 418mg (63% yield) of the product as a yellow solid. The spectroscopic data of known 2-pyridyl-5-methyl pyridine was in good agreement with the literature data. J. Org. Chem., 2010, 75 (2), pp 424-433 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56% | General procedure: To a mixture of dry diisopropylamine (1.70 mL, 12.0 mmol, 2.40 equiv) and dry THF (12 mL) was10 added dropwise n-butyllithium (1.63 M n-hexane solution, 6.13 mL, 10.0 mmol, 2.00 equiv) at -78 oC under a nitrogen atmosphere. The solution was stirred for 30 min at 0 oC and 5-methyl-2,2-bipyridine(9) (855 mg, 5.02 mmol, 1.00 equiv) in dry THF (50 mL) was added at -78 oC. The temperature wasallowed to raise gradually over 4 h to -40 oC. The solution was recooled to -78oC and 1,10-dibromodecane (7.50 g, 25.0 mmol, 5.00 equiv) in dry THF (25 mL) was added. The solution was allowed to warm up to room temperature and stirred overnight. After the addition of water, THF wasevaporated under reduced pressure. Sodium hydrogen carbonate solution was added and the mixturewas extracted with dichloromethane. The extract was washed with brine and dried over sodium sulfate.After filtration, the solvent was removed under reduced pressure. The crude product was purified bycolumn chromatography on basic aluminum oxide (toluene) to give 10a as a white powder (1.10 g,20 56%). Analytically pure sample was obtained by recrystallization from hexane. | |
52% | To a solution of dry diisopropylamine ( 1.70 mL, 12.0 mmol) in dry THF (12.0 mL) was added dropwise n-butyllithium (1.63 M n-hexane solution, 6.13 mL , 10.0 mmol) at -78 C under an argon atmosphere. The solution was stirred for 30 min at 0 C and <strong>[56100-20-0]5-methyl-2,2'-bipyridine</strong> ( 2)1 (0.851 g, 5.00 mmol) in dry THF (50 mL) was added at -78 C. After stirring at -40 C for 3 h, 1,10-dibromodecane (7.50 g, 25.0 mmol) in dry THF (25 mL) was added. The solution was a llowed to warm up to room temperature and stirred overnight. The reaction mixture was quenched with water and the solvent was evaporated under reduced pressure. After the addition of a saturated aqueous solution of sodium hydrogen carbonate, the mixture was extracted with dichloromethane. The organic solution was dried over magnesium sulfate and filtered. Following the removal of the solvent, the brown residue was purified by a column chromatography on basic aluminum oxide (hexane-ethyl acetate = 19:1) to give 3 as a white powder (1.02 g, 52%) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
7%Chromat.; 34%Chromat.; 38%Chromat.; 7%Chromat.; 14%Chromat. | With nickel(II) bromide hydrate; sodium iodide; In N,N-dimethyl-formamide; at 20℃;Electrochemical reaction; Inert atmosphere; | General procedure: The controlled current preparative electrolysis were carried out with a potentiostat/galvanostat equipment. Undivided cells with 20 mL compartment were used. Zn or Fe metallic rod with 8 mm diameter was used as the sacrificial anode. Ni foam (6 cm×3.5 cm) was used as the cathode. It could be re-used after washing with a 6 M HCl solution following by water and acetone, and dried. The same solution was used to clean the anode. A 5 mL DMF solution containing 7% or 20% of NiBr2·xH2O or [Ni(bpy)]Br221 and x mmol of the corresponding mixture of 2-bromomethylpyridines or 2,6-dihalopyridines (heterocouplings in Table 1, Table 2, Table 4 and Table 5), or (2.5 mmol) of 2,6-dihalopyridines (homocoupling in Table 3) was stirred or sonicated before the electrolysis, to ensure the solubilization of reagents. A pre-electrolysis was carried out with 15 mL of the electrolytic solution (DMF, 0.1 M NaI and 0.75 mmol of 1,2-dibromoethane), passing a charge of 146 C (I=150 mA). Then, the previous prepared solution of bromopicoline or bromopyridine and the catalyst in 5 mL DMF, was added to the electrolytic cell and the constant current electrolysis (I=100 mA) applied. It is important to ensure that the cell potential must not exceed 1.8 V in order to avoid the reduction of the substrate on the cathode surface. After the total consumption of the reagent (number of coulombs described in the tables), the reaction was stopped and the solvent removed under reduced pressure. The residue was dissolved in CH2Cl2 and washed with several portions of a 6 M NH4OH solution. After drying over Na2SO4, the organic layer was evaporated under reduced pressure. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
34%Chromat.; 44%Chromat.; 16%Chromat. | With nickel(II) bromide hydrate; sodium iodide; In N,N-dimethyl-formamide; at 20℃;Electrochemical reaction; Inert atmosphere; | General procedure: The controlled current preparative electrolysis were carried out with a potentiostat/galvanostat equipment. Undivided cells with 20 mL compartment were used. Zn or Fe metallic rod with 8 mm diameter was used as the sacrificial anode. Ni foam (6 cm×3.5 cm) was used as the cathode. It could be re-used after washing with a 6 M HCl solution following by water and acetone, and dried. The same solution was used to clean the anode. A 5 mL DMF solution containing 7% or 20% of NiBr2·xH2O or [Ni(bpy)]Br221 and x mmol of the corresponding mixture of 2-bromomethylpyridines or 2,6-dihalopyridines (heterocouplings in Table 1, Table 2, Table 4 and Table 5), or (2.5 mmol) of 2,6-dihalopyridines (homocoupling in Table 3) was stirred or sonicated before the electrolysis, to ensure the solubilization of reagents. A pre-electrolysis was carried out with 15 mL of the electrolytic solution (DMF, 0.1 M NaI and 0.75 mmol of 1,2-dibromoethane), passing a charge of 146 C (I=150 mA). Then, the previous prepared solution of bromopicoline or bromopyridine and the catalyst in 5 mL DMF, was added to the electrolytic cell and the constant current electrolysis (I=100 mA) applied. It is important to ensure that the cell potential must not exceed 1.8 V in order to avoid the reduction of the substrate on the cathode surface. After the total consumption of the reagent (number of coulombs described in the tables), the reaction was stopped and the solvent removed under reduced pressure. The residue was dissolved in CH2Cl2 and washed with several portions of a 6 M NH4OH solution. After drying over Na2SO4, the organic layer was evaporated under reduced pressure. |
43%Chromat.; 33%Chromat.; 18%Chromat. | With nickel(II) bromide hydrate; sodium iodide; In N,N-dimethyl-formamide; at 20℃;Electrochemical reaction; Inert atmosphere; | General procedure: The controlled current preparative electrolysis were carried out with a potentiostat/galvanostat equipment. Undivided cells with 20 mL compartment were used. Zn or Fe metallic rod with 8 mm diameter was used as the sacrificial anode. Ni foam (6 cm×3.5 cm) was used as the cathode. It could be re-used after washing with a 6 M HCl solution following by water and acetone, and dried. The same solution was used to clean the anode. A 5 mL DMF solution containing 7% or 20% of NiBr2·xH2O or [Ni(bpy)]Br221 and x mmol of the corresponding mixture of 2-bromomethylpyridines or 2,6-dihalopyridines (heterocouplings in Table 1, Table 2, Table 4 and Table 5), or (2.5 mmol) of 2,6-dihalopyridines (homocoupling in Table 3) was stirred or sonicated before the electrolysis, to ensure the solubilization of reagents. A pre-electrolysis was carried out with 15 mL of the electrolytic solution (DMF, 0.1 M NaI and 0.75 mmol of 1,2-dibromoethane), passing a charge of 146 C (I=150 mA). Then, the previous prepared solution of bromopicoline or bromopyridine and the catalyst in 5 mL DMF, was added to the electrolytic cell and the constant current electrolysis (I=100 mA) applied. It is important to ensure that the cell potential must not exceed 1.8 V in order to avoid the reduction of the substrate on the cathode surface. After the total consumption of the reagent (number of coulombs described in the tables), the reaction was stopped and the solvent removed under reduced pressure. The residue was dissolved in CH2Cl2 and washed with several portions of a 6 M NH4OH solution. After drying over Na2SO4, the organic layer was evaporated under reduced pressure. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
7%Chromat.; 18%Chromat.; 28%Chromat.; 10%Chromat.; 37%Chromat. | With nickel(II) bromide hydrate; sodium iodide; In N,N-dimethyl-formamide; at 20℃;Electrochemical reaction; Inert atmosphere; | General procedure: The controlled current preparative electrolysis were carried out with a potentiostat/galvanostat equipment. Undivided cells with 20 mL compartment were used. Zn or Fe metallic rod with 8 mm diameter was used as the sacrificial anode. Ni foam (6 cm×3.5 cm) was used as the cathode. It could be re-used after washing with a 6 M HCl solution following by water and acetone, and dried. The same solution was used to clean the anode. A 5 mL DMF solution containing 7% or 20% of NiBr2·xH2O or [Ni(bpy)]Br221 and x mmol of the corresponding mixture of 2-bromomethylpyridines or 2,6-dihalopyridines (heterocouplings in Table 1, Table 2, Table 4 and Table 5), or (2.5 mmol) of 2,6-dihalopyridines (homocoupling in Table 3) was stirred or sonicated before the electrolysis, to ensure the solubilization of reagents. A pre-electrolysis was carried out with 15 mL of the electrolytic solution (DMF, 0.1 M NaI and 0.75 mmol of 1,2-dibromoethane), passing a charge of 146 C (I=150 mA). Then, the previous prepared solution of bromopicoline or bromopyridine and the catalyst in 5 mL DMF, was added to the electrolytic cell and the constant current electrolysis (I=100 mA) applied. It is important to ensure that the cell potential must not exceed 1.8 V in order to avoid the reduction of the substrate on the cathode surface. After the total consumption of the reagent (number of coulombs described in the tables), the reaction was stopped and the solvent removed under reduced pressure. The residue was dissolved in CH2Cl2 and washed with several portions of a 6 M NH4OH solution. After drying over Na2SO4, the organic layer was evaporated under reduced pressure. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
30%Chromat.; 34%Chromat.; 30%Chromat. | With nickel(II) bromide hydrate; sodium iodide; In N,N-dimethyl-formamide; at 20℃;Electrochemical reaction; Inert atmosphere; | General procedure: The controlled current preparative electrolysis were carried out with a potentiostat/galvanostat equipment. Undivided cells with 20 mL compartment were used. Zn or Fe metallic rod with 8 mm diameter was used as the sacrificial anode. Ni foam (6 cm×3.5 cm) was used as the cathode. It could be re-used after washing with a 6 M HCl solution following by water and acetone, and dried. The same solution was used to clean the anode. A 5 mL DMF solution containing 7% or 20% of NiBr2·xH2O or [Ni(bpy)]Br221 and x mmol of the corresponding mixture of 2-bromomethylpyridines or 2,6-dihalopyridines (heterocouplings in Table 1, Table 2, Table 4 and Table 5), or (2.5 mmol) of 2,6-dihalopyridines (homocoupling in Table 3) was stirred or sonicated before the electrolysis, to ensure the solubilization of reagents. A pre-electrolysis was carried out with 15 mL of the electrolytic solution (DMF, 0.1 M NaI and 0.75 mmol of 1,2-dibromoethane), passing a charge of 146 C (I=150 mA). Then, the previous prepared solution of bromopicoline or bromopyridine and the catalyst in 5 mL DMF, was added to the electrolytic cell and the constant current electrolysis (I=100 mA) applied. It is important to ensure that the cell potential must not exceed 1.8 V in order to avoid the reduction of the substrate on the cathode surface. After the total consumption of the reagent (number of coulombs described in the tables), the reaction was stopped and the solvent removed under reduced pressure. The residue was dissolved in CH2Cl2 and washed with several portions of a 6 M NH4OH solution. After drying over Na2SO4, the organic layer was evaporated under reduced pressure. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | 5-Methyl-2,2'-bipyridine (0.600 g, 3.5 mmol) was dissolved in THF (20 mL degassed under N2) in a 250 mL round-bottomed flask. 1.8 M LDA (4 mL, 7 mmol) was used to added dropwise using a cannula at -78 C. After stirring at -78 C for 2 h under N2, 5-(bromomethyl)-2,2'-bipyridine (868 mg, 3.5 mmol) dissolved in a degassed THF solution (20 mL) was added dropwise. After warming to room temperature and stirring for 24 h, the mixture was quenched with a saturated aqueous NaCl (20 mL) solution. The organic solvent was mostly evaporated and the remaining was extracted with CH2Cl2. The organic layer was dried over MgSO4 and concentrated by rotary evaporator to give a crude product. The coupling product was purified by flash column chromatography (silica gel, MeOH/CH2Cl2 = 1/9). Yield: 67% (792 mg), TLC (SiO2): Rf 0.57 (10% methanol/dichloromethane); IR (KBr, cm-1) 3051 (Ar-H), 3006 (Ar-H), 2916 (C-H), 2856 (C-H), 1458 (aromatic C=C), 1H NMR (400 MHz, CDCl3) delta 3.04 (d, J = 4.0 Hz, 4H, CH2), 7.27-7.31 (m, 2H, PyH), 7.58-7.61 (m, 2H, PyH), 7.78-7.82 (m, 2H, PyH), 8.29-8.36 (m, 4H, PyH), 8.48-8.49 (m, 2H, PyH), 8.65-8.67 (m, 2H, PyH); MS/EI m/z 338 [M+, 51%], 169 [M+-CH2bpy, 100%], 141 [M+-NCH2CH2bpy, 20%]. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | General procedure: To a mixture of dry diisopropylamine (1.70 mL, 12.0 mmol, 2.40 equiv) and dry THF (12 mL) was10 added dropwise n-butyllithium (1.63 M n-hexane solution, 6.13 mL, 10.0 mmol, 2.00 equiv) at -78 oC under a nitrogen atmosphere. The solution was stirred for 30 min at 0 oC and 5-methyl-2,2-bipyridine(9) (855 mg, 5.02 mmol, 1.00 equiv) in dry THF (50 mL) was added at -78 oC. The temperature wasallowed to raise gradually over 4 h to -40 oC. The solution was recooled to -78oC and 1,10-dibromodecane (7.50 g, 25.0 mmol, 5.00 equiv) in dry THF (25 mL) was added. The solution was allowed to warm up to room temperature and stirred overnight. After the addition of water, THF wasevaporated under reduced pressure. Sodium hydrogen carbonate solution was added and the mixturewas extracted with dichloromethane. The extract was washed with brine and dried over sodium sulfate.After filtration, the solvent was removed under reduced pressure. The crude product was purified bycolumn chromatography on basic aluminum oxide (toluene) to give 10a as a white powder (1.10 g,20 56%). Analytically pure sample was obtained by recrystallization from hexane. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | General procedure: To a mixture of dry diisopropylamine (1.70 mL, 12.0 mmol, 2.40 equiv) and dry THF (12 mL) was10 added dropwise n-butyllithium (1.63 M n-hexane solution, 6.13 mL, 10.0 mmol, 2.00 equiv) at -78 oC under a nitrogen atmosphere. The solution was stirred for 30 min at 0 oC and 5-methyl-2,2-bipyridine(9) (855 mg, 5.02 mmol, 1.00 equiv) in dry THF (50 mL) was added at -78 oC. The temperature wasallowed to raise gradually over 4 h to -40 oC. The solution was recooled to -78oC and 1,10-dibromodecane (7.50 g, 25.0 mmol, 5.00 equiv) in dry THF (25 mL) was added. The solution was allowed to warm up to room temperature and stirred overnight. After the addition of water, THF wasevaporated under reduced pressure. Sodium hydrogen carbonate solution was added and the mixturewas extracted with dichloromethane. The extract was washed with brine and dried over sodium sulfate.After filtration, the solvent was removed under reduced pressure. The crude product was purified bycolumn chromatography on basic aluminum oxide (toluene) to give 10a as a white powder (1.10 g,20 56%). Analytically pure sample was obtained by recrystallization from hexane. |
Tags: 56100-20-0 synthesis path| 56100-20-0 SDS| 56100-20-0 COA| 56100-20-0 purity| 56100-20-0 application| 56100-20-0 NMR| 56100-20-0 COA| 56100-20-0 structure
[ 74173-48-1 ]
4-Methyl-4'-vinyl-2,2'-bipyridine
Similarity: 0.93
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P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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